Sex-dependent interactions between prodromal intestinal inflammation and LRRK2 G2019S in mice promote endophenotypes of Parkinson’s disease

Autor: Ping Fang, Lewis W. Yu, Hannah Espey, Gulistan Agirman, Sabeen A. Kazmi, Kai Li, Yongning Deng, Jamie Lee, Haley Hrncir, Arlene Romero-Lopez, Arthur P. Arnold, Elaine Y. Hsiao

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)

Abstract Gastrointestinal (GI) disruptions and inflammatory bowel disease (IBD) are commonly associated with Parkinson’s disease (PD), but how they may impact risk for PD remains poorly understood. Herein, we provide evidence that prodromal intesti

Externí odkaz: https://doaj.org/article/22802ff0438a46cbb243b0fef4b00175

Extending genetic risk for Alzheimer’s disease from host to holobiont

Autor: Sabeen A. Kazmi, Elaine Y. Hsiao

Publikováno v: Cell. 186:690-692

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11abcf74c56ed4b6ea614b8d574862f5
https://doi.org/10.1016/j.cell.2023.01.004

Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCA*A53T) mouse lines

Autor: Steve M. Gentleman, Glenda M. Halliday, Amanda L. Woerman, Steven H. Olson, Daniel A. Mordes, Lea T. Grinberg, Sabeen A. Kazmi, Abby Oehler, Lefkos T. Middleton, Stanley B. Prusiner, Jisoo Lee, Salvatore Spina

Publikováno v: Acta neuropathologica, vol 137, iss 3
Woerman, Amanda L; Oehler, Abby; Kazmi, Sabeen A; Lee, Jisoo; Halliday, Glenda M; Middleton, Lefkos T; et al.(2019). Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCA*A53T) mouse lines.. Acta neuropathologica, 137(3), 437-454. doi: 10.1007/s00401-019-01959-4. UCSF: Retrieved from: http://www.escholarship.org/uc/item/6b83f3sn

Previously, we reported that intracranial inoculation of brain homogenate from multiple system atrophy (MSA) patient samples produces neurological disease in the transgenic (Tg) mouse model TgM83(+/−), which uses the prion protein promoter to expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576b24dedb6ac049bdb76c707c8a561f
https://escholarship.org/uc/item/6b83f3sn

Familial Parkinson's point mutation abolishes multiple system atrophy prion replication

Autor: Steven H. Olson, Sabeen A. Kazmi, Smita S. Patel, Kartika Widjaja, Daniel A. Mordes, Amanda L. Woerman, Atsushi Aoyagi, Stanley B. Prusiner, Abby Oehler

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 115(2)

Significance In Parkinson’s disease (PD) and multiple system atrophy (MSA), the accumulation and spread of α-synuclein prions leads to the progressive degeneration seen in patients. These diseases are thought to arise from unique conformations of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2136521e9b972dbe1e9bd5f1ddef738f
https://pubmed.ncbi.nlm.nih.gov/29279394

Tau prions from Alzheimer’s disease and chronic traumatic encephalopathy patients propagate in cultured cells

Autor: Sabeen A. Kazmi, Steven H. Olson, Smita S. Patel, Iryna Lobach, Ann C. McKee, Stanley B. Prusiner, Amanda L. Woerman, William W. Seeley, Lea T. Grinberg, Atsushi Aoyagi

Publikováno v: Proceedings of the National Academy of Sciences. 113

Tau prions are thought to aggregate in the central nervous system, resulting in neurodegeneration. Among the tauopathies, Alzheimer's disease (AD) is the most common, whereas argyrophilic grain disease (AGD), corticobasal degeneration (CBD), chronic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a57befd88166031908067c06aadf538
https://doi.org/10.1073/pnas.1616344113