Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sabina Muend"'
Autor:
Jing Chen, Bo Xu, BoLei Li, Xu Cao, Jessica Dang, Siqi Chen, E Gulsen Gunes, Lei Tian, Sabina Muend, Mustafa Raoof, Christiane Querfeld, Jianhua Yu, Steven T. Rosen, Yingyu Wang, Mingye Feng
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
Background Limited therapeutic options are available for triple-negative breast cancer (TNBC), emphasizing an urgent need for more effective treatment approaches. The development of strategies by targeting tumor-associated macrophages (TAMs) to stimu
Externí odkaz:
https://doaj.org/article/31732d4dbcfd4f4c95dbaadf443a5ea4
Autor:
Sabina Muend, Rajini Rao
Publikováno v:
FEMS Yeast Research. 8:425-431
The antiarrhythmic drug amiodarone has microbicidal activity against fungi, bacteria and protozoa. In Saccharomyces cerevisiae, amiodarone triggers an immediate burst of cytosolic Ca 2+ , followed by cell death markers. Ca 2+ transients are a common
Publikováno v:
Frontiers in Neurology, Vol 5 (2014)
Frontiers in Neurology
Frontiers in Neurology
COMPLEX GENETIC ARCHITECTURE IN AUTISM Autism spectrum disorder (ASD) encompasses a range of early-onset neurodevelopmental disorders characterized by impaired social interactions and communications, together with repetitive stereotypic behaviors (MI
Publikováno v:
Frontiers in Microbiology
Frontiers in Microbiology, Vol 3 (2012)
Frontiers in Microbiology, Vol 3 (2012)
Ion-signaling and transduction networks are central to fungal development and virulence because they regulate gene expression, filamentation, host association, and invasion, pathogen stress response and survival. Dysregulation of ion homeostasis rapi
Manganese is a trace element that is an essential co-factor in many enzymes critical to diverse biological pathways. However, excess Mn(2+) leads to neurotoxicity, with psychiatric and motor dysfunction resembling parkinsonism. The liver is the main
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c4b418a377dc335e5018bbd7b48cd0
https://europepmc.org/articles/PMC3238027/
https://europepmc.org/articles/PMC3238027/
Publikováno v:
Antimicrobial agents and chemotherapy. 54(12)
Terpenoid phenols, including carvacrol, are components of oregano and other plant essential oils that exhibit potent antifungal activity against a wide range of pathogens, including Candida albicans , Staphylococcus aureus , and Pseudomonas aeruginos
Cationic amphipathic drugs, such as amiodarone, interact preferentially with lipid membranes to exert their biological effect. In the yeast Saccharomyces cerevisiae, toxic levels of amiodarone trigger a rapid influx of Ca(2+) that can overwhelm cellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed6471fa0a21e7245a24f7f5765eab7c
https://europepmc.org/articles/PMC2631971/
https://europepmc.org/articles/PMC2631971/
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 104(47)
Phylogenetic analysis of the cation/proton antiporter superfamily has uncovered a previously unknown clade of genes in metazoan genomes, including two previously uncharacterized human isoforms, NHA1 and NHA2, found in tandem on human chromosome 4. Th
The Golgi-localized Ca2+- and Mn2+-transporting ATPase Pmr1 is important for secretory pathway functions. Yeast mutants lacking Pmr1 show growth sensitivity to multiple drugs (amiodarone, wortmannin, sulfometuron methyl, and tunicamycin) and ions (Mn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd19fe33f6c420f020c133e95b0d9d32
https://europepmc.org/articles/PMC1839000/
https://europepmc.org/articles/PMC1839000/
Autor:
Yingyu Wang, Sharon Leitch, Gregory R. Monteith, Saraswati Sukumar, Sarah J. Roberts-Thomson, Nguyen Nguyen, Paraic A. Kenny, Sabina Muend, Rajini Rao, Desma Grice, Helen M. Faddy, Mingye Feng
Publikováno v:
Cell. (1):84-98
Ca(2+) is an essential and ubiquitous second messenger. Changes in cytosolic Ca(2+) trigger events critical for tumorigenesis, such as cellular motility, proliferation, and apoptosis. We show that an isoform of Secretory Pathway Ca(2+)-ATPase, SPCA2,