Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Saba Ferdous"'
Autor:
Alicia-Marie Conway, Simon P. Pearce, Alexandra Clipson, Steven M. Hill, Francesca Chemi, Dan Slane-Tan, Saba Ferdous, A. S. Md Mukarram Hossain, Katarzyna Kamieniecka, Daniel J. White, Claire Mitchell, Alastair Kerr, Matthew G. Krebs, Gerard Brady, Caroline Dive, Natalie Cook, Dominic G. Rothwell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Cancers of Unknown Primary (CUP) remains a diagnostic and therapeutic challenge due to biological heterogeneity and poor responses to standard chemotherapy. Predicting tissue-of-origin (TOO) molecularly could help refine this diagnosis, with
Externí odkaz:
https://doaj.org/article/d4bcd616a1c54d2c97e8ef0bccad3ec9
Publikováno v:
Molecular Immunology. 114:643-650
Peptide vaccines have many potential advantages over conventional ones including low cost, lack of need for cold-chain storage, safety and specificity. However, it is well known that approximately 90% of B-cell epitopes (BCEs) are discontinuous in na
Autor:
Saba Ferdous, Charles Swanton, Francesca Chemi, Chang Sik Kim, Selvaraju Veeriah, Ged Brady, Sakshi Gulati, Deborah J. Burt, Mariam Jamal-Hanjani, Fiona H Blackhall, Daniel Slane-Tan, Nicholas McGranahan, Jackie Pierce, Marek Dynowski, Crispin J. Miller, Barbara Mesquita, Dominic G. Rothwell, Cong Zhou, David Allan Moore, Simon P. Pearce, Fabio Gomes, Philip A.J. Crosbie, Jonathan Tugwood, Nicolai Juul Birkbak, R. Shah, Gareth A. Wilson, Christopher Abbosh, Sophia Ward, Maise Al Bakir, Allan Hackshaw, Crispin T. Hiley, Caroline Dive, Dhruva Biswas, Yvonne Summers
Publikováno v:
Chemi, F, Rothwell, D G, McGranahan, N, Gulati, S, Abbosh, C, Pearce, S P, Zhou, C, Wilson, G A, Jamal-Hanjani, M, Birkbak, N, Pierce, J, Kim, C S, Ferdous, S, Burt, D J, Slane-Tan, D, Gomes, F, Moore, D, Shah, R, Al Bakir, M, Hiley, C, Veeriah, S, Summers, Y, Crosbie, P, Ward, S, Mesquita, B, Dynowski, M, Biswas, D, Tugwood, J, Blackhall, F, Miller, C, Hackshaw, A, Brady, G, Swanton, C, Dive, C & TRACERx Consortium 2019, ' Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse ', Nature Medicine, vol. 25, no. 10, pp. 1534-1539 . https://doi.org/10.1038/s41591-019-0593-1
TRACERx Consortium 2019, ' Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse ', Nature Medicine, vol. 25, no. 10, pp. 1534-1539 . https://doi.org/10.1038/s41591-019-0593-1
TRACERx Consortium 2019, ' Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse ', Nature Medicine, vol. 25, no. 10, pp. 1534-1539 . https://doi.org/10.1038/s41591-019-0593-1
Approximately 50% of patients with early-stage non-small-cell lung cancer (NSCLC) who undergo surgery with curative intent will relapse within 5 years1,2. Detection of circulating tumor cells (CTCs) at the time of surgery may represent a tool to iden
Autor:
Kristopher K. Frese, Donna M. Graham, Nicholas Hickson, Alexandra Clipson, Crispin J. Miller, Sumitra Mohan, Saba Ferdous, Matthew G Krebs, Alexander J Vickers, Bedirhan Kilerci, Helen Eaton, Caroline Dive, Siobhan Southam, Roopa Kurup, Hannah Frost, Ciara O’Brien, Fiona C Thistlethwaite, Richard Marais, Allan M. Jordan, Mahmood Ayub, Robert Metcalf, Jaseela Chiramel, Louise Carter, Daniel J. White, Emma Dean, Matthew Howell, Sreeja Aruketty, Avinash Gupta, Joanne Dransfield, Ged Brady, Kamrun Nessa, Donal Landers, Claire L. S. Kelly, Shaun Villa, Julie Stevenson, Dominic G. Rothwell, Nigel K Smith, Andrew Hughes, Nadina Tinsley, Natalie Cook, Sakshi Gulati, Andrew L. Wallace
Publikováno v:
Rothwell, D, Ayub, M, Cook, N, Thistlethwaite, F, Carter, L, Dean, E, Smith, N, Villa, S, Dransfield, J, Clipson, A, White, D, Nessa, K, Ferdous, S, Howell, M, Gupta, A, Kilerci, B, Mohan, S, Frese, K, Gulati, S, Miller, C, Jordan, A, Eaton, H, Hickson, N, O'Brien, C, Graham, D, Kelly, C, Aruketty, S, Metcalf, R, Chiramel, J, Tinsley, N, Vickers, AJ, Kurup, R, Frost, H, Stevenson, J, Southam, S, Landers, D, Wallace, A, Marais, R, Hughes, AM, Brady, G, Dive, C & Krebs, M 2019, ' Utility of ctDNA to support patient selection for early phase clinical trials: The TARGET Study ', Nature Medicine, vol. 25, no. 5, pp. 738-743 . https://doi.org/10.1038/s41591-019-0380-z, https://doi.org/10.1038/s41591-019-0380-z
Next-generation sequencing (NGS) of circulating tumor DNA (ctDNA) supports blood-based genomic profiling but is not yet routinely implemented in the setting of a phase I trials clinic. TARGET is a molecular profiling program with the primary aim to m
Autor:
Alicia-Marie Conway, Alexandra Clipson, Francesca Chemi, Simon Pearce, Katarzyna Kamieniecka, Saba Ferdous, Sophie Richardson, Elaine Kilgour, Matthew G. Krebs, Alastair Kerr, Dominic Rothwell, Natalie Cook, Caroline Dive
Publikováno v:
Cancer Research. 82:2808-2808
Cancers of Unknown Primary (CUP) comprise a heterogeneous group of metastatic cancers where the primary site is undetectable. It accounts for 2% of all new UK cancer diagnoses and is the 6th leading cause of cancer death. Favourable subsets of CUP ex
Autor:
Saba Ferdous, Dhruva Biswas, Deborah J. Burt, Barbara Mesquita, Fiona H Blackhall, Gareth A. Wilson, Sophia Ward, Marek Dynowski, Crispin J. Miller, Jackie Pierce, Simon P. Pearce, Mariam Jamal-Hanjani, Yvonne Summers, Selvaraju Veeriah, Ged Brady, Fabio Gomes, Daniel Slane-Tan, Nicolai Juul Birkbak, Maise Al Bakir, Allan Hackshaw, Cong Zhou, David Moore, Philip A.J. Crosbie, Jonathan Tugwood, Chang Sik Kim, Caroline Dive, R. Shah, Charles Swanton, Francesca Chemi, Nicholas McGranahan, Crispin T. Hiley, Sakshi Gulati, Christopher Abbosh, Dominic G. Rothwell
Publikováno v:
Nature Medicine. 26:1147-1147
Publikováno v:
International Journal of Computer Applications. 67:1-5
Natural products including phytochemicals have been recently proposed as tumor suppressors. In this paper, docking study is presented to use these phytochemicals for their prospective role in cancers including breast and prostate cancer. The most com
Publikováno v:
Drug Design, Development and Therapy
Drug Design, Development and Therapy, Dove Medical Press, 2014, pp.187. ⟨10.2147/dddt.s72794⟩
Drug Design, Development and Therapy, Dove Medical Press, 2014, pp.187. ⟨10.2147/dddt.s72794⟩
Muhammad Usman Mirza,1 A Hammad Mirza,2 Noor-Ul-Huda Ghori,3 Saba Ferdous4 1Centre for Research in Molecular Medicine, The University of Lahore, Lahore, Pakistan; 2Department of Bioscience, COMSATS Institute of Information Technology, Sahiwal, Pakist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4741162008d0f44307965a8348b40e
https://lirias.kuleuven.be/handle/123456789/588616
https://lirias.kuleuven.be/handle/123456789/588616
Publikováno v:
Computational biology and chemistry. 47
We study the structural basis of APPL and Reptin binding in context with APPL1/APPL2 dimerization.We perform a detailed in silico analysis using the knowledge of APPL1/2 heterodimerization and infer that binding of APPLPH to BAR domain and Reptin is
Publikováno v:
Enzyme Engineering.
Aurora kinase family members are involved in a wide variety of cell cycle events including centrosome separation, cytokinesis, kinetochore formation, spindle assembly, chromosomal segregation and microtubule dynamics. Typically, dysfunction of Aurora