Zobrazeno 1 - 10 of 155 pro vyhledávání: '"SUSUMU NAKATA"'
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Akademický článek
Identification of c-Met as a novel target of γ-glutamylcyclotransferase
Autor: Yumiko Saito, Keiko Taniguchi, Hiromi Ii, Mano Horinaka, Susumu Kageyama, Susumu Nakata, Osamu Ukimura, Toshiyuki Sakai
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract γ-Glutamylcyclotransferase (GGCT) is highly expressed in multiple types of cancer tissues and its knockdown suppresses the growth of cancer cells in vitro and in vivo. Although GGCT is a promising target for cancer therapy, the mechanisms u
Externí odkaz: https://doaj.org/article/636da57f22f844ebac82221b2e349830
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2
Akademický článek
Polycomb group protein Ezh2 regulates hepatic progenitor cell proliferation and differentiation in murine embryonic liver.
Autor: Hiroyuki Koike, Rie Ouchi, Yasuharu Ueno, Susumu Nakata, Yuta Obana, Keisuke Sekine, Yun-Wen Zheng, Takanori Takebe, Kyoichi Isono, Haruhiko Koseki, Hideki Taniguchi
Publikováno v: PLoS ONE, Vol 9, Iss 8, p e104776 (2014)
In embryonic liver, hepatic progenitor cells are actively proliferating and generate a fundamental cellular pool for establishing parenchymal components. However, the molecular basis for the expansion of the progenitors maintaining their immature sta
Externí odkaz: https://doaj.org/article/2aff435ecb794bf48a3423b795ec44e0
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6
The γ-Glutamylcyclotransferase Inhibitor Pro-GA Induces an Antiproliferative Effect Through the Generation of Mitochondrial Reactive Oxygen Species
Autor: Hiromi, Ii, Keiko, Taniguchi, Taku, Yoshiya, Yukie, Nohara, Susumu, Kageyama, Akihiro, Kawauchi, Susumu, Nakata
Publikováno v: Anticancer Research. 42:4311-4317
γ-Glutamylcyclotransferase (GGCT) is up-regulated in a broad range of cancers, including breast cancer, and GGCT inhibition has been shown to be a promising strategy for therapy. Herein, we evaluated the efficacy and mechanism of action of pro-GA, a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f0eee97a005405521ca12e51728f71
https://doi.org/10.21873/anticanres.15931
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7
Myb Repression Mediates Stat5b-knockdown-induced Apoptosis and Inhibits Proliferation of Glioblastoma Stem Cells
Autor: CHIAMI MOYAMA, MITSUGU FUJITA, HITOSHI OKAMOTO, HIROMI II, SUSUMU NAKATA
Publikováno v: Cancer Genomics Proteomics
Background/Aim: Glioblastoma is the most common and aggressive malignant brain tumor in adults, and glioblastoma stem cells (GSCs) contribute to treatment resistance and recurrence. Inhibition of Stat5b in GSCs suppresses cell proliferation and induc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d382ef6ff2434cd93e622c5eba1f5a1
https://europepmc.org/articles/PMC9989674/
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9
Fluorizoline Blocks the Interaction between Prohibitin-2 and γ-Glutamylcyclotransferase and Induces p21Waf1/Cip1 Expression in MCF7 Breast Cancer Cells
Autor: Kota Ando, Chiami Moyama, Shota Ando, Keiko Taniguchi, Laurent Désaubry, Susumu Kageyama, Akihiro Kawauchi, Susumu Nakata, Hiroko Takagi, Hiromi, Nora Chouha, Ryohei Matsuda
Publikováno v: Molecular Pharmacology. 101:78-86
Prohibitin-2 (PHB2) is a scaffold protein that has pleiotropic functions, which include interacting with γ-glutamylcyclotransferase (GGCT) in the cytoplasm and repressing the transcriptional activities of the p21Waf1/Cip (p21) gene in the nucleus. T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9d456054a7f7cd61df4a07c9218b95
https://doi.org/10.1124/molpharm.121.000334
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