Výsledky vyhledávání - "Sabiha S Chowdhury"

Akademický článek

Significant expansion of the donor pool achieved by utilizing islets of variable quality in the production of allogeneic 'Neo-Islets', 3-D organoids of Mesenchymal Stromal and islet cells, a novel immune-isolating biotherapy for Type I Diabetes.

Autor: Anna M Gooch, Sabiha S Chowdhury, Ping M Zhang, Zhuma M Hu, Christof Westenfelder

Publikováno v: PLoS ONE, Vol 18, Iss 8, p e0290460 (2023)

Novel biotherapies for Type 1 Diabetes that provide a significantly expanded donor pool and that deliver all islet hormones without requiring anti-rejection drugs are urgently needed. Scoring systems have improved islet allotransplantation outcomes,

Externí odkaz: https://doaj.org/article/5a20b0fa35cc443aa8a856532cd5a134

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Akademický článek

Administration of Nicotinamide Mononucleotide (NMN) Reduces Metabolic Impairment in Male Mouse Offspring from Obese Mothers

Autor: Golam M. Uddin, Neil A. Youngson, Sabiha S. Chowdhury, Christopher Hagan, David A. Sinclair, Margaret J. Morris

Publikováno v: Cells, Vol 9, Iss 4, p 791 (2020)

Maternal obesity impacts offspring metabolism. We sought to boost mitochondrial energy metabolism using the nicotinamide adenine dinucleotide (NAD+) precursor nicotinamide mononucleotide (NMN) to treat metabolic impairment induced by maternal and lon

Externí odkaz: https://doaj.org/article/49d6cd3e39e64799b18ba6c56b1d7e2b

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840-P: Proof of Concept of I.P. Administered Neo-Islet (NI) T1DM Biotherapy: Omentum Becomes the New Endocrine Pancreas by Spontaneous Redifferentiation of In Vitro Dedifferentiated Islet Cells

Autor: ANNA GOOCH, SABIHA S. CHOWDHURY, CHRISTOF WESTENFELDER

Publikováno v: Diabetes. 71

We published that treatment with allogeneic, species specific NIs, organoids of Mesenchymal Stromal Cells (MSCs) and culture expanded islet cells (ICs) functionally cured/improved the diabetic state in NOD mice, insulin dependent pet dogs, and NOD/SC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5026bb7925a946a359521ddc89de9ef2
https://doi.org/10.2337/db22-840-p

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841-P: Scientific Basis for the First-in-Human Trial of 'Neo-Islet'–Mediated Functional Cure of T1DM: The Intraperitoneal Administration of 'Neo-Islets,' 3-D Organoids of Allogeneic Islet and Mesenchymal Stromal Cells from Rodents, Dogs, and Humans Durably Cures

Autor: CHRISTOF WESTENFELDER, SABIHA S. CHOWDHURY, ANNA GOOCH

Publikováno v: Diabetes. 71

Initial reports from Clinical Trials with cell-based interventions for the urgently needed therapy of T1DM show: (1) An open, s.c.-placed encapsulation device containing insulin-producing progenitor cells that require anti-rejection drugs has failed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72e806b68a17f78af4828b155e01399b
https://doi.org/10.2337/db22-841-p

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760-P: Allogeneic 'Neo-Islets,' Organoids Composed of Cultured Pancreatic Islet and Mesenchymal Stromal Cells from Diverse Donors, Afford a Marked Increase in the Global Availability of a Curative, Novel, Anti-Rejection-Drug-Independent Biotherapy of T1DM

Autor: Christof Westenfelder, Sabiha S. Chowdhury, Anna Gooch

Publikováno v: Diabetes. 70

The scarcity of suitable pancreas/islet donors, the life-long need for potentially toxic anti-rejection drugs for transplants and certain biotherapies, and failure of some immune-isolating encapsulation devices collectively warrant the urgent develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::177cbfd84a762c72d48c6511c1f9c8f7
https://doi.org/10.2337/db21-760-p

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203-LB: Redosing of Suboptimally Controlled Diabetic Mice with Human Neo-islets, 3D Aggregates of Mesenchymal Stromal and Pancreatic Islet Cells, Durably Restores Euglycemia: Relevance to the Treatment of Diabetic Humans

Autor: Zhuma Hu, Sabiha S. Chowdhury, Anna Gooch, Christof Westenfelder, Ping Zhang

Publikováno v: Diabetes. 69

We reported that the i.p. administration of allogeneic Neo-Islets (NIs; 3D aggregates of allogeneic, culture-expanded Islet cells (ICs) with immune- and cyto-protective Mesenchymal Stromal Cells (MSCs)), durably restores normoglycemia in autoimmune t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74d826a2757aa51ef1f35b434a2b8f0d
https://doi.org/10.2337/db20-203-lb

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204-LB: The In Vitro Characteristics of Human Islet Cells from Diverse Donors, Coaggregated with Human Mesenchymal Stromal Cells to form 'Neo-islets', Are Consistently Identical: Relevance to Clinical Trials in Diabetic Subjects

Autor: Christof Westenfelder, Zhuma Hu, Ping Zhang, Sabiha S. Chowdhury, Anna Gooch

Publikováno v: Diabetes. 69

We reported that allogeneic “Neo-Islets” (NIs), organoids composed of ~ equal numbers of Mesenchymal Stromal Cells and culture expanded Islet Cells (ICs) do, when given i.p., omentally engraft and permanently restore euglycemia in auto-immune dia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f6aa1de8f636a8c6740b17b6d6b9330
https://doi.org/10.2337/db20-204-lb

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Administration of Nicotinamide Mononucleotide (NMN) Reduces Metabolic Impairment in Male Mouse Offspring from Obese Mothers

Autor: Neil A. Youngson, Sabiha S. Chowdhury, David A. Sinclair, Golam M. Uddin, Christopher Hagan, Margaret J. Morris

Publikováno v: Cells
Cells, Vol 9, Iss 4, p 791 (2020)
Volume 9
Issue 4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40a5693c36f92d2f891d7c4e4a138ef
http://europepmc.org/articles/PMC7226525

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614-P: Optimal Control of Glucose and Lipid Profiles Is Critical to the Effective 'Neo-Islet' Therapy of Insulin Dependent Pet Dogs

Autor: Sabiha S. Chowdhury, Anna Gooch, Christof Westenfelder

Publikováno v: Diabetes. 68

We demonstrated that ip administration of “Neo-Islets” (NIs; co-aggregation of allogeneic, culture-expanded Islet cells (ICs) with Adipose derived Stem Cells (ASCs)), resulted in their omental engraftment in immune-competent, diabetic NOD mice. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e65563b7f2c10101d60491112a895ad
https://doi.org/10.2337/db19-614-p

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262-OR: INAD 012-776 Pilot Study: Allogeneic 'Neo-Islets,' Composed of Mesenchymal Stem and Islet Cells, Are Immune Protected and Dose-Dependently and Durably Control Autoimmune T1DM in Pet Dogs

Autor: Anna Gooch, Sabiha S. Chowdhury, Christof Westenfelder

Publikováno v: Diabetes. 68

We demonstrated that allogeneic, ip administered “Neo-Islets” (NIs), aggregates of cultured islet cells (ICs) and immune- and cyto-protective Adipose Derived Stem Cells (ASCs), reestablished durable normoglycemia through omental engraftment and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::304fe1e7b9dbc2799e9d795fd1d2fcaa
https://doi.org/10.2337/db19-262-or

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