Cytoplasmic production of Fabs in chemically defined media in fed-batch fermentation.

Autor: Castillo-Corujo A; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland., Saaranen MJ; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland., Ruddock LW; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland. Electronic address: lloyd.ruddock@oulu.fi.

Publikováno v: Protein expression and purification [Protein Expr Purif] 2024 Mar; Vol. 215, pp. 106404. Date of Electronic Publication: 2023 Nov 16.

Mutation in protein disulfide isomerase A3 causes neurodevelopmental defects by disturbing endoplasmic reticulum proteostasis.

Autor: Bilches Medinas D; Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile.; FONDAP Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile., Malik S; Human Genetics Program, Department of Zoology, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan., Yıldız-Bölükbaşı E; Department of Molecular Biology and Genetics, Boğaziçi University, Istanbul, Turkey., Borgonovo J; Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile.; FONDAP Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.; Program of Integrative Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile., Saaranen MJ; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland., Urra H; Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile.; FONDAP Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile., Pulgar E; Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile.; Program of Integrative Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile., Afzal M; Human Genetics Program, Department of Zoology, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan., Contreras D; Laboratory of Neuroscience, Department of Biology, Faculty of Chemistry and Biology, University of Santiago de Chile, Santiago, Chile., Wright MT; Department of Chemistry, Vanderbilt University, Nashville, TN, USA., Bodaleo F; FONDAP Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.; Laboratory of Cell and Neuronal Dynamics (CENEDYN), Department of Biology, Faculty of Sciences, University of Chile, Santiago, Chile., Quiroz G; Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile.; FONDAP Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile., Rozas P; Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile.; FONDAP Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile., Mumtaz S; Human Genetics Program, Department of Zoology, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.; Department of Biological Sciences, National University of Medical Sciences, Rawalpindi, Pakistan., Díaz R; Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile.; FONDAP Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile., Rozas C; Laboratory of Neuroscience, Department of Biology, Faculty of Chemistry and Biology, University of Santiago de Chile, Santiago, Chile., Cabral-Miranda F; Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile.; FONDAP Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.; Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Piña R; Laboratory of Neuroscience, Department of Biology, Faculty of Chemistry and Biology, University of Santiago de Chile, Santiago, Chile., Valenzuela V; Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile.; FONDAP Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile., Uyan O; Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA., Reardon C; Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA.; Horae Gene Therapy Center, University of Massachusetts Medical School, Worcester, MA, USA., Woehlbier U; Center for Integrative Biology, Faculty of Science, Universidad Mayor, Santiago, Chile., Brown RH; Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA., Sena-Esteves M; Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA.; Horae Gene Therapy Center, University of Massachusetts Medical School, Worcester, MA, USA., Gonzalez-Billault C; FONDAP Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.; Laboratory of Cell and Neuronal Dynamics (CENEDYN), Department of Biology, Faculty of Sciences, University of Chile, Santiago, Chile.; Buck Institute for Research on Aging, Novato, CA, USA., Morales B; Laboratory of Neuroscience, Department of Biology, Faculty of Chemistry and Biology, University of Santiago de Chile, Santiago, Chile., Plate L; Department of Chemistry, Vanderbilt University, Nashville, TN, USA.; Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA., Ruddock LW; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland., Concha ML; Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile.; FONDAP Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.; Program of Integrative Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile., Hetz C; Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile.; FONDAP Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.; Buck Institute for Research on Aging, Novato, CA, USA., Tolun A; Department of Molecular Biology and Genetics, Boğaziçi University, Istanbul, Turkey.; Department of Molecular Biology and Genetics, Istanbul Technical University, Istanbul, Turkey.

Publikováno v: The EMBO journal [EMBO J] 2022 Dec 17; Vol. 41 (2), pp. e105531. Date of Electronic Publication: 2021 Dec 14.

High-resolution Crystal Structure of Human pERp1, A Saposin-like Protein Involved in IgA, IgM and Integrin Maturation in the Endoplasmic Reticulum.

Autor: Sowa ST; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Aapistie 7, 90220 Oulu, Finland; Biocenter Oulu, Aapistie 5, 90220 Oulu, Finland. Electronic address: sven.sowa@oulu.fi., Moilanen A; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Aapistie 7, 90220 Oulu, Finland. Electronic address: antti.moilanen@oulu.fi., Biterova E; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Aapistie 7, 90220 Oulu, Finland., Saaranen MJ; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Aapistie 7, 90220 Oulu, Finland. Electronic address: mirva.saaranen@oulu.fi., Lehtiö L; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Aapistie 7, 90220 Oulu, Finland; Biocenter Oulu, Aapistie 5, 90220 Oulu, Finland. Electronic address: lari.lehtio@oulu.fi., Ruddock LW; Faculty of Biochemistry and Molecular Medicine, University of Oulu, Aapistie 7, 90220 Oulu, Finland. Electronic address: lloyd.ruddock@oulu.fi.

Publikováno v: Journal of molecular biology [J Mol Biol] 2021 Mar 05; Vol. 433 (5), pp. 166826. Date of Electronic Publication: 2021 Jan 14.

Applications of catalyzed cytoplasmic disulfide bond formation.

Autor: Saaranen MJ; Faculty of Biochemistry and Molecular Medicine and Biocenter Oulu, University of Oulu, Aapistie 7, 90220 Oulu, Finland., Ruddock LW; Faculty of Biochemistry and Molecular Medicine and Biocenter Oulu, University of Oulu, Aapistie 7, 90220 Oulu, Finland.

Publikováno v: Biochemical Society transactions [Biochem Soc Trans] 2019 Oct 31; Vol. 47 (5), pp. 1223-1231.

Biophysical and structural studies of fibulin-2.

Autor: Sohail, Anil A.¹ (AUTHOR), Koski, M. Kristian^1,2 (AUTHOR), Ruddock, Lloyd W.^1,2 (AUTHOR) lloyd.ruddock@oulu.fi

Publikováno v: Scientific Reports. 7/2/2024, Vol. 14 Issue 1, p1-11. 11p.