Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Saïd Kourrich"'
Autor:
Khadija Tarmoun, Véronik Lachance, Victoria Le Corvec, Sara-Maude Bélanger, Guillaume Beaucaire, Saïd Kourrich
Publikováno v:
Brain Sciences, Vol 14, Iss 9, p 881 (2024)
Sigma-1R (S1R) is a ubiquitously distributed protein highly expressed in the brain and liver. It acts as a ligand-inducible chaperone protein localized at the endoplasmic reticulum. S1R participates in several signaling pathways that oversee diverse
Externí odkaz:
https://doaj.org/article/52275046864f4a73b1d77159436ea7db
Autor:
Véronik Lachance, Sara-Maude Bélanger, Célia Hay, Victoria Le Corvec, Vina Banouvong, Mathieu Lapalme, Khadija Tarmoun, Guillaume Beaucaire, Marc P. Lussier, Saïd Kourrich
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 1971 (2023)
For the past several years, fundamental research on Sigma-1R (S1R) protein has unveiled its necessity for maintaining proper cellular homeostasis through modulation of calcium and lipid exchange between the endoplasmic reticulum (ER) and mitochondria
Externí odkaz:
https://doaj.org/article/62299f1355b44625911f93ebee760ecc
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
The consequence of repeated cocaine exposure and prolonged abstinence on glutamate receptor expression in the nucleus accumbens has been extensively studied. However, the early effects of cocaine on NMDAR signaling remain unknown. NMDAR signaling dep
Externí odkaz:
https://doaj.org/article/4e7ea845737041a98987d5f87133bd45
Autor:
Olivier Soriani, Saïd Kourrich
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
The sigma-1 receptor (σ1R) is an endoplasmic reticulum (ER)-resident chaperone protein that acts like an inter-organelle signaling modulator. Among its several functions such as ER lipid metabolisms/transports and indirect regulation of genes transc
Externí odkaz:
https://doaj.org/article/4d906433d2274522b1d42688b2c1959f
Autor:
Valérie C. Cabana, Antoine Y. Bouchard, Audrey M. Sénécal, Kim Ghilarducci, Saïd Kourrich, Laurent Cappadocia, Marc P. Lussier
Publikováno v:
Cells, Vol 10, Iss 11, p 3063 (2021)
Developmental and epileptic encephalopathies (DEE) are rare and serious neurological disorders characterized by severe epilepsy with refractory seizures and a significant developmental delay. Recently, DEE73 was linked to genetic alterations of the R
Externí odkaz:
https://doaj.org/article/19041a9cefa4484d8aa32a40fe48c868
Publikováno v:
Neural Plasticity, Vol 2008 (2008)
The entorhinal cortex receives a large projection from the piriform cortex, and synaptic plasticity in this pathway may affect olfactory processing. In vitro whole cell recordings have been used here to investigate postsynaptic signalling mechanisms
Externí odkaz:
https://doaj.org/article/38049944a7994b4084db466f0b0970f4
Autor:
Pin, Xu, Kazuhiro, Shimomura, Changhoon, Lee, Xiaofei, Gao, Eleanor H, Simpson, Guocun, Huang, Chryshanthi M, Joseph, Vivek, Kumar, Woo-Ping, Ge, Karen S, Pawlowski, Mitchell D, Frye, Saïd, Kourrich, Eric R, Kandel, Joseph S, Takahashi
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(31)
Although a wide variety of genetic tools has been developed to study learning and memory, the molecular basis of memory encoding remains incompletely understood. Here, we undertook an unbiased approach to identify novel genes critical for memory enco
Autor:
Audrey M Sénécal, Antoine Y Bouchard, Laurent Cappadocia, Kim Ghilarducci, Valérie C. Cabana, Marc P. Lussier, Saïd Kourrich
Publikováno v:
Cells
Volume 10
Issue 11
Cells, Vol 10, Iss 3063, p 3063 (2021)
Volume 10
Issue 11
Cells, Vol 10, Iss 3063, p 3063 (2021)
Developmental and epileptic encephalopathies (DEE) are rare and serious neurological disorders characterized by severe epilepsy with refractory seizures and a significant developmental delay. Recently, DEE73 was linked to genetic alterations of the R
Publikováno v:
Cell Host & Microbe. 30:1615-1629.e5
Gut-microbiota membership is associated with diverse neuropsychological outcomes, including substance use disorders (SUDs). Here, we use mice colonized with Citrobacter rodentium or the human γ-Proteobacteria commensal Escherichia coli HS as a model
Autor:
Masaya Yanagi, Wei Li, Carol A. Tamminga, Daniel J. Scott, Saïd Kourrich, Amir Segev, Shari G. Birnbaum, Chunfeng Tan, Jacob M. Lister, Sarah Southcott
Publikováno v:
Molecular psychiatry
Recent findings from in vivo-imaging and human post-mortem tissue studies in schizophrenic psychosis (SzP), have demonstrated functional and molecular changes in hippocampal subfields that can be associated with hippocampal hyperexcitability. In this