232-LB: Housing Temperature Can Profoundly Influence Pharmacologically Induced Weight Loss Efficacy and Mode of Action in Diet-Induced Mice—A Cautionary Consideration for Human Translation

Autor: NATALIA PETERSEN, LOLA TORZ, MARINA K. GERSTENBERG, KENT PEDERSEN, SUZI H. MADSEN, SØREN ØSTERGAARD, BIRGITTE S. WULFF, SEBASTIAN B. JØRGENSEN, BIRGITTE S. ANDERSEN, BERIT Ø. CHRISTOFFERSEN, LINU M. JOHN, RUNE E. KUHRE

Publikováno v: Diabetes. 71

Objectives: Pre-clinical evaluation of drug efficacy on weight loss is usually done in diet-induced obese (DIO) mice housed at room temperature (∼22°C) , where the mice display adaptive thermogenic responses through brown adipose tissue (BAT) acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6bbb22ebf62a0ef59dedd20a33564db1
https://doi.org/10.2337/db22-232-lb

Inner histopathologic changes and disproportionate zone volumes in foetal growth plates following gestational hypoglycaemia in rats

Autor: Louise Pedersen, Jette Nowak, Pernille Tveden-Nyborg, Anne Marie Mølck, Birgitte M. Viuff, Jens Lykkesfeldt, Vivi F. H. Jensen, Suzi H. Madsen, Kristina Åkesson, Johannes Josef Fels, Ingrid Brück Bøgh, Fiona E. McGuigan, Charlotte Lund Rasmussen

Publikováno v: Scientific Reports
Jensen, V F H, Mølck, A-M, Bøgh, I B, Nowak, J, Viuff, B M, Rasmussen, C L M, Pedersen, L, Fels, J J, Madsen, S H, McGuigan, F E, Tveden-Nyborg, P, Lykkesfeldt, J & Akesson, K E 2020, ' Inner histopathologic changes and disproportionate zone volumes in foetal growth plates following gestational hypoglycaemia in rats ', Scientific Reports, vol. 10, no. 1, 5609 . https://doi.org/10.1038/s41598-020-62554-2
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)

Maternal hypoglycaemia throughout gestation until gestation day (GD)20 delays foetal growth and skeletal development. While partially prevented by return to normoglycaemia after completed organogenesis (GD17), underlying mechanisms are not fully unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05d0a741441758b801d4c3c944bb825
https://doi.org/10.1038/s41598-020-62554-2

Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase–mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation

Autor: Suzi H Madsen, Claus Christiansen, Bodil-Cecilie Sondergaard, Amanda J. Fosang, Morten A. Karsdal, E.U. Sumer, Helle Wulf

Publikováno v: Karsdal, M A, Sumer, E U, Wulf, H, Madsen, S H, Christiansen, C, Fosang, A J & Sondergaard, B-C 2007, ' Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase-mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation ', Arthritis & Rheumatism, vol. 56, no. 5, pp. 1549-58 . https://doi.org/10.1002/art.22599

Udgivelsesdato: 2007-May OBJECTIVE: Calcitonin has been suggested to have chondroprotective effects. One signaling pathway of calcitonin is via the second messenger cAMP. We undertook this study to investigate whether increased cAMP levels in chondro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47106dd7ee98a3dd7a231ec897856189
https://doi.org/10.1002/art.22599

Glucocorticoids exert context-dependent effects on cells of the joint in vitro

Autor: Morten A. Karsdal, Søren T. Christensen, Kim Henriksen, Anne-Christine Bay-Jensen, Francis M. Sverdrup, Suzi H Madsen, Kim Vietz Andreassen

Publikováno v: Steroids. 76(13)

Introduction Glucocorticoids are known to attenuate bone formation in vivo leading to decreased bone volume and increased risk of fractures, whereas effects on the joint tissue are less characterized. However, glucocorticoids appear to have a reducin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ca97473d9e8d58f6ec53a145573019
https://pubmed.ncbi.nlm.nih.gov/21855558

Investigation of the direct effects of salmon calcitonin on human osteoarthritic chondrocytes

Autor: Anne-Christine Bay-Jensen, Morten A. Karsdal, Christian Pedersen, Sarah Juel Paulsen, Bodil-Cecilie Sondergaard, Toni Segovia-Silvestre, T. Christiansen, Suzi H Madsen

Publikováno v: BMC Musculoskeletal Disorders
BMC Musculoskeletal Disorders, Vol 11, Iss 1, p 62 (2010)

Background Calcitonin has been demonstrated to have chondroprotective effects under pre-clinical settings. It is debated whether this effect is mediated through subchondral-bone, directly on cartilage or both in combination. We investigated possible

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd098b5629deea6db5e485c88f5db7d
https://pubmed.ncbi.nlm.nih.gov/20367884