Výsledky vyhledávání - "Saba Saqlain"

REST Protects Dopaminergic Neurons from Mitochondrial and α-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing BAC-Transgenic Mouse Model

Autor: Gabriele Corda, Helle Bogtofte, Saba Saqlain, Brent J. Ryan, Milena Cioroch, Richard Wade-Martins, Ecem Kirkiz, Nora Bengoa-Vergniory, Maximilian Sloan, Rosalind F. Roberts, Matthew Williamson, Marta Cherubini, Josse Poppinga, Svenja Hester

Publikováno v: The Journal of Neuroscience. 41:3731-3746

Alpha-synuclein pathology is associated with dopaminergic neuronal loss in the substantia nigra (SN) of Parkinson's patients. Working across human and mouse models, we investigated mechanisms by which the accumulation of soluble α-synuclein oligomer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f961220773ab60a6921281d98eed50
https://doi.org/10.1523/jneurosci.1478-20.2021

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Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich’s ataxia patient cells

Autor: R Mazzone, A Donato, Fengling Li, Saba Saqlain, G Vilema-Enríquez, Paul Brennan, Richard Wade-Martins, I Del Molino Del Barrio, Gabriele Corda, Andrea H. Németh, Masoud Vedadi, Peter Kilfeather, R Quinlan

Publikováno v: The Journal of Biological Chemistry

The molecular mechanisms of reduced frataxin (FXN) expression in Friedreich’s ataxia (FRDA) are linked to epigenetic modification of the FXN locus caused by the disease-associated GAA expansion. Here, we identify that SUV4-20 histone methyltransfer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a73730d4720115f745d901e60592221
https://doi.org/10.1101/2020.03.26.010439

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