FBXW7 tumor suppressor regulation by dualspecificity tyrosine-regulated kinase 2

Autor: Rafael Jiménez-Izquierdo, Rosario Morrugares, Lucía Suanes-Cobos, Alejandro Correa-Sáez, Martín Garrido-Rodríguez, Laura Cerero-Tejero, Omar M. Khan, Susana de la Luna, Rocío Sancho, Marco A. Calzado

Publikováno v: Cell Death and Disease, Vol 14, Iss 3, Pp 1-14 (2023)

Abstract FBXW7 is a member of the F-box protein family, which functions as the substrate recognition component of the SCF E3 ubiquitin ligase. FBXW7 is a main tumor suppressor due to its ability to control proteasome-mediated degradation of several o

Externí odkaz: https://doaj.org/article/9aee63207e8647eaa6ccbe6db4bdeada

Loss of the DYRK1A Protein Kinase Results in the Reduction in Ribosomal Protein Gene Expression, Ribosome Mass and Reduced Translation

Autor: Chiara Di Vona, Laura Barba, Roberto Ferrari, Susana de la Luna

Publikováno v: Biomolecules, Vol 14, Iss 1, p 31 (2023)

Ribosomal proteins (RPs) are evolutionary conserved proteins that are essential for protein translation. RP expression must be tightly regulated to ensure the appropriate assembly of ribosomes and to respond to the growth demands of cells. The elemen

Externí odkaz: https://doaj.org/article/6a6e93ff8165461fb67a90cc0045adb5

Impaired development of neocortical circuits contributes to the neurological alterations in DYRK1A haploinsufficiency syndrome

Autor: Juan Arranz, Elisa Balducci, Krisztina Arató, Gentzane Sánchez-Elexpuru, Sònia Najas, Alberto Parras, Elena Rebollo, Isabel Pijuan, Ionas Erb, Gaetano Verde, Ignasi Sahun, Maria J. Barallobre, José J. Lucas, Marina P. Sánchez, Susana de la Luna, Maria L. Arbonés

Publikováno v: Neurobiology of Disease, Vol 127, Iss , Pp 210-222 (2019)

Autism spectrum disorders are early onset neurodevelopmental disorders characterized by deficits in social communication and restricted repetitive behaviors, yet they are quite heterogeneous in terms of their genetic basis and phenotypic manifestatio

Externí odkaz: https://doaj.org/article/28d366b9092f47de8d16633beced1031

DYRK1A Kinase Positively Regulates Angiogenic Responses in Endothelial Cells

Autor: Esteban J. Rozen, Julia Roewenstrunk, María José Barallobre, Chiara Di Vona, Carole Jung, Ana F. Figueiredo, Jeroni Luna, Cristina Fillat, Maria L. Arbonés, Mariona Graupera, Miguel A. Valverde, Susana de la Luna

Publikováno v: Cell Reports, Vol 23, Iss 6, Pp 1867-1878 (2018)

Summary: Angiogenesis is a highly regulated process essential for organ development and maintenance, and its deregulation contributes to inflammation, cardiac disorders, and cancer. The Ca2+/nuclear factor of activated T cells (NFAT) signaling pathwa

Externí odkaz: https://doaj.org/article/91b2dfb0e22745f7bf0a389f39323eb3

Impaired development of neocortical circuits contributes to the neurological alterations in DYRK1A haploinsufficiency syndrome

Autor: Maria L. Arbonés, José J. Lucas, Susana de la Luna, Elisa Balducci, Marina P. Sánchez, Ignasi Sahún, Maria Jose Barallobre, Elena Rebollo, Ionas Erb, Alberto Parras, Sonia Najas, Gaetano Verde, Juan Arranz, Gentzane Sánchez-Elexpuru, Krisztina Arató, Isabel Pijuan

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
Neurobiology of Disease, Vol 127, Iss, Pp 210-222 (2019)
Neurobiol Dis
Digital.CSIC. Repositorio Institucional del CSIC

Autism spectrum disorders are early onset neurodevelopmental disorders characterized by deficits in social communication and restricted repetitive behaviors, yet they are quite heterogeneous in terms of their genetic basis and phenotypic manifestatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1fd7d10c37028bef07f2b1159771a7
https://doi.org/10.1016/j.nbd.2019.02.022