Výsledky vyhledávání - "Sabahuddin, Ahmad"

Akademický článek

Novel Non-Peptide Inhibitors against SmCL1 of Schistosoma mansoni: In Silico Elucidation, Implications and Evaluation via Knowledge Based Drug Discovery.

Autor: Atif Zafar, Sabahuddin Ahmad, Asim Rizvi, Masood Ahmad

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0123996 (2015)

Schistosomiasis is a major endemic disease known for excessive mortality and morbidity in developing countries. Because praziquantel is the only drug available for its treatment, the risk of drug resistance emphasizes the need to discover new drugs f

Externí odkaz: https://doaj.org/article/ad9852fc9bd048a4852d2d4e812d26d8

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Substrate access mechanism in a novel membrane-bound phospholipase A of Pseudomonas aeruginosa concordant with specificity and regioselectivity

Autor: Filip Kovacic, Christoph Heinrich Strunk, Stephan Schott-Verdugo, Sabahuddin Ahmad, Karl-Erich Jaeger, Holger Gohlke

PlaF is a cytoplasmic membrane-bound phospholipase A1 from Pseudomonas aeruginosa that alters the membrane glycerophospholipid (GPL) composition and fosters the virulence of this human pathogen. PlaF activity is regulated by a dimer-to-monomer transi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a842beb2e8f21621df869bfc5a63f089
https://doi.org/10.1101/2021.06.29.450291

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Interaction of C20-substituted derivative of pregnenolone acetate with copper (II) leads to ROS generation, DNA cleavage and apoptosis in cervical cancer cells: Therapeutic potential of copper chelation for cancer treatment

Autor: Sabahuddin Ahmad, Mohammad Imran Siddiqi, Saman Khan, Swarnendra Singh, Atif Zafar, Imrana Naseem

Publikováno v: Bioorganic Chemistry. 87:276-290

Cervical cancer is a leading cause of cancer-related deaths among women in developing countries. Therefore, development of new chemotherapeutic agents is required. Unlike normal cells, cancer cells contain elevated copper levels which play an integra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00296806cc76c91de5ab98326ddee1d4
https://doi.org/10.1016/j.bioorg.2019.03.031

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Substrate Access Mechanism in a Novel Membrane-Bound Phospholipase A of Pseudomonas aeruginosa Concordant with Specificity and Regioselectivity

Autor: Stephan Schott-Verdugo, Christoph Heinrich Strunk, Sabahuddin Ahmad, Holger Gohlke, Filip Kovacic, Karl-Erich Jaeger

Publikováno v: Journal of chemical information and modeling 61(11), 5626–5643 (2021). doi:10.1021/acs.jcim.1c00973

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc1f1c2f75e9dfc8d65b64986ad4fd9d
https://juser.fz-juelich.de/record/902474

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Physico-chemical and in-silico analysis of a phytocystatin purified fromBrassica junceacultivar RoAgro 5444

Autor: Mohammad Imran Siddiqi, Shumaila Khan, Bilqees Bano, Sabahuddin Ahmad

Publikováno v: Biochemistry and Cell Biology. 94:584-596

This study describes the isolation and purification of a phytocystatin from seeds of Brassica juncea (Indian mustard; cultivar RoAgro 5444), which is an important oilseed crop both agriculturally and economically. The protein was purified by gel filt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892eb1995a0ab211b14f5debe135fa42
https://doi.org/10.1139/bcb-2016-0029

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Molecular modeling assisted identification and biological evaluation of potent cathepsin S inhibitors

Autor: Sabahuddin Ahmad, Sudha Bhagwati, Dibyendu Banerjee, Sushil Kumar, Mohammad Imran Siddiqi

Publikováno v: Journal of molecular graphicsmodelling. 96

Cathepsin S (CatS) is one of the cysteinyl cathepsins widely studied for its clinical significance and found to be a promising therapeutic target for several diseases; to name a few is arthritis, allergic inflammation, cancer, diabetes, obesity, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b72c3cabe1c9582a0bb9b7c7a2a53e2a
https://pubmed.ncbi.nlm.nih.gov/31881466

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Nutrient exchange in arbuscular mycorrhizal symbiosis from a thermodynamic point of view

Autor: Alga Zuccaro, Ingo Dreyer, Stephan Schott-Verdugo, Marco A. Molina-Montenegro, Sabahuddin Ahmad, María E Rubio-Meléndez, Lutz Schmitt, Olivia Spitz, Kerstin Kanonenberg, Maria Handrich, Petra Bauer, Antonella Succurro, Holger Gohlke, Janin Riedelsberger, Sven B. Gould, Karolin Montag, Carlos Navarro-Retamal, Judith Lucia Gomez-Porras

Publikováno v: The new phytologist 222(2), 1043-1053 (2019). doi:10.1111/nph.15646
The New Phytologist

To obtain insights into the dynamics of nutrient exchange in arbuscular mycorrhizal (AM) symbiosis, we modelled mathematically the two‐membrane system at the plant–fungus interface and simulated its dynamics. In computational cell biology experim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85faba0e064ce262b85bed328a3ee355
https://juser.fz-juelich.de/record/859030

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A TLR4-derived non-cytotoxic, self-assembling peptide functions as a vaccine adjuvant in mice

Autor: Shailja Misra Bhattacharya, Anshika Tandon, Mohd Sayeed, Mohammad Imran Siddiqi, Sabahuddin Ahmad, Munesh Kumar Harioudh, Kalyan Mitra, Jimut Kanti Ghosh, Tayyaba Afshan, Manisha Pathak

Publikováno v: The Journal of biological chemistry. 293(51)

Vaccination is devised/formulated to stimulate specific and prolonged immune responses for long-term protection against infection or disease. A vaccine component, namely adjuvant, enhances antigen recognition by the host immune system and thereby sti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3987bb61457ee255b09ee912d66a7da9
https://pubmed.ncbi.nlm.nih.gov/30385503

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