Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Saad, Hannan"'
Autor:
Timothy W Church, Parul Tewatia, Saad Hannan, João Antunes, Olivia Eriksson, Trevor G Smart, Jeanette Hellgren Kotaleski, Matthew G Gold
Publikováno v:
eLife, Vol 10 (2021)
Interplay between the second messengers cAMP and Ca2+ is a hallmark of dynamic cellular processes. A common motif is the opposition of the Ca2+-sensitive phosphatase calcineurin and the major cAMP receptor, protein kinase A (PKA). Calcineurin dephosp
Externí odkaz:
https://doaj.org/article/5707d591c8234b0aac60d37cf11079ff
Autor:
Faye McLeod, Alessandro Bossio, Aude Marzo, Lorenza Ciani, Sara Sibilla, Saad Hannan, Gemma A. Wilson, Ernest Palomer, Trevor G. Smart, Alasdair Gibb, Patricia C. Salinas
Publikováno v:
Cell Reports, Vol 23, Iss 4, Pp 1060-1071 (2018)
Summary: The structural and functional plasticity of synapses is critical for learning and memory. Long-term potentiation (LTP) induction promotes spine growth and AMPAR accumulation at excitatory synapses, leading to increased synaptic strength. Glu
Externí odkaz:
https://doaj.org/article/4a86144031c246239e56082deb8a5668
Autor:
Jonathan Zapata, Edoardo Moretto, Saad Hannan, Luca Murru, Anna Longatti, Davide Mazza, Lorena Benedetti, Matteo Fossati, Christopher Heise, Luisa Ponzoni, Pamela Valnegri, Daniela Braida, Mariaelvina Sala, Maura Francolini, Jeffrey Hildebrand, Vera Kalscheuer, Francesca Fanelli, Carlo Sala, Bernhard Bettler, Silvia Bassani, Trevor G. Smart, Maria Passafaro
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Mutations in the gene encoding Shrm4 are associated with epilepsy and intellectual disability. The authors show that Shrm4 interacts with GABABreceptors and regulates tonic inhibition in the hippocampus, and knockdown of Shrm4 in rats leads to anxiet
Externí odkaz:
https://doaj.org/article/4624279b47d64159ad6a26ab96fc80e0
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 1962-1973 (2016)
Here, we uncover a mechanism for regulating the number of active presynaptic GABAB receptors (GABABRs) at nerve terminals, an important determinant of neurotransmitter release. We find that GABABRs gain access to axon terminals by lateral diffusion i
Externí odkaz:
https://doaj.org/article/6e7ea8e27c3e4389aedc64b86c7eeca5
Autor:
Els F. Halff, Saad Hannan, Jaturon Kwanthongdee, Flavie Lesept, Trevor G. Smart, Josef T. Kittler
Publikováno v:
Science Signaling. 15
The trans-synaptic adhesion molecule neuroligin-2 (NL2) is essential for the development and function of inhibitory synapses. NL2 recruits the postsynaptic scaffold protein gephyrin, which, in turn, stabilizes γ-aminobutyric acid type A receptors (G
Autor:
Pollyanna Goh, Regina Trollmann, Marielle Minere, Saad Hannan, Bernt Popp, Charlotte J. Maughan Jones, Aida Helana Binti Affandi, Trevor G. Smart, Dean Nizetic, Gary Warnes
Publikováno v:
The Journal of Neuroscience. 40:5518-5530
GABAA receptors (GABAARs) are profoundly important for controlling neuronal excitability. Spontaneous and familial mutations to these receptors feature prominently in excitability disorders and neurodevelopmental deficits following disruption to GABA
GABAA receptors (GABAARs) are key orchestrators of neuronal activity and several GABAAR variants have been linked to genetic neurodevelopmental disorders (NDDs) and epilepsies. Here, we report two variants (Met263Lys, Leu267Ile) in the predominant GA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c030261dea937b6b0f67418927fbbdbe
https://doi.org/10.1101/2021.12.08.471533
https://doi.org/10.1101/2021.12.08.471533
Autor:
Matthew G. Gold, João Antunes, Trevor G. Smart, Parul Tewatia, Olivia Eriksson, Saad Hannan, Jeanette Hellgren Kotaleski, Timothy W Church
Publikováno v:
eLife, Vol 10 (2021)
eLife, Vol. 10
eLife
eLife, Vol. 10
eLife
Interplay between the second messengers cAMP and Ca2+ is a hallmark of dynamic cellular processes. A common motif is the opposition of the Ca2+-sensitive phosphatase calcineurin and the major cAMP receptor, protein kinase A (PKA). Calcineurin dephosp
Autor:
Trevor G. Smart, Saad Hannan, Jeanette Hellgren Kotaleski, Parul Tewatia, Matthew G. Gold, Olivia Eriksson, João Antunes, Timothy W Church
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a61fe525ed30adbe747333e58f7adc2
https://doi.org/10.7554/elife.68164.sa2
https://doi.org/10.7554/elife.68164.sa2
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