Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Saara Lehmusvaara"'
Autor:
Juha Saarikettu, Saara Lehmusvaara, Marko Pesu, Ilkka Junttila, Juha Partanen, Petra Sipilä, Matti Poutanen, Jie Yang, Teemu Haikarainen, Olli Silvennoinen
Publikováno v:
FASEB BioAdvances, Vol 5, Iss 5, Pp 183-198 (2023)
Abstract Snd1 is an evolutionarily conserved RNA‐binding protein implicated in several regulatory processes in gene expression including activation of transcription, mRNA splicing, and microRNA decay. Here, we have investigated the outcome of Snd1
Externí odkaz:
https://doaj.org/article/16f18b224da54a86aa8f9e82d02f1857
Publikováno v:
BioTechniques, Vol 40, Iss 5, Pp 573-576 (2006)
Externí odkaz:
https://doaj.org/article/d37a346410bf4a639a5fbb93bcc7f703
Autor:
Saara Lehmusvaara, Teemu Haikarainen, Juha Saarikettu, Guillermo Martinez Nieto, Olli Silvennoinen
Publikováno v:
Cancers; Volume 14; Issue 13; Pages: 3100
SND1 is an RNA-binding protein overexpressed in large variety of cancers. SND1 has been proposed to enhance stress tolerance in cancer cells, but the molecular mechanisms are still poorly understood. We analyzed the expression of 372 miRNAs in the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc0f8cd0fadc99f6de229f7846e443b
https://doi.org/10.3390/cancers14133100
https://doi.org/10.3390/cancers14133100
Autor:
Alfonso Urbanucci, Timo Erkkilä, Janne Seppälä, Saara Lehmusvaara, Harri Lähdesmäki, Vilppu J. Tuominen, Antti Kaipia, Tapio Visakorpi, Paula Kujala, Antti Larjo, Jorma Isola, Kati K. Waltering, Teuvo L.J. Tammela
Publikováno v:
The Journal of Pathology. 227:336-345
Endocrine therapy by castration or anti-androgens is the gold standard treatment for advanced prostate cancer. Although it has been used for decades, the molecular consequences of androgen deprivation are incompletely known and biomarkers of its resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::766394b1fb7c61c778b6fd166c73aba9
https://doi.org/10.1002/path.4027
https://doi.org/10.1002/path.4027
Autor:
Saara Lehmusvaara, T. Visakorpi, Pekka Ruusuvuori, Harri Lähdesmäki, Timo Erkkilä, Ilya Shmulevich
Publikováno v:
Bioinformatics
Motivation: Tissue heterogeneity, arising from multiple cell types, is a major confounding factor in experiments that focus on studying cell types, e.g. their expression profiles, in isolation. Although sample heterogeneity can be addressed by manual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff0e2c5995451e6e9bed874e14e9b36
http://europepmc.org/articles/PMC2951082
http://europepmc.org/articles/PMC2951082
Autor:
Hannu Oja, Tapio Visakorpi, Teuvo L.J. Tammela, Saara Lehmusvaara, Hazel Bracken, Sanni E. Jalava, Jarkko Isotalo, Hanna E. Rauhala
Publikováno v:
International Journal of Cancer; Vol 127
miRNAs have proven to be key regulators of gene expression and are differentially expressed in various diseases, including cancer. Our aim was to identify epigenetically dysregulated genes in prostate cancer. We performed miRNA expression profiling a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05feeb5b35a631c371f5dfac7229671f
https://doi.org/10.1002/ijc.25162
https://doi.org/10.1002/ijc.25162
Autor:
Janne Seppälä, Harri Lähdesmäki, Saara Lehmusvaara, Timo Erkkilä, Sanni E. Jalava, Tapio Visakorpi, Teuvo L.J. Tammela, Antti Kaipia, Paula Kujala, Alfonso Urbanucci
Publikováno v:
The Prostate. 73(1)
BACKGROUND Although endocrine therapy has been used for decades, its influence on the expression of microRNAs (miRNAs) in clinical tissue specimens has not been analyzed. Moreover, the effects of the TMPRSS2:ERG fusion on the expression of miRNAs in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cd449336d58f3d9aa8468b40f886d76
https://pubmed.ncbi.nlm.nih.gov/22674191
https://pubmed.ncbi.nlm.nih.gov/22674191
Autor:
Saara, Lehmusvaara, Timo, Erkkilä, Alfonso, Urbanucci, Kati, Waltering, Janne, Seppälä, Antti, Larjo, Vilppu J, Tuominen, Jorma, Isola, Paula, Kujala, Harri, Lähdesmäki, Antti, Kaipia, Teuvo Lj, Tammela, Tapio, Visakorpi
Publikováno v:
The Journal of pathology. 227(3)
Endocrine therapy by castration or anti-androgens is the gold standard treatment for advanced prostate cancer. Although it has been used for decades, the molecular consequences of androgen deprivation are incompletely known and biomarkers of its resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b2c61947df655f4d4bb2aacd63a117d1
https://pubmed.ncbi.nlm.nih.gov/22431170
https://pubmed.ncbi.nlm.nih.gov/22431170
Autor:
Jarmo Wahlfors, Outi Rautsi, Ann-Marie Määttä, Riikka Pellinen, Saara Lehmusvaara, Anna Ketola
Publikováno v:
Cancer gene therapy. 15(5)
Cancer suicide gene therapy based on herpes simplex virus type I thymidine kinase (HSV-TK) and ganciclovir (GCV) suffers from the lack of efficacy in clinical use, which is mostly due to low gene-transfer efficiency and absence of bystander effect in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb1082bef7c00457f52a9ac41ba7b07d
https://pubmed.ncbi.nlm.nih.gov/18309353
https://pubmed.ncbi.nlm.nih.gov/18309353
Autor:
Outi Rautsi, Riikka Pellinen, Maarit Sillanpää, Tuula Salonen, Katja Häkkinen, Saara Lehmusvaara, Ilkka Julkunen, Tanja Hakkarainen, Seppo Ylä-Herttuala, Jarmo Wahlfors, Ari Hinkkanen, Elisa Vähäkangas, Sami Heikkinen
Publikováno v:
The journal of gene medicine. 9(2)
Background Type I interferon (IFN-α/β) response is one of the major host defence mechanisms against viruses. Some recent reports suggest that IFNs may interfere with the efficacy of both non-viral and virus-vector-mediated therapeutic gene transfer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b2ecdc8acc3d54b9c3c4e04c41e4706
https://pubmed.ncbi.nlm.nih.gov/17191255
https://pubmed.ncbi.nlm.nih.gov/17191255