Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Saara Kaviany"'
Publikováno v:
Children, Vol 5, Iss 11, p 145 (2018)
Prior to the 1950s, survival from Wilms tumor (WT) was less than 10%. Today, a child diagnosed with WT has a greater than 90% chance of survival. These gains in survival rates from WT are attributed largely to improvements in multimodal therapy: Enha
Externí odkaz:
https://doaj.org/article/783f95f5e5ea4f12a284e1227d7963ae
Autor:
Saara Kaviany, Todd Bartkowiak, Daniel E. Dulek, Yasmin W. Khan, Madeline J. Hayes, Samuel G. Schaefer, Xiang Ye, Debolanle O. Dahunsi, James A. Connelly, Jonathan M. Irish, Jeffrey C. Rathmell
Publikováno v:
ImmunoHorizons. 6:447-464
Patients with STAT1 gain-of-function (GOF) pathogenic variants have enhanced or prolonged STAT1 phosphorylation following cytokine stimulation and exhibit increased yet heterogeneous susceptibility to infections, autoimmunity, and cancer. Although di
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Jonathan M. Irish, Daniel E. Dulek, Madeline Hayes, James A. Connelly, Yasmin W. Khan, Samuel Schaefer, Todd Bartkowiak, Jeffrey C. Rathmell, Debolanle O. Dahunsi, Saara Kaviany
Patients with Signal Transducer and Activator of Transcription 1 (STAT1) gain-of-function (GOF) pathogenic variants exhibit susceptibility to infections, autoimmunity, and cancer due to enhanced or prolonged STAT1 phosphorylation following cytokine s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07921320e4ec858dc89f16f652df7c68
https://doi.org/10.1101/2021.11.10.468135
https://doi.org/10.1101/2021.11.10.468135
Autor:
Carrie L. Kitko, Saara Kaviany
Publikováno v:
Curr Opin Hematol
PURPOSE OF REVIEW: Graft-versus-host disease (GVHD) following hematopoietic cell transplant (HCT) has a significant impact on morbidity and mortality among recipients. Predicting the long-term outcomes at the time of diagnosis of GVHD or even after r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d38b2399949d2bca3e0d55a46486994f
https://europepmc.org/articles/PMC10189358/
https://europepmc.org/articles/PMC10189358/
Autor:
Nicholas J. Gloude, Yiouli P. Ktena, Michelle Hudspeth, Hemalatha G. Rangarajan, Paul L. Martin, Birgitta Versluys, Megan E. Sampson, Hesham Eissa, David A. Jacobsohn, Persis Amrolia, Heather J. Symons, Katherine M. Somers, Amy K. Keating, Shanti Ramachandran, Neel S. Bhatt, Kimberly A. Kasow, Erika S. Goeckerman, W. Scott Goebel, Akshay Sharma, Jodi L. Skiles, Marc Bierings, Nancy A. Kernan, Adam Gassas, Ibrahim Ahmed, Claire Brisset, Swati Naik, Heather B. Allewelt, Alice Bertaina, Peter J. Shaw, Ying Li, Joshua J. Bies, Russell J. Brooke, Jean Hugues Dalle, Richard H. Ho, Kristie N. Ramos, Katherine Harris, Toshihiro Onishi, Philip A. Roehrs, Alberto Olaya-Vargas, Allison Uber, Ann Dahlberg, Jennifer E. Brondon, Marie de Tersant, Emmanuel Katsanis, Colette R. Lauhan, Brandon M. Triplett, Sujuan Huang, Saara Kaviany, Jeffrey S. Huo, Mony Fahd, Cheng Cheng, Kasiani C. Myers, Mohamed Radhi, Gerardo López-Hernandez
Publikováno v:
Bone Marrow Transplant
Long-term outcomes after allogeneic hematopoietic cell transplantation (HCT) for therapy-related myeloid neoplasms (tMNs) are dismal. There are few multicenter studies defining prognostic factors in pediatric patients with tMNs. We have accumulated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d111cfc3b268a2fd401b6a450020d9fb
https://europepmc.org/articles/PMC9260859/
https://europepmc.org/articles/PMC9260859/
Publikováno v:
Primary and Secondary Immunodeficiency ISBN: 9783030571566
Congenital conditions caused by an absolute or functional deficiency of neutrophils are associated with considerable morbidity and mortality in children and adults. These disorders manifest with various phenotypes, but all contribute to an elevated r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::506ba0aabe38bc3147f6320d219bf670
https://doi.org/10.1007/978-3-030-57157-3_16
https://doi.org/10.1007/978-3-030-57157-3_16
Autor:
Marina Cella, Mary C. Dinauer, Elaine Kulm, Michelle A. Ritter, Jahnavi Aluri, Alicia Bach, Elise M. Rizzi, Christina Bemrich-Stolz, Maleewan Kitcharoensakkul, Magdalena Walkiewicz, Jack J. Bleesing, Yi Shan Lee, James A. Connelly, Amy M. Scurlock, Laura G. Schuettpelz, Marwan Shinawi, Shirley M. Abraham, Saara Kaviany, V. Koneti Rao, Jonathan D. Powell, Jeffrey J. Bednarski, Peggy L. Kendall, Luana Chiquetto Paracatu, Raphaela Goldbach-Mansky, Christopher D. Putnam, Michael T. Harmon, Adriana Almeida de Jesus, Scott W. Canna, Stacie M. Jones, Morgan Similuk, Matthew M. Demczko, Nermina Saucier, Suk See De Ravin, Michael Joyce, Molly P. Keppel, Megan A. Cooper
Publikováno v:
Blood
Inborn errors of immunity (IEI) are a genetically heterogeneous group of disorders with a broad clinical spectrum. Identification of molecular and functional bases of these disorders is important for diagnosis, treatment, and an understanding of the
Autor:
Saara Kaviany, Carrie Kitko, Cesar Rueda, Roshini Abraham, Debra Friedman, Sarah Neumann, Becky Manes, Sara Zarnegar Lumley, James Connelly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc48e31dd1d6640e891e68cd7a04ee58
https://doi.org/10.22541/au.160157459.97405496
https://doi.org/10.22541/au.160157459.97405496
Deep Immune Profiling of Patients with STAT1 Gain-of-Function: Revealing New Mechanisms of Pathology
Autor:
Jim A. Connelly, Jonathan M. Irish, Jeffrey C. Rathmell, Daniel E. Dulek, Todd Bartowiak, Yasmin W. Khan, Saara Kaviany
Publikováno v:
Blood. 138:2067-2067
Background: Patients with heterozygous signal transducer and activator of transcription 1 (STAT1) gain-of-function (GOF) pathogenic variants exhibit an array of clinical phenotypes including susceptibility to multiple infections, autoimmunity, and ca