Low Frequency Ventilation During Cardiopulmonary Bypass to Protect Postoperative Lung Function in Cardiac Valvular Surgery: The PROTECTION Phase II Randomized Trial

Autor: Chris A. Rogers, Graziella Mazza, Rachel Maishman, Russell Thirard, Jonathan Evans, Samantha de Jesus, Chloe Beard, Gianni Angelini, Ann Millar, Nabil Jarad, Sally Tomkins, James Hillier, M‐Saadeh Suleiman, Raimondo Ascione

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 19 (2024)

Background Cardiac surgery with cardiopulmonary bypass (CPB) triggers pulmonary injury. In this trial we assessed the feasibility, safety, and efficacy of low frequency ventilation (LFV) during CPB in patients undergoing valvular surgery. Methods and

Externí odkaz: https://doaj.org/article/99e7410fc1b04de693b9ba84c3215f73

Determination of Agrin and Related Proteins Levels as a Function of Age in Human Hearts

Autor: Katie L. Skeffington, Ffion P. Jones, M. Saadeh Suleiman, Massimo Caputo, Andrea Brancaccio, Maria Giulia Bigotti

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 9 (2022)

Background:Mature cardiomyocytes are unable to proliferate, preventing the injured adult heart from repairing itself. Studies in rodents have suggested that the extracellular matrix protein agrin promotes cardiomyocyte proliferation in the developing

Externí odkaz: https://doaj.org/article/b0670d8f4aaa4035948512c64ac3c363

Cardioprotection of Immature Heart by Simultaneous Activation of PKA and Epac: A Role for the Mitochondrial Permeability Transition Pore

Autor: Martin John Lewis, Igor Khaliulin, Katie Hall, M. Saadeh Suleiman

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 3, p 1720 (2022)

Metabolic and ionic changes during ischaemia predispose the heart to the damaging effects of reperfusion. Such changes and the resulting injury differ between immature and adult hearts. Therefore, cardioprotective strategies for adults must be tested

Externí odkaz: https://doaj.org/article/7d603c55cec24a48ab847d21ddbd3605

Neuro-autonomic changes induced by remote ischemic preconditioning (RIPC) in healthy young adults: Implications for stress

Autor: Igor Khaliulin, Arnold N. Fleishman, Nadezhda I. Shumeiko, TatyanaV. Korablina, Stanislav A. Petrovskiy, Raimondo Ascione, M.-Saadeh Suleiman

Publikováno v: Neurobiology of Stress, Vol 11, Iss , Pp - (2019)

The mechanisms underlying the protective effects of remote ischemic preconditioning (RIPC) are not presently clear. Recent studies in experimental models suggest the involvement of the autonomic nervous system (ANS) in cardioprotection. The aim of th

Externí odkaz: https://doaj.org/article/937775b85f5b41fbb981c4feebad1a62

Endothelial glycocalyx is damaged in diabetic cardiomyopathy: angiopoietin 1 restores glycocalyx and improves diastolic function in mice

Autor: Yan Qiu, Stanley Buffonge, Raina Ramnath, Sophie Jenner, Sarah Fawaz, Kenton P. Arkill, Chris Neal, Paul Verkade, Stephen J. White, Melanie Hezzell, Andrew H. J. Salmon, M.-Saadeh Suleiman, Gavin I. Welsh, Rebecca R. Foster, Paolo Madeddu, Simon C. Satchell

Publikováno v: Qiu, Y, Buffonge, S, Ramnath, R, Jenner, S, Fawaz, S, Arkill, K P, Neal, C, Verkade, P, White, S J, Hezzell, M, Salmon, A H J, Suleiman, M-S, Welsh, G I, Foster, R R, Madeddu, P & Satchell, S C 2022, ' Endothelial glycocalyx is damaged in diabetic cardiomyopathy : angiopoietin 1 restores glycocalyx and improves diastolic function in mice ', Diabetologia, vol. 65, no. 5, pp. 879–894 . https://doi.org/10.1007/s00125-022-05650-4

Aims/hypothesis Diabetic cardiomyopathy (DCM) is a serious and under-recognised complication of diabetes. The first sign is diastolic dysfunction, which progresses to heart failure. The pathophysiology of DCM is incompletely understood but microcircu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e35df3bb571173658e77d9051b01825
https://doi.org/10.1007/s00125-022-05650-4