Childhood-onset lupus nephritis is characterized by complex interactions between kidney stroma and infiltrating immune cells.

Autor: Danaher P; Bruker Spatial Biology, Seattle, WA 98109, USA., Hasle N; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA., Nguyen ED; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA.; Seattle Children's Research Institute, Seattle, WA 98101, USA., Roberts JE; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA.; Seattle Children's Research Institute, Seattle, WA 98101, USA., Rosenwasser N; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA.; Seattle Children's Research Institute, Seattle, WA 98101, USA., Rickert C; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Hsieh EWY; Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.; Pediatrics, Section of Allergy and Immunology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA., Hayward K; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA.; Seattle Children's Research Institute, Seattle, WA 98101, USA., Okamura DM; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA.; Seattle Children's Research Institute, Seattle, WA 98101, USA., Alpers CE; Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA 98195, USA., Reed RC; Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA 98195, USA., Baxter SK; Sonoma Biotherapeutics, Seattle, WA 98119, USA., Jackson SW; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195, USA.; Seattle Children's Research Institute, Seattle, WA 98101, USA.; Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA 98195, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Nov 27; Vol. 16 (775), pp. eadl1666. Date of Electronic Publication: 2024 Nov 27.

Policy, Design, and Critical Reflections on Behavioral Health Crisis Services for People Experiencing Homelessness.

Autor: Jackson SW; Department of Psychiatry, SUNY Downstate Health Sciences University, 450 Clarkson Avenue, Brooklyn, NY 11203, USA. Electronic address: samuel.jackson@downstate.edu., Castillo EG; Department of Psychiatry, Center for Social Medicine, Jane and Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, 760 Westwood Plaza, Semel B7-435, Los Angeles, CA 90095, USA., Myrick KJ; Inseparable, 409 7th Street N.W. Suite 350 Washington, DC 20004, USA., Goldman ML; Department of Psychiatry and Behavioral Sciences, University of Washington, King County Department of Community and Human Resources, 401 5th Avenue, Seattle, WA 98104, USA.

Publikováno v: The Psychiatric clinics of North America [Psychiatr Clin North Am] 2024 Sep; Vol. 47 (3), pp. 577-593. Date of Electronic Publication: 2024 May 23.

NADPH oxidase exerts a B cell-intrinsic contribution to lupus risk by modulating endosomal TLR signals.

Autor: Liu S; Seattle Children's Research Institute , Seattle, WA, USA., Lagos J; Seattle Children's Research Institute , Seattle, WA, USA., Shumlak NM; Seattle Children's Research Institute , Seattle, WA, USA., Largent AD; Seattle Children's Research Institute , Seattle, WA, USA., Lewis STE; Seattle Children's Research Institute , Seattle, WA, USA., Holder U; Seattle Children's Research Institute , Seattle, WA, USA., Du SW; Seattle Children's Research Institute , Seattle, WA, USA., Liu Y; Institute of Biophysics, Chinese Academy of Sciences , Beijing, China., Hou B; Institute of Biophysics, Chinese Academy of Sciences , Beijing, China., Acharya M; Seattle Children's Research Institute , Seattle, WA, USA.; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA., Jackson SW; Seattle Children's Research Institute , Seattle, WA, USA.; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.; Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, USA.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2024 Apr 01; Vol. 221 (4). Date of Electronic Publication: 2024 Mar 05.

Unveiling the autoreactome: Proteome-wide immunological fingerprints reveal the promise of plasma cell depleting therapy.

Autor: Bodansky A; Department of Pediatrics, Division of Critical Care, University of California San Francisco, San Francisco, CA., Yu DJ; Diabetes Center, School of Medicine, University of California San Francisco, San Francisco, CA., Rallistan A; Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305., Kalaycioglu M; Institute of Immunity, Transplantation, and Infection (ITI), Stanford University, Stanford, CA 94305., Boonyaratanakornkit J; Fred Hutchinson Cancer Center, Seattle, WA, USA.; University of Washington School of Medicine, Seattle, WA, USA., Green DJ; Fred Hutchinson Cancer Center, Seattle, WA, USA.; University of Washington School of Medicine, Seattle, WA, USA., Gauthier J; Fred Hutchinson Cancer Center, Seattle, WA, USA.; University of Washington School of Medicine, Seattle, WA, USA., Turtle CJ; Fred Hutchinson Cancer Center, Seattle, WA, USA.; University of Washington School of Medicine, Seattle, WA, USA., Zorn K; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA., O'Donovan B; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA., Mandel-Brehm C; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA., Asaki J; Biomedical Sciences Program, University of California San Francisco, San Francisco, CA., Kortbawi H; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA.; Medical Scientist Training Program, University of California San Francisco, San Francisco, CA., Kung AF; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA.; Biological and Medical Informatics Program, University of California San Francisco, San Francisco, CA., Rackaityte E; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA., Wang CY; Chan Zuckerberg Biohub SF, San Francisco, CA., Saxena A; Chan Zuckerberg Biohub SF, San Francisco, CA., de Dios K; Diabetes Center, School of Medicine, University of California San Francisco, San Francisco, CA., Masi G; Department of Neurology, Yale School of Medicine, New Haven, CT.; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT., Nowak RJ; Department of Neurology, Yale School of Medicine, New Haven, CT., O'Connor KC; Department of Neurology, Yale School of Medicine, New Haven, CT.; Department of Immunobiology, School of Medicine, Yale University, New Haven, CT., Li H; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA., Diaz VE; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Casaletto KB; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Gontrum EQ; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Chan B; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Kramer JH; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Wilson MR; Weill Institute for Neurosciences, University of California San Francisco; San Francisco, CA.; Department of Neurology, University of California San Francisco; San Francisco, CA., Utz PJ; Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305., Hill JA; Fred Hutchinson Cancer Center, Seattle, WA, USA.; University of Washington School of Medicine, Seattle, WA, USA., Jackson SW; Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA.; Seattle Children's Research Institute, Seattle, WA.; Pediatrics, University of Washington School of Medicine, Seattle, WA., Anderson MS; Diabetes Center, School of Medicine, University of California San Francisco, San Francisco, CA., DeRisi JL; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA.; Chan Zuckerberg Biohub SF, San Francisco, CA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2023 Dec 20. Date of Electronic Publication: 2023 Dec 20.

Lupus Interference With B Cell Tolerance Across the Developmental Continuum.

Autor: Pemberton SE; Seattle Children's Research Institute, Seattle, Washington., Jackson SW; Seattle Children's Research Institute and Departments of Pediatrics and Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington.

Publikováno v: Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2023 Sep; Vol. 75 (9), pp. 1503-1505. Date of Electronic Publication: 2023 Jul 10.