Biological fractionation of lithium isotopes by cellular Na+/H+ exchangers unravels fundamental transport mechanisms

Autor: Mallorie Poet, Nathalie Vigier, Yann Bouret, Gisèle Jarretou, Romain Gautier, Saïd Bendahhou, Vincent Balter, Maryline Montanes, Fanny Thibon, Laurent Counillon

Publikováno v: iScience, Vol 26, Iss 6, Pp 106887- (2023)

Summary: Lithium (Li) has a wide range of uses in science, medicine, and industry, but its isotopy is underexplored, except in nuclear science and in geoscience. 6Li and 7Li isotopic ratio exhibits the second largest variation on earth’s surface an

Externí odkaz: https://doaj.org/article/b084bdf0bb44456dabe7e8a13beaf1c6

Unexpected Gating Behaviour of an Engineered Potassium Channel Kir

Autor: Charline Fagnen, Ludovic Bannwarth, Dania Zuniga, Iman Oubella, Rita De Zorzi, Eric Forest, Rosa Scala, Samuel Guilbault, Saïd Bendahhou, David Perahia, Catherine Vénien-Bryan

Publikováno v: Frontiers in Molecular Biosciences, Vol 8 (2021)

In this study, we investigated the dynamics and functional characteristics of the KirBac3.1 S129R, a mutated bacterial potassium channel for which the inner pore-lining helix (TM2) was engineered so that the bundle crossing is trapped in an open conf

Externí odkaz: https://doaj.org/article/ef606afc0a8f4ef69edb9105d4e9fe2c

Biological fractionation of lithium isotopes by cellular Na+/H+ exchangers unravels fundamental transport mechanisms

Autor: Mallorie Poet, Nathalie Vigier, Yann Bouret, Gisèle Jarretou, Saïd Bendahhou, Maryline Montanes, Fanny Thibon, Laurent Counillon

SUMMARYLithium (Li) has a wide range of uses in science, medicine and industry but its isotopy is underexplored, except in nuclear science and in geoscience. 6Li and 7Li isotopic ratio exhibits the second largest variation on Earth’s surface and co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4803f96d994df5f35dd14bd53af47c5f
https://doi.org/10.1101/2022.10.06.510772

Integrative Study of the Structural and Dynamical Properties of a KirBac3.1 Mutant: Functional Implication of a Highly Conserved Tryptophan in the Transmembrane Domain

Autor: Charline Fagnen, Ludovic Bannwarth, Iman Oubella, Dania Zuniga, Ahmed Haouz, Eric Forest, Rosa Scala, Saïd Bendahhou, Rita De Zorzi, David Perahia, Catherine Vénien-Bryan

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2022, 23 (1), pp.335. ⟨10.3390/ijms23010335⟩
International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 335
International Journal of Molecular Sciences, Vol 23, Iss 335, p 335 (2022)

International audience; ATP-sensitive potassium (K-ATP) channels are ubiquitously expressed on the plasma membrane of cells in several organs, including the heart, pancreas, and brain, and they govern a wide range of physiological processes. In pancr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82001f38cf719f7fca92752db1d8fbab
https://hal.sorbonne-universite.fr/hal-03529811/document

Cross Pharmacological, Biochemical and Computational Studies of a Human Kv3.1b Inhibitor from

Autor: Sonia, Maatoug, Amani, Cheikh, Oussema, Khamessi, Hager, Tabka, Zied, Landoulsi, Jean-Marie, Guigonis, Sylvie, Diochot, Saïd, Bendahhou, Rym, Benkhalifa

Publikováno v: International Journal of Molecular Sciences

The voltage-gated K+ channels Kv3.1 display fast activation and deactivation kinetics and are known to have a crucial contribution to the fast-spiking phenotype of certain neurons. AahG50, as a natural product extracted from Androctonus australis hec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bbd87aef13629b4c394f7a1fef750711
https://pubmed.ncbi.nlm.nih.gov/34830172