Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Sabin Llona‐Minguez"'
Autor:
Si Min Zhang, Cynthia B.J. Paulin, Huazhang Shu, Miriam Yagüe-Capilla, Maurice Michel, Petra Marttila, Florian Ortis, Henri Colyn Bwanika, Christopher Dirks, Rajagopal Papagudi Venkatram, Elisée Wiita, Ann-Sofie Jemth, Ingrid Almlöf, Olga Loseva, Femke M. Hormann, Tobias Koolmeister, Erika Linde, Sun Lee, Sabin Llona-Minguez, Martin Haraldsson, Hanna Axelsson, Kia Strömberg, Evert J. Homan, Martin Scobie, Thomas Lundbäck, Thomas Helleday, Sean G. Rudd
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108907- (2024)
Summary: SAMHD1 is a dNTP triphosphohydrolase governing nucleotide pool homeostasis and can detoxify chemotherapy metabolites controlling their clinical responses. To understand SAMHD1 biology and investigate the potential of targeting SAMHD1 as neoa
Externí odkaz:
https://doaj.org/article/62a8b016c8c04843b50875f18c4706f6
Autor:
Brent D. G. Page, Nicholas C. K. Valerie, Roni H. G. Wright, Olov Wallner, Rebecka Isaksson, Megan Carter, Sean G. Rudd, Olga Loseva, Ann-Sofie Jemth, Ingrid Almlöf, Jofre Font-Mateu, Sabin Llona-Minguez, Pawel Baranczewski, Fredrik Jeppsson, Evert Homan, Helena Almqvist, Hanna Axelsson, Shruti Regmi, Anna-Lena Gustavsson, Thomas Lundbäck, Martin Scobie, Kia Strömberg, Pål Stenmark, Miguel Beato, Thomas Helleday
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
NUDIX hydrolases are an important family of nucleotide-metabolizing enzymes. Here, the authors identify potent, small molecule inhibitors of NUDT5, which is implicated in ADP-ribose and 8-oxo-guanine metabolism, and confirm its role in gene regulatio
Externí odkaz:
https://doaj.org/article/2bf99c4671d44e71969d21873ef164c4
Autor:
Sabin Llona-Minguez, Simon P. Mackay
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 1333-1338 (2014)
A convergent and stereoselective synthesis of chiral cyclopentyl- and cyclohexylamine derivatives of nucleoside Q precursor (PreQ0) has been accomplished. This synthetic route allows for an efficient preparation of 4-substituted analogues with intere
Externí odkaz:
https://doaj.org/article/f6a5198eb26f4f25862d9823e031a2fd
Autor:
Brent D. G. Page, Nicholas C. K. Valerie, Roni H. G. Wright, Olov Wallner, Rebecka Isaksson, Megan Carter, Sean G. Rudd, Olga Loseva, Ann-Sofie Jemth, Ingrid Almlöf, Jofre Font-Mateu, Sabin Llona-Minguez, Pawel Baranczewski, Fredrik Jeppsson, Evert Homan, Helena Almqvist, Hanna Axelsson, Shruti Regmi, Anna-Lena Gustavsson, Thomas Lundbäck, Martin Scobie, Kia Strömberg, Pål Stenmark, Miguel Beato, Thomas Helleday
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/8af88760aa3d4c38b6df8ba59624e3f1
Autor:
Jessica Baiget, Sabin Llona-Minguez, Stuart Lang, Simon P. MacKay, Colin J. Suckling, Oliver B. Sutcliffe
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 7, Iss 1, Pp 1407-1411 (2011)
The carboline ring system is an important pharmacophore found in a number of biologically important targets. Development of synthetic routes for the preparation of these compounds is important in order to prepare a range of analogues containing the c
Externí odkaz:
https://doaj.org/article/7eafbe07aa394bfcad65cac6184099fa
Autor:
Luke R. Odell, Bobo Skillinghaug, Christof Matt, Peng Wu, Tobias Koolmeister, Matthieu Desroses, Sabin Llona‐Minguez, Olov Wallner, Thomas Helleday, Martin Scobie
Publikováno v:
European Journal of Organic Chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b1688af18df4f2f758494a48da62b37
https://doi.org/10.1002/ejoc.202300291
https://doi.org/10.1002/ejoc.202300291
Autor:
Nadilly Bonagas, Nina M. S. Gustafsson, Martin Henriksson, Petra Marttila, Robert Gustafsson, Elisée Wiita, Sanjay Borhade, Alanna C. Green, Karl S. A. Vallin, Antonio Sarno, Richard Svensson, Camilla Göktürk, Therese Pham, Ann-Sofie Jemth, Olga Loseva, Victoria Cookson, Nicole Kiweler, Lars Sandberg, Azita Rasti, Judith E. Unterlass, Martin Haraldsson, Yasmin Andersson, Emma R. Scaletti, Christoffer Bengtsson, Cynthia B. J. Paulin, Kumar Sanjiv, Eldar Abdurakhmanov, Linda Pudelko, Ben Kunz, Matthieu Desroses, Petar Iliev, Katarina Färnegårdh, Andreas Krämer, Neeraj Garg, Maurice Michel, Sara Häggblad, Malin Jarvius, Christina Kalderén, Amanda Bögedahl Jensen, Ingrid Almlöf, Stella Karsten, Si Min Zhang, Maria Häggblad, Anders Eriksson, Jianping Liu, Björn Glinghammar, Natalia Nekhotiaeva, Fredrik Klingegård, Tobias Koolmeister, Ulf Martens, Sabin Llona-Minguez, Ruth Moulson, Helena Nordström, Vendela Parrow, Leif Dahllund, Birger Sjöberg, Irene L. Vargas, Duy Duc Vo, Johan Wannberg, Stefan Knapp, Hans E. Krokan, Per I. Arvidsson, Martin Scobie, Johannes Meiser, Pål Stenmark, Ulrika Warpman Berglund, Evert J. Homan, Thomas Helleday
Publikováno v:
Nature Cancer
The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully characterized, and current candidate inhibitors have limited potency for clinical develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc803a4ce48681e11987b33fd0a94af
https://doi.org/10.1038/s43018-022-00331-y
https://doi.org/10.1038/s43018-022-00331-y
Autor:
Pål Stenmark, Thomas Helleday, Evert Homan, Yasmin Andersson, Martin Henriksson, Maria Häggblad, Sabin Llona-Minguez, Leif Dahllund, Nadilly Bonagas, Elisée Wiita, Olga Loseva, Katarina Färnegårdh, Nina M.S. Gustafsson, Ann-Sofie Jemth, Robert Gustafsson
Description of additional methods and procedures used in the study. Also includes Supplementary References.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0bc9eb2d0df2cb71d1f9ae89c01980c
https://doi.org/10.1158/0008-5472.22414458
https://doi.org/10.1158/0008-5472.22414458
Autor:
Pål Stenmark, Thomas Helleday, Evert Homan, Yasmin Andersson, Martin Henriksson, Maria Häggblad, Sabin Llona-Minguez, Leif Dahllund, Nadilly Bonagas, Elisée Wiita, Olga Loseva, Katarina Färnegårdh, Nina M.S. Gustafsson, Ann-Sofie Jemth, Robert Gustafsson
Buffers for MTHFD2 and MTHFD1 DC-domain lysis, purification and inhibition assay.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b582a3653a74d99a229e83fd3a02ea1e
https://doi.org/10.1158/0008-5472.22414455
https://doi.org/10.1158/0008-5472.22414455
Autor:
Pål Stenmark, Thomas Helleday, Evert Homan, Yasmin Andersson, Martin Henriksson, Maria Häggblad, Sabin Llona-Minguez, Leif Dahllund, Nadilly Bonagas, Elisée Wiita, Olga Loseva, Katarina Färnegårdh, Nina M.S. Gustafsson, Ann-Sofie Jemth, Robert Gustafsson
To sustain their proliferation, cancer cells become dependent on one-carbon metabolism to support purine and thymidylate synthesis. Indeed, one of the most highly upregulated enzymes during neoplastic transformation is MTHFD2, a mitochondrial methyle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27b1c130815606c4da40d07eee51a98b
https://doi.org/10.1158/0008-5472.c.6508983.v1
https://doi.org/10.1158/0008-5472.c.6508983.v1