Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Sabarni K Chatterjee"'
Autor:
Ivy Chung, Bruce R. Zetter, Chunyao Jenny Mu, Nish Patel, Vladimir Vrbanac, Rachelle R. Olsen, Sabarni K. Chatterjee, Carol G. Waghorne
Publikováno v:
Proceedings of the National Academy of Sciences. 107:2503-2508
Paclitaxel has emerged as a front line treatment for aggressive malignancies of the breast, lung, and ovary. Successful therapy of cancer is frequently undermined by the development of paclitaxel resistance. There is a growing need to find other ther
Autor:
Bruce R. Zetter, Sabarni K Chatterjee
Publikováno v:
Future Oncology. 1:37-50
In recent years the discovery of cancer biomarkers has become a major focus of cancer research. The widespread use of prostate-specific antigen in prostate cancer screening has motivated researchers to identify suitable markers for screening differen
Autor:
David G. I. Kingston, Donna M Barron, Susan Bane, Sabarni K. Chatterjee, Rudravajhala Ravindra, Rebecca Roof, Erkan Baloglu
Publikováno v:
Analytical Biochemistry. 315:49-56
With the advent of combinatorial chemistry and the extensive libraries of potential drugs produced from it, there is a growing need for rapid sensitive, high-throughput screening for drug potency. Microtubules are important targets for anticancer age
Autor:
Erkan Baloglu, Rudravajhala Ravindra, David G. I. Kingston, Jeannine Hoch, Susan Bane, Sabarni K. Chatterjee
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:1557-1568
Concurrent modifications on the C-3'NH/C-10, and C-2/C-10 positions on paclitaxel were carried out as a way of investigating possible synergistic effects. The biological activities of these analogues were evaluated in both a microtubule assembly assa
Publikováno v:
Nature biotechnology. 32(1)
Compared with other US public-sector research institutions, the US National Institutes of Health has contributed inventions that have had a disproportionately greater impact on the overall number of products produced, drugs granted orphan status and
Autor:
David G. I. Kingston, Ami Lakdawala, Jeannine Hoch, James P. Snyder, Susan Bane, Sabarni K. Chatterjee, Thomas E. Glass, Ben Cornett, Belhu B. Metaferia
Publikováno v:
Organic Letters. 3:2461-2464
[reaction: see text] This work describes the synthesis of two novel macrocyclic taxoid constructs by ring-closing olefin metathesis (RCM) and their biological evaluation. Computational studies examine conformational profiles of 1 and 2 for their fit
Publikováno v:
Biochemistry. 40:6964-6970
Baccatin III is widely considered to be an inactive derivative of Taxol. We have reexamined its effect on in vitro assembly of tubulin under a variety of conditions. We found baccatin III to be active in all circumstances in which Taxol is active: it
Autor:
James P. Snyder, David G. I. Kingston, Ami Lakdawala, Belhu B. Metaferia, Susan Bane, Sabarni K. Chatterjee, Jeannine Hoch, Thomas E. Glass, Ben Cornett
Publikováno v:
ChemInform. 32
This work describes the synthesis of two novel macrocyclic taxoid constructs by ring-closing olefin metathesis (RCM) and their biological evaluation. Computational studies examine conformational profiles of 1 and 2 for their fit to the β-tubulin bin
Publikováno v:
ChemInform. 32
The preparation of two new fluorescent derivatives of paclitaxel in which the fluorophore is bonded to paclitaxel at the C-10 position is reported. Both analogues, 10-deacetyl-10-(m-aminobenzoyl)paclitaxel (1, BTax) and 10-deacetyl-10-[7-(diethylamin
Autor:
Rudravajhala Ravindra, Julien Laffray, Martin E. Kuehne, Pruthvi Patel, Yong Qin, Susan Bane, Sabarni K. Chatterjee
Publikováno v:
Biochemistry. 41(47)
Vinblastine is an antimitotic agent that has been used extensively in cancer chemotherapy. The biological effects of the drug are believed to be the result of its interaction with tubulin, the major component of cellular microtubules. Fluorescence sp