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Akademický článek

ADAR2 deficiency ameliorates non‐alcoholic fatty liver disease and muscle atrophy through modulating serum amyloid A1

Autor: Mei‐Lang Kung, Tai‐Hua Yang, Chia‐Chi Lin, Jia‐Yun Ho, Tzu‐Chi Hung, Chih‐Hsiang Chang, Kuan‐Wen Huang, Chien‐Chin Chen, Yun‐Wen Chen

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 3, Pp 949-962 (2024)

Abstract Background Non‐alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength, which is com

Externí odkaz: https://doaj.org/article/fb556a7924ad44db8252e7b91d13e836

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SAA1 regulated by S1P/S1PR1 promotes the progression of ESCC via β-catenin activation

Autor: Qianqian Li, Maolin Tang, Shisheng Zhao, Junjie Yang, Yuanlin Meng, Chunmei Meng, Ling Ren, Weimin Hu

Publikováno v: Discover Oncology, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Serum amyloid A1 (SAA1), an inflammation-related molecule, is associated with the malignant progression of many tumors. This study aimed to investigate the role of SAA1 in the progression of esophageal squamous cell carcinoma (ESCC) and its

Externí odkaz: https://doaj.org/article/53263015586f4bd39440209e821576c9

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Akademický článek

Major endothelial damage markers identified from hemadsorption filters derived from treated patients with septic shock – endoplasmic reticulum stress and bikunin may play a role

Autor: Robin Kasper, Armando Rodriguez-Alfonso, Ludger Ständker, Sebastian Wiese, E. Marion Schneider

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionIn septic patients the damage of the endothelial barrier is decisive leading to circulatory septic shock with disseminated vascular coagulation, edema and multiorgan failure. Hemadsorption therapy leads to rapid resolution of clinical sym

Externí odkaz: https://doaj.org/article/d2fdf31fd8d04b938a1861898ae6a20c

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Akademický článek

The role of polymorphisms rs12218 of the SAA1 gene, rs1205 of the CRP gene, and rs7574865 of the STAT4 gene in the formation of predisposition to panniculitis in the Russian cohort of patients (pilot study)

Autor: M. Yu. Krylov, O. N. Egorova, N. V. Konovalova, D. A. Varlamov

Publikováno v: Современная ревматология, Vol 16, Iss 4, Pp 21-26 (2022)

Objective: to study the role of SAA1, CRP and STAT4 gene polymorphisms in the development of panniculitis (PN) and their relationship with clinical and laboratory parameters in the Russian cohort of patients.Patients and methods. The study included 7

Externí odkaz: https://doaj.org/article/a44e47d017c54a96a809624334786581

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Akademický článek

The role of serum amyloid A1 in the adipogenic differentiation of human adipose-derived stem cells basing on single-cell RNA sequencing analysis

Autor: Rongmei Qu, Kai He, Yuchao Yang, Tingyu Fan, Bing Sun, Asmat Ullah Khan, Wenhua Huang, Jun Ouyang, Xinghua Pan, Jingxing Dai

Publikováno v: Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-15 (2022)

Abstract Background Adipose-derived stem cells (ASCs) are obtained from a variety of sources in vivo where they present in large quantities. These cells are suitable for use in autologous transplantation and the construction of tissue-engineered adip

Externí odkaz: https://doaj.org/article/9a0dbd0d9d0e4777a1e26c13b45d7d46

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Akademický článek

SAA1 identified as a potential prediction biomarker for metastasis of hepatocellular carcinoma via multi-omics approaches

Autor: Gang Li, Qingrong Shen, Haotian Xu, Ying Zhou, Cuiping Li, Yasi Li, Min He

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

BackgroundMetastasis is the major cause of high recurrence and mortality of hepatocellular carcinoma (HCC). Unfortunately, there are few reports on effective biomarkers of HCC metastasis. Previous studies have reported that SAA1 may be a predictor an

Externí odkaz: https://doaj.org/article/a88fffc6c55b469186024f0f7bf11989

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Case report: Rapid development of amyloid A amyloidosis in temporal arteritis with SAA1.3 allele; An unusual case of intestinal amyloidosis secondary to temporal arteritis

Autor: Shuhei Yoshida, Haruki Matsumoto, Jumpei Temmoku, Norshalena Shakespear, Yuichiro Kiko, Kentaro Kikuchi, Yuya Sumichika, Kenji Saito, Yuya Fujita, Naoki Matsuoka, Tomoyuki Asano, Shuzo Sato, Eiji Suzuki, Hiroshi Watanabe, Hiromasa Ohira, Kiyoshi Migita

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Temporal arteritis (TA) is a large-vessel vasculitis mostly seen in older patients. Amyloid A (AA) amyloidosis secondary to a chronic inflammation induces multiple organ dysfunctions, including a dysfunction of the gastrointestinal tract. Herein, we

Externí odkaz: https://doaj.org/article/0004119ced7f416d84ae58cd0693959f

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Akademický článek

Relationship of genetic polymorphism of the acute phase marker of inflammation rs12218 of the SAA1 gene with clinical phenotypes of juvenile idiopathic arthritis

Autor: M. Yu. Krylov, E. S. Fedorov, S. O. Salugina

Publikováno v: Современная ревматология, Vol 15, Iss 2, Pp 23-28 (2021)

Objective: to test the hypothesis of a possible relationship between the rs12218 polymorphism of the SAA1 gene and a predisposition to different clinical phenotypes of juvenile idiopathic arthritis (JIA).Patients and methods. Genetic typing of rs1221

Externí odkaz: https://doaj.org/article/13f1ffd11cc24a45846bd67562b3ec8b

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