Effects of Levosimendan on Cardiac Gene Expression Profile and Post-Infarct Cardiac Remodelling in Diabetic Goto-Kakizaki Rats

Autor: Jarkko Lakkisto, Erik Vahtola, Marjut Louhelainen, Petri Kaheinen, Ilkka Tikkanen, Saara Merasto, Markus Storvik, Jouko Levijoki, Päivi Lakkisto, Eero Mervaala

Publikováno v: Basic & Clinical Pharmacology & Toxicology. 109:387-397

The calcium sensitizer levosimendan has shown beneficial effects on cardiac remodelling in spontaneously diabetic Goto-Kakizaki (GK) rats 12 weeks after experimental myocardial infarction (MI). However, the short-term effects and the cellular mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e42550c6c923a9a219c9cd44d3c6dc4e
https://doi.org/10.1111/j.1742-7843.2011.00743.x

Levosimendan improves cardiac function and survival in rats with angiotensin II-induced hypertensive heart failure

Autor: Friedrich C. Luft, Jouko Levijoki, Petri Kaheinen, Agnieszka Biala, Essi Martonen, Saara Merasto, Dominik N. Müller, Marjut Louhelainen, Piet Finckenberg, Eero Mervaala

Publikováno v: Hypertension Research. 33:1004-1011

Calcium-sensitizing agents improve cardiac function in acute heart failure; however, their long-term effects on cardiovascular mortality are unknown. We tested the hypothesis that levosimendan, an inodilator that acts through calcium sensitization, o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754e2970bafa1692ffe3ecb05beaf263
https://doi.org/10.1038/hr.2010.123

Metabolomics in Angiotensin II-Induced Cardiac Hypertrophy

Autor: Juha Lempiäinen, Ove Eriksson, Matej Orešič, Marjut Louhelainen, Friedrich C. Luft, Essi Martonen, Risto Lapatto, Agnieszka Biala, Dominik N. Müller, Ismo Mattila, Petri Kaheinen, Eero Mervaala, Piet Finckenberg, Saara Merasto

Publikováno v: Mervaala, E, Biala, A, Merasto, S, Lempiäinen, J, Mattila, I, Martonen, E, Eriksson, O, Louhelainen, M, Finckenberg, P, Kaheinen, P, Muller, D N, Luft, F C, Lapatto, R & Orešič, M 2010, ' Metabolomics in Angiotensin II-Induced Cardiac Hypertrophy ', Hypertension, vol. 55, pp. 508-515 . https://doi.org/10.1161/HYPERTENSIONAHA.109.145490

Angiotensin II (Ang II) induces mitochondrial dysfunction. We tested whether Ang II alters the “metabolomic” profile. We harvested hearts from 8-week-old double transgenic rats harboring human renin and angiotensinogen genes (dTGRs) and controls

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca7417588ee61c8eb395d4a3f8375e63
https://doi.org/10.1161/hypertensionaha.109.145490

Oral levosimendan prevents postinfarct heart failure and cardiac remodeling in diabetic Goto-Kakizaki rats

Autor: Hanna Leskinen, Ville Kytö, Erik Vahtola, Piet Finckenberg, Petri Kaheinen, Marjut Louhelainen, Hanna Forsten, Jouko Levijoki, Eero Mervaala, Ilkka Tikkanen, Saara Merasto

Publikováno v: Journal of Hypertension. 27:2094-2107

Background Diabetes increases the risk for fatal myocardial infarction and development of heart failure. Levosimendan, an inodilator acting both via calcium sensitization and opening of ATP-dependent potassium channels, is used intravenously for acut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7fcb54a983b78e41ee459d20b79c504
https://doi.org/10.1097/hjh.0b013e32832f0ce4

Lipoic acid supplementation prevents cyclosporine-induced hypertension and nephrotoxicity in spontaneously hypertensive rats

Autor: Marjut Louhelainen, Risto Lapatto, Piet Finckenberg, Eero Mervaala, Saara Merasto, Zhongjian Cheng

Publikováno v: Journal of Hypertension. 24:947-956

BACKGROUND Cyclosporine (CsA) has significantly improved long-term survival after organ transplantations. Hypertension and nephrotoxicity are common side effects during CsA treatment and are aggravated by high salt intake. OBJECTIVE To examine whethe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dee05f862ad9f444b04cf39874d28b5
https://doi.org/10.1097/01.hjh.0000222766.37971.9f