NaCl cotransporter abundance in urinary vesicles is increased by calcineurin inhibitors and predicts thiazide sensitivity.

Autor: Omar A Z Tutakhel, Arthur D Moes, Marco A Valdez-Flores, Marleen L A Kortenoeven, Mathijs V D Vrie, Sabina Jeleń, Robert A Fenton, Robert Zietse, Joost G J Hoenderop, Ewout J Hoorn, Luuk Hilbrands, René J M Bindels

Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0176220 (2017)

Animal studies have shown that the calcineurin inhibitors (CNIs) cyclosporine and tacrolimus can activate the thiazide-sensitive NaCl cotransporter (NCC). A common side effect of CNIs is hypertension. Renal salt transporters such as NCC are excreted

Externí odkaz: https://doaj.org/article/705850cf55534fe9a38c9803d808797d

Functionomics of NCC mutations in Gitelman syndrome using a novel mammalian cell-based activity assay

Autor: Anne Blanchard, Sjoerd Verkaart, Sabina Jeleń, Cyrielle Treard, René J. M. Bindels, Marco A. Valdez-Flores, Rosa Vargas-Poussou, Omar A. Z. Tutakhel, Angel Valdez-Ortiz, Joost G. J. Hoenderop

Publikováno v: American Journal of Physiology : Renal Physiology, 311, 6, pp. F1159-F1167
American Journal of Physiology : Renal Physiology, 311, F1159-F1167

Contains fulltext : 172535.pdf (Publisher’s version ) (Closed access) Gitelman syndrome (GS) is an autosomal recessive salt-wasting tubular disorder resulting from loss-of-function mutations in the thiazide-sensitive NaCl cotransporter (NCC). Funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daaf89efc2ab16b42dcd80e8a229911c
https://doi.org/10.1152/ajprenal.00124.2016

Alternative splice variant of the thiazide-sensitive NaCl cotransporter: a novel player in renal salt handling

Autor: Omar A. Z. Tutakhel, Jaap Deinum, René J. M. Bindels, Marco A. Valdez-Flores, Jacques W.M. Lenders, Henrik Dimke, Sander R. Piersma, Sabina Jeleń, Joost G. J. Hoenderop, Connie R. Jimenez

Publikováno v: Tutakhel, O A Z, Jelen, S, Valdez-Flores, M, Dimke, H, Piersma, S R, Jimenez, C R, Deinum, J, Lenders, J W, Hoenderop, J G J & Bindels, R J M 2016, ' Alternative splice variant of the thiazide-sensitive NaCl cotransporter: a novel player in renal salt handling ', American Journal of Physiology. Renal Physiology, vol. 310, no. 3, pp. F204-F216 . https://doi.org/10.1152/ajprenal.00429.2015
American Journal of Physiology : Renal Physiology, 310, 3, pp. F204-16
American Journal of Physiology : Renal Physiology, 310, F204-16
American Journal of Physiology. Renal Physiology, 310(3), F204-F216. American Physiological Society
Tutakhel, O A Z, Jeleń, S, Valdez-Flores, M, Dimke, H, Piersma, S R, Jimenez, C R, Deinum, J, Lenders, J W, Hoenderop, J G J & Bindels, R J M 2016, ' Alternative splice variant of the thiazide-sensitive NaCl cotransporter : a novel player in renal salt handling ', American Journal of Physiology: Renal Physiology, vol. 310, no. 3, pp. F204-F216 . https://doi.org/10.1152/ajprenal.00429.2015

The thiazide-sensitive NaCl cotransporter (NCC) is an important pharmacological target in the treatment of hypertension. The human SLC12A3 gene, encoding NCC, gives rise to three isoforms. Only the third isoform has been extensively investigated. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3cf436a2c73bedcb255dc3e4c7a7de
https://pubmed.ncbi.nlm.nih.gov/26561651

NaCl cotransporter abundance in urinary vesicles is increased by calcineurin inhibitors and predicts thiazide sensitivity.

Autor: Tutakhel, Omar A. Z.¹, Moes, Arthur D.², Valdez-Flores, Marco A.^1,3, Kortenoeven, Marleen L. A.⁴, Vrie, Mathijs v. D.⁵, Jeleń, Sabina¹, Fenton, Robert A.⁴, Zietse, Robert², Hoenderop, Joost G. J.¹, Hoorn, Ewout J.², Hilbrands, Luuk⁵, Bindels, René J. M.¹ rene.bindels@radboudumc.nl

Publikováno v: PLoS ONE. 4/21/2017, Vol. 12 Issue 4, p1-19. 19p.

Oxford Textbook of Clinical Nephrology

Autor: Neil N. Turner, Norbert Lameire, David J. Goldsmith, Christopher G. Winearls, Jonathan Himmelfarb, Giuseppe Remuzzi

This fourth edition of the Oxford Textbook of Clinical Nephrology builds on the success and international reputation of the publication as an important resource for the practising clinician in the field. It provides practical, scholarly, and evidence