Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Sabah N. A. Hussain"'
Autor:
Jean-Philippe Leduc-Gaudet, Anais Franco-Romero, Marina Cefis, Alaa Moamer, Felipe E. Broering, Giulia Milan, Roberta Sartori, Tomer Jordi Chaffer, Maude Dulac, Vincent Marcangeli, Dominique Mayaki, Laurent Huck, Anwar Shams, José A. Morais, Elise Duchesne, Hanns Lochmuller, Marco Sandri, Sabah N. A. Hussain, Gilles Gouspillou
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Here, the authors identify a novel regulator of autophagy, skeletal muscle mass and integrity named MYTHO. Silencing MYTHO protects against muscle atrophy in a wide range of acute catabolic conditions, while prolonged silencing causes a severe myopat
Externí odkaz:
https://doaj.org/article/20ed78ff3f19495c9028668e5c96dfd4
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Background: Long non-coding RNAs (lncRNAs) are non-coding RNAs that have more than 200 nucleotides. They have recently emerged as important regulators of angiogenesis. To identify novel lncRNAs that may be involved in the regulation of angiogenesis,
Externí odkaz:
https://doaj.org/article/775e1940f3f84791a3e01b33175ba16a
Autor:
Sharon Harel, Veronica Sanchez, Alaa Moamer, Javier E. Sanchez-Galan, Mohammad N. Abid Hussein, Dominique Mayaki, Mathieu Blanchette, Sabah N. A. Hussain
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
BackgroundAngiopoietin-1 (Ang-1) is the main ligand of Tie-2 receptors. It promotes endothelial cell (EC) survival, migration, and differentiation. Little is known about the transcription factors (TFs) in ECs that are downstream from Tie-2 receptors.
Externí odkaz:
https://doaj.org/article/f3899ee968d44985baad7e2ba6141391
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/6f16262062744cb0a841c9a3c4a0a1c0
Autor:
Brenda Janice Sánchez, Anne-Marie K. Tremblay, Jean-Philippe Leduc-Gaudet, Derek T. Hall, Erzsebet Kovacs, Jennifer F. Ma, Souad Mubaid, Patricia L. Hallauer, Brittany L. Phillips, Katherine E. Vest, Anita H. Corbett, Dimitris L. Kontoyiannis, Sabah N. A. Hussain, Kenneth E. M. Hastings, Sergio Di Marco, Imed-Eddine Gallouzi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
HuR is an RNA-binding protein that regulates myotube differentiation in vitro. Here, the authors show that the muscle-specific ablation of HuR in mice leads to enhanced endurance capacity and an increase in oxidative fibres by destabilising PGC1α-mR
Externí odkaz:
https://doaj.org/article/abbd8d839dcd49f5a47e7010f27a777f
Autor:
Feng Liang, Guillaume Emeriaud, Dilson E. Rassier, Dong Shang, Ekaterina Gusev, Sabah N. A. Hussain, Michael Sage, Benjamin Crulli, Etienne Fortin-Pellerin, Jean-Paul Praud, Basil J. Petrof
Publikováno v:
Critical Care, Vol 23, Iss 1, Pp 1-10 (2019)
Abstract Background Diaphragm weakness occurs rapidly in adult animals treated with mechanical ventilation (MV), but the effects of MV on the neonatal diaphragm have not been determined. Furthermore, it is unknown whether co-existent lung disease exa
Externí odkaz:
https://doaj.org/article/936b198f33944622bcd44ba3a219c342
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 8179 (2021)
The maintenance of mitochondrial integrity is critical for muscle health. Mitochondria, indeed, play vital roles in a wide range of cellular processes, including energy supply, Ca2+ homeostasis, retrograde signaling, cell death, and many others. All
Externí odkaz:
https://doaj.org/article/bebf7fd3b3754b6dafd187f89b42136f
Autor:
Vanessa Moarbes, Dominique Mayaki, Laurent Huck, Philippe Leblanc, Theodoros Vassilakopoulos, Basil J. Petrof, Sabah N. A. Hussain
Publikováno v:
Physiological Reports, Vol 7, Iss 20, Pp n/a-n/a (2019)
Abstract Sepsis elicits skeletal muscle atrophy as a result of decreased total protein synthesis and/or increased total protein degradation. It is unknown how and whether sepsis differentially affects the expression of specific myofibrillar proteins
Externí odkaz:
https://doaj.org/article/c1a6190db40244c5a5fd5408c913dbe5
Autor:
Jean-Philippe Leduc-Gaudet, Dominique Mayaki, Olivier Reynaud, Felipe E. Broering, Tomer J. Chaffer, Sabah N. A. Hussain, Gilles Gouspillou
Publikováno v:
Cells, Vol 9, Iss 6, p 1454 (2020)
Sepsis elicits skeletal muscle weakness and fiber atrophy. The accumulation of injured mitochondria and depressed mitochondrial functions are considered as important triggers of sepsis-induced muscle atrophy. It is unclear whether mitochondrial dysfu
Externí odkaz:
https://doaj.org/article/011d7d8484c64d209a464384b0cc9ab3
Autor:
Olivier Reynaud, Jennifer Wang, Marie-Belle Ayoub, Jean-Philippe Leduc-Gaudet, Dominique Mayaki, Maude Dulac, Sabah N. A. Hussain, Raynald Bergeron, Gilles Gouspillou
Publikováno v:
American Journal of Physiology-Cell Physiology. 324:C366-C376
Obesity is a major risk factor for developing various health problems, including insulin resistance and type 2 diabetes. Although controversial, accumulation of mitochondrial dysfunction, and notably an increase in mitochondrial reactive oxygen speci