Výsledky vyhledávání - "Sabina N. Sheikh"

The Synthetic Retinoid AGN 193109 but Not Retinoic Acid Elevates CYP1A1 Levels in Mouse Embryos and Hepa-1c1c7 Cells

Autor: Kenneth J. Soprano, Roshantha A.S. Chandraratna, Jerome L. Gabriel, Sabina N. Sheikh, Carlo J. Gambone, Dianne Robert Soprano, D. M. Kochhar

Publikováno v: Toxicology and Applied Pharmacology. 174:153-159

The synthetic retinoid AGN 193109 is a potent pan retinoic acid receptor (RAR) antagonist. Treatment of pregnant mice with a single oral 1 mg/kg dose of this antagonist on day 8 postcoitum results in severe craniofacial (median cleft face or frontona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::548cc7755c91ccc82de591372b5a4075
https://doi.org/10.1006/taap.2001.9209

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Coxsackievirus B4 Alters Pancreatic Glutamate Decarboxylase Expression in Mice Soon After Infection

Autor: Nando K. Chatterjee, Sabina N. Sheikh, Jun Hou, David L. Martin

Publikováno v: Journal of Autoimmunity. 6:529-542

The 64,000-M r (64K) islet autoantigen, which is considered to be a target protein of beta cell destruction in insulin-dependent diabetes mellitus (IDDM), has recently been identified as the enzyme glutamic acid decarboxylase (GAD). We reported a two

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035fe375e8cd32f6e49102076dae51ec
https://doi.org/10.1006/jaut.1993.1044

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p53, but not p16 mutations in oral squamous cell carcinomas are associated with specific CYP1A1 and GSTM1 polymorphic genotypes and patient tobacco use

Autor: Jong Y. Park, Stimson P. Schantz, John P. Richie, Sabina N. Sheikh, Qing Ren, Jordan C. Stern, Philip Lazarus

Publikováno v: Carcinogenesis. 19(3)

Inactivation of tumor suppressor genes like p53 and p16 play a key role in tumor progression, with a high incidence of mutations existing for both genes in oral squamous cell carcinomas. Previous studies have demonstrated, (i) a correlation between t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e190f1fc76c25b2e9235ea8be3fef8
https://pubmed.ncbi.nlm.nih.gov/9525287

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Re-usable DNA template for the polymerase chain reaction

Autor: Sabina N. Sheikh, Philip Lazarus

DNA covalently bound to an uncharged nylon membrane was used for consecutive amplifications of several different genes by PCR. Successful PCR amplifications were obtained for membrane-bound genomic and plasmid DNA. Membrane-bound genomic DNA template

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::657b8e9d85268ddb43019c37716187dd
https://europepmc.org/articles/PMC146921/

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Heteromers of glutamate decarboxylase isoforms occur in rat cerebellum

Autor: Sabina N. Sheikh, David L. Martin

Publikováno v: Journal of neurochemistry. 66(5)

The subunit structure of brain glutamate decarboxylase in cerebellum was investigated by using gel electrophoresis and antisera that specifically recognize the individual isoforms of brain glutamate decarboxylase (termed GAD 65 and GAD 67 ). The anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858ae48338748431171ea4d4cc93aafd
https://pubmed.ncbi.nlm.nih.gov/8780039

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Effects of increased gamma-aminobutyric acid levels on GAD67 protein and mRNA levels in rat cerebral cortex

Autor: Sabina N. Sheikh, Karin Rimvall, David L. Martin

Publikováno v: Journal of neurochemistry. 60(2)

Rats were injected with saline or the gamma-aminobutyric acid (GABA) transaminase inhibitor gamma-vinyl-GABA for 7 days and the effects on GABA content and glutamic acid decarboxylase (GAD) activity, and the protein and mRNA levels of the two forms o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ab4eeaa1f4ee114234bc80e39600971
https://pubmed.ncbi.nlm.nih.gov/8419546

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