Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Saadia Khilji"'
Publikováno v:
Journal of Big Data, Vol 9, Iss 1, Pp 1-11 (2022)
Abstract Dynamic changes in epigenetic landscape reflect a critical command of lineage-specific gene expression. In an effort to discern the epigenetic regulatory networks of myogenic differentiation, we have used systematic and integrative approache
Externí odkaz:
https://doaj.org/article/3410a116fa164ccf8291e5ed18141d7c
Publikováno v:
PeerJ, Vol 11, p e15961 (2023)
Histone acetylation and deacetylation affect the patterns of gene expression in cellular differentiation, playing pivotal roles in tissue development and maintenance. For example, the intrinsic histone acetyltransferase activity of transcriptional co
Externí odkaz:
https://doaj.org/article/700ebf24550e465080ef8e0e25a08391
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Stem cells represent a key resource in regenerative medicine, however, there is a critical need for pharmacological modulators to promote efficient conversion of stem cells into a myogenic lineage. We have previously shown that bexarotene, an agonist
Externí odkaz:
https://doaj.org/article/3cf5ebcaf301434b85c6b29b26d98362
Publikováno v:
Epigenetics, Vol 13, Iss 6, Pp 642-654 (2018)
Molecular regulation of stem cell differentiation is exerted through both genetic and epigenetic determinants over distal regulatory or enhancer regions. Understanding the mechanistic action of active or poised enhancers is therefore imperative for c
Externí odkaz:
https://doaj.org/article/7f1da48634634bbaa815e034426c1864
Autor:
Jihang Yu, Wangshu Tu, Andrea Payne, Chris Rudyk, Sarita Cuadros Sanchez, Saadia Khilji, Premkumari Kumarathasan, Sanjeena Subedi, Brittany Haley, Alicia Wong, Catalina Anghel, Yi Wang, Vinita Chauhan
Publikováno v:
International journal of radiation biology. 98(12)
In the past three decades, a large body of data on the effects of exposure to ionizing radiation and the ensuing changes in gene expression has been generated. These data have allowed for an understanding of molecular-level events and shown a level o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c58d0fa9d5c9c6e961a21d6a65906045
https://pubmed.ncbi.nlm.nih.gov/35939063
https://pubmed.ncbi.nlm.nih.gov/35939063
Dynamic changes in epigenetic landscape reflect a critical command of lineage-specific gene expression. In an effort to discern the epigenetic regulatory networks of myogenic differentiation, we have used systematic and integrated approaches to explo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41406fc2a65d989a80af146801c5b270
https://doi.org/10.21203/rs.3.rs-1374891/v1
https://doi.org/10.21203/rs.3.rs-1374891/v1
Autor:
Yiwei Zhang, Hongsheng Liang, Ning Zhao, Jingjing Liu, Dandan Song, Xiaoxing Wang, Haitao Li, Xina Li, Aili Gao, Saadia Khilji, Chen Chen
Publikováno v:
Journal of Cancer
Moxidectin (MOX), a broad-spectrum antiparasitic drug, has been characterized as a potential anti-glioma agent. The main objective of this study was to explore autophagy induced by MOX in glioma U251 and C6 cells, and the deep underlying molecular me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af8a96d436c726769d4f41e83cca7d64
https://pubmed.ncbi.nlm.nih.gov/32913473
https://pubmed.ncbi.nlm.nih.gov/32913473
Publikováno v:
Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
Deciphering the molecular mechanisms underpinning myoblast differentiation is a critical step in developing the best strategy to promote muscle regeneration in patients suffering from muscle-related diseases. We have previously established that a rex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93df084eb0274832c84a19c7f1021d2d
https://pubmed.ncbi.nlm.nih.gov/32555436
https://pubmed.ncbi.nlm.nih.gov/32555436
Publikováno v:
Epigenetics. 13:642-654
Molecular regulation of stem cell differentiation is exerted through both genetic and epigenetic determinants over distal regulatory or enhancer regions. Understanding the mechanistic action of active or poised enhancers is therefore imperative for c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d4fcfd01b87e51e6fe92972224b671c
https://doi.org/10.1080/15592294.2018.1489659
https://doi.org/10.1080/15592294.2018.1489659
Autor:
Ilya Ioshikhes, Katherine Dixon, Jihong Chen, Qiao Li, Munerah Hamed, Alexandre Blais, Saadia Khilji
Publikováno v:
Nucleic Acids Research
While skeletal myogenesis is tightly coordinated by myogenic regulatory factors including MyoD and myogenin, chromatin modifications have emerged as vital mechanisms of myogenic regulation. We have previously established that bexarotene, a clinically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f83c2412378da99237da8a5849533b2
http://europepmc.org/articles/PMC5737385
http://europepmc.org/articles/PMC5737385