NaCl cotransporter abundance in urinary vesicles is increased by calcineurin inhibitors and predicts thiazide sensitivity.

Autor: Omar A Z Tutakhel, Arthur D Moes, Marco A Valdez-Flores, Marleen L A Kortenoeven, Mathijs V D Vrie, Sabina Jeleń, Robert A Fenton, Robert Zietse, Joost G J Hoenderop, Ewout J Hoorn, Luuk Hilbrands, René J M Bindels

Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0176220 (2017)

Animal studies have shown that the calcineurin inhibitors (CNIs) cyclosporine and tacrolimus can activate the thiazide-sensitive NaCl cotransporter (NCC). A common side effect of CNIs is hypertension. Renal salt transporters such as NCC are excreted

Externí odkaz: https://doaj.org/article/705850cf55534fe9a38c9803d808797d

Functionomics of NCC mutations in Gitelman syndrome using a novel mammalian cell-based activity assay

Autor: Anne Blanchard, Sjoerd Verkaart, Sabina Jeleń, Cyrielle Treard, René J. M. Bindels, Marco A. Valdez-Flores, Rosa Vargas-Poussou, Omar A. Z. Tutakhel, Angel Valdez-Ortiz, Joost G. J. Hoenderop

Publikováno v: American Journal of Physiology : Renal Physiology, 311, 6, pp. F1159-F1167
American Journal of Physiology : Renal Physiology, 311, F1159-F1167

Contains fulltext : 172535.pdf (Publisher’s version ) (Closed access) Gitelman syndrome (GS) is an autosomal recessive salt-wasting tubular disorder resulting from loss-of-function mutations in the thiazide-sensitive NaCl cotransporter (NCC). Funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daaf89efc2ab16b42dcd80e8a229911c
https://doi.org/10.1152/ajprenal.00124.2016

Alternative splice variant of the thiazide-sensitive NaCl cotransporter: a novel player in renal salt handling

Autor: Omar A. Z. Tutakhel, Jaap Deinum, René J. M. Bindels, Marco A. Valdez-Flores, Jacques W.M. Lenders, Henrik Dimke, Sander R. Piersma, Sabina Jeleń, Joost G. J. Hoenderop, Connie R. Jimenez

Publikováno v: Tutakhel, O A Z, Jelen, S, Valdez-Flores, M, Dimke, H, Piersma, S R, Jimenez, C R, Deinum, J, Lenders, J W, Hoenderop, J G J & Bindels, R J M 2016, ' Alternative splice variant of the thiazide-sensitive NaCl cotransporter: a novel player in renal salt handling ', American Journal of Physiology. Renal Physiology, vol. 310, no. 3, pp. F204-F216 . https://doi.org/10.1152/ajprenal.00429.2015
American Journal of Physiology : Renal Physiology, 310, 3, pp. F204-16
American Journal of Physiology : Renal Physiology, 310, F204-16
American Journal of Physiology. Renal Physiology, 310(3), F204-F216. American Physiological Society
Tutakhel, O A Z, Jeleń, S, Valdez-Flores, M, Dimke, H, Piersma, S R, Jimenez, C R, Deinum, J, Lenders, J W, Hoenderop, J G J & Bindels, R J M 2016, ' Alternative splice variant of the thiazide-sensitive NaCl cotransporter : a novel player in renal salt handling ', American Journal of Physiology: Renal Physiology, vol. 310, no. 3, pp. F204-F216 . https://doi.org/10.1152/ajprenal.00429.2015

The thiazide-sensitive NaCl cotransporter (NCC) is an important pharmacological target in the treatment of hypertension. The human SLC12A3 gene, encoding NCC, gives rise to three isoforms. Only the third isoform has been extensively investigated. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3cf436a2c73bedcb255dc3e4c7a7de
https://pubmed.ncbi.nlm.nih.gov/26561651

Marketising Slovene adult education policies and practices using mechanisms of the Europeanisation of education

Autor: Borut Mikulec, Sabina Jelenc Krašovec

Publikováno v: European Journal for Research on the Education and Learning of Adults, Vol 7, Iss 2, Pp 151-170 (2016)

This article addresses the issue of marketisation in the field of adult education by reflecting on the Europeanisation of education currently taking place through the establishment of European adult education policies. The article argues that Europea

Externí odkaz: https://doaj.org/article/f0f2bc5a463142d2bd776c55ac14281d

Book review: Researching and transforming adult learning and communities - the local/global context: By Rob Evans, Ewa Kurantowicz and Emilio Lucio-Villegas (Eds.). (Rotterdam, the Netherlands: Sense Publishers, 2016). 197 pp., ISBN 978-946300-357-5

Autor: Sabina Jelenc Krašovec

Publikováno v: European Journal for Research on the Education and Learning of Adults, Vol 7, Iss 1, Pp 135-137 (2016)

Not Available

Externí odkaz: https://doaj.org/article/21d13ef98bfc4a699fc080cf826d32ea