Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Saba Aid"'
Autor:
Manuel Sanchez-Alavez, Martin Holzenberger, Saba Aid, Jean-Christophe François, Tiffany Lien, Ruben Gonzalez-Rivera, Tamas Bartfai, Rigo Cintron-Colon, Simone Mori, William Nguyen, Bruno Conti
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(36)
When food resources are scarce, endothermic animals can lower core body temperature (Tb). This phenomenon is believed to be part of an adaptive mechanism that may have evolved to conserve energy until more food becomes available. Here, we found in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8491ad25ab84e2d8aaab2afb644679e1
https://pubmed.ncbi.nlm.nih.gov/28827363
https://pubmed.ncbi.nlm.nih.gov/28827363
Autor:
Francine Côté, Racha Fayad, Jie Xu, Jean-Christophe François, Patrick C. Even, Philippe Lacube, Martin Holzenberger, Zayna Chaker, Saba Aid
Publikováno v:
Endocrinology
Endocrinology, Endocrine Society, 2017, 158 (7), pp.2269-2283. ⟨10.1210/en.2017-00261⟩
Endocrinology, 2017, 158 (7), pp.2269-2283. ⟨10.1210/en.2017-00261⟩
Endocrinology, Endocrine Society, 2017, 158 (7), pp.2269-2283. ⟨10.1210/en.2017-00261⟩
Endocrinology, 2017, 158 (7), pp.2269-2283. ⟨10.1210/en.2017-00261⟩
International audience; Growth hormone (GH) and insulinlike growth factor (IGF) promote aging and age-related pathologies. Inhibiting this pathway by targeting IGF receptor (IGF-1R) is a promising strategy to extend life span, alleviate age-related d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3a1d537edb04d44b909fd5e39bfdf4
https://hal.archives-ouvertes.fr/hal-02346947
https://hal.archives-ouvertes.fr/hal-02346947
Autor:
Dylla Ait Ahmed, Martin Holzenberger, Saba Aid, Cira Dansokho, Vanessa Calle, Pierre Aucouturier, Cécile Toly-Ndour, Eliane Piaggio, Guillaume Dorothée, Thomas Chaigneau, Nicolas Cagnard
Publikováno v:
Alzheimer's & Dementia. 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::449bc540347ebbb50cfad3c36f98ac9b
https://doi.org/10.1016/j.jalz.2016.06.432
https://doi.org/10.1016/j.jalz.2016.06.432
Autor:
R. Scott Turner, Luca Caracciolo, Mark P. Mattson, S. Sakura Minami, Takako Niikura, Sang-Ho Choi, Saba Aid, Yasuji Matsuoka, Francesca Bosetti
Publikováno v:
Journal of Neurochemistry. 124:59-68
Several epidemiological and preclinical studies suggest that non-steroidal anti-inflammatory drugs (NSAIDs), which inhibit cyclooxygenase (COX), reduce the risk of Alzheimer's disease (AD) and can lower β-amyloid (Aβ) production and inhibit neuroin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc33ef876ae5a6fd5e7378417e59c0f
https://doi.org/10.1111/jnc.12059
https://doi.org/10.1111/jnc.12059
Publikováno v:
Journal of Neurochemistry. 120:292-301
Like macrophages, microglia are functionally polarized into different phenotypic activation states, referred as classical and alternative. The balance of the two phenotypes may be critical to ensure proper brain homeostasis, and may be altered in bra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86639840e1c9822868745f726dcda27b
https://doi.org/10.1111/j.1471-4159.2011.07572.x
https://doi.org/10.1111/j.1471-4159.2011.07572.x
Publikováno v:
The Pharmacogenomics Journal. 10:448-457
Peripheral leukocyte recruitment in neuroinflammatory conditions can exacerbate brain tissue damage by releasing cytotoxic mediators and by increasing vascular permeability. Cyclooxygenase (COX)-derived prostaglandins promote the migration of several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c108a7c9286afc8dc5698e1deae83d
https://doi.org/10.1038/tpj.2009.68
https://doi.org/10.1038/tpj.2009.68
Autor:
Gary A. Rosenberg, Afonso C. Silva, Sang-Ho Choi, Eduardo Candelario-Jalil, Saba Aid, Francesca Bosetti
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 30:370-380
Cyclooxygenases (COX) -1 and -2 are key regulators of innate immune responses. We recently demonstrated that the expression of proinflammatory cytokines and chemokines is reduced in COX-1 null (−/−), and increased in COX-2−/− mice compared wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4530982cd58ce09309fb1c4f0dba93
https://doi.org/10.1038/jcbfm.2009.223
https://doi.org/10.1038/jcbfm.2009.223
Publikováno v:
The Pharmacogenomics Journal. 9:116-126
Neuroinflammation plays a role in the progression of several neurodegenerative disorders. We used a lipopolysaccharide (LPS) model of neuroinflammation to characterize the gene expression changes underlying the inflammatory and behavioral effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d87e32cbc82435b49279a381a6459d2
https://doi.org/10.1038/tpj.2008.15
https://doi.org/10.1038/tpj.2008.15
Autor:
Francesca Bosetti, Saba Aid
Publikováno v:
Brain Research Bulletin. 73:108-113
Brain aging is associated with inflammatory changes. However, data on how the brain arachidonic acid (AA) metabolism is altered as a function of age are limited and discrepant. AA is released from membrane phospholipids by phospholipase A(2) (PLA(2))
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1bb66e28aaee7b5fde41304f058debe
https://doi.org/10.1016/j.brainresbull.2007.02.015
https://doi.org/10.1016/j.brainresbull.2007.02.015
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(33)
Alzheimer9s disease (AD) is a frequent and irreversible age-related neurodegeneration without efficient treatment. Experimental AD in mice responds positively to decreased insulin-like growth factor I (IGF-I) signaling, a pathway also implicated in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce147b931c2bf5c8ac0c5a9410d92e58
https://pubmed.ncbi.nlm.nih.gov/26290229
https://pubmed.ncbi.nlm.nih.gov/26290229