Zobrazeno 1 - 3 of 3 pro vyhledávání: '"Sabina A. Lorca"'
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Akademický článek
Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in chronic constriction injury (CCI) rats
Autor: Jiahe Li, Harrison J. Stratton, Sabina A. Lorca, Peter M. Grace, Rajesh Khanna
Publikováno v: Channels, Vol 16, Iss 1, Pp 1-8 (2022)
The voltage-gated sodium channel isoform NaV1.7 is a critical player in the transmission of nociceptive information. This channel has been heavily implicated in human genetic pain disorders and is a validated pain target. However, targeting this chan
Externí odkaz: https://doaj.org/article/de479aade85b462b86d873237cce132f
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2
Preconditioning by voluntary wheel running attenuates later neuropathic pain via nuclear factor E2–related factor 2 antioxidant signaling in rats
Autor: Suzanne M. Green-Fulgham, Michael E. Harland, Jayson B. Ball, Jiahe Li, Michael J. Lacagnina, Heather D'Angelo, Renee A. Dreher, Kendal F. Willcox, Sabina A. Lorca, Andrew J. Kwilasz, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Publikováno v: Pain. 163:1939-1951
Animal and human studies have shown that exercise prior to nerve injury prevents later chronic pain, but the mechanisms of such preconditioning remain elusive. Given that exercise acutely increases the formation of free radicals, triggering antioxida
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9426a45a41a52f9e1117fa276bc989
https://doi.org/10.1097/j.pain.0000000000002589
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