Zobrazeno 1 - 10 of 117 pro vyhledávání: '"SUNGPIL YOON"'
1
Akademický článek
The roles and mechanisms of coding and noncoding RNA variations in cancer
Autor: Sang Yean Kim, Min Jeong Na, Sungpil Yoon, Eunbi Shin, Jin Woong Ha, Soyoung Jeon, Suk Woo Nam
Publikováno v: Experimental and Molecular Medicine, Vol 56, Iss 9, Pp 1909-1920 (2024)
Abstract Functional variations in coding and noncoding RNAs are crucial in tumorigenesis, with cancer-specific alterations often resulting from chemical modifications and posttranscriptional processes mediated by enzymes. These RNA variations have be
Externí odkaz: https://doaj.org/article/431548a016714929969eff7f510251f3
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3
Akademický článek
Low-Dose Crizotinib, a Tyrosine Kinase Inhibitor, Highly and Specifically Sensitizes P-Glycoprotein-Overexpressing Chemoresistant Cancer Cells Through Induction of Late Apoptosis in vivo and in vitro
Autor: Kyeong Seok Kim, Chunxue Jiang, Ji Young Kim, Jae Hyeon Park, Hae Ri Kim, Su Hyun Lee, Hyung Sik Kim, Sungpil Yoon
Publikováno v: Frontiers in Oncology, Vol 10 (2020)
We investigated possible conditions or drugs that could target P-glycoprotein (P-gp)-overexpressing drug-resistant KBV20C cancer cells. Specifically, we focused on identifying a single treatment with a relatively low half maximal inhibitory concentra
Externí odkaz: https://doaj.org/article/e5635f5744cf4f6c97391ab547c115a8
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4
Akademický článek
Biological Evaluation of Oxindole Derivative as a Novel Anticancer Agent against Human Kidney Carcinoma Cells
Autor: Prasanta Dey, Amit Kundu, Sang Hoon Han, Kyeong-Seok Kim, Jae Hyeon Park, Sungpil Yoon, In Su Kim, Hyung Sik Kim
Publikováno v: Biomolecules, Vol 10, Iss 9, p 1260 (2020)
Renal cell carcinoma has emerged as one of the leading causes of cancer-related deaths in the USA. Here, we examined the anticancer profile of oxindole derivatives (SH-859) in human renal cancer cells. Targeting 786-O cells by SH-859 inhibited cell g
Externí odkaz: https://doaj.org/article/d7f701efd000428380fbb54ca316354d
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6
Terconazole, an Azole Antifungal Drug, Increases Cytotoxicity in Antimitotic Drug-Treated Resistant Cancer Cells with Substrate-Specific P-gp Inhibitory Activity
Autor: Ji Sun Lee, Yunmoon Oh, Jae Hyeon Park, So Young Kyung, Hyung Sik Kim, Sungpil Yoon
Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 22; Pages: 13809
Azole antifungal drugs have been shown to enhance the cytotoxicity of antimitotic drugs in P-glycoprotein (P-gp)-overexpressing-resistant cancer cells. Herein, we examined two azole antifungal drugs, terconazole (TCZ) and butoconazole (BTZ), previous
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0c6409fe68d322aa330c84ea948fa17
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7
Combination Treatment Using Pyruvate Kinase M2 Inhibitors for the Sensitization of High Density Triple-negative Breast Cancer Cells
Autor: JI SUN LEE, YUNMOON OH, JIN-SOL LEE, JAE HYEON PARK, JOO-KYUNG SHIN, JOO-HEE HAN, HYUNG SIK KIM, SUNGPIL YOON
Publikováno v: In Vivo
Background/Aim: Few studies have examined the correlation between pyruvate kinase M2 (PKM2) overexpression and triple-negative breast cancer (TNBC). TNBC is considered incurable with the currently available treatments, highlighting the need for alter
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd7d5026a82952a3b65b0d8e2e625b01
https://pubmed.ncbi.nlm.nih.gov/36099094
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8
JAK2 Inhibitor, Fedratinib, Inhibits P-gp Activity and Co-Treatment Induces Cytotoxicity in Antimitotic Drug-Treated P-gp Overexpressing Resistant KBV20C Cancer Cells
Autor: Yunmoon Oh, Jin-Sol Lee, Ji Sun Lee, Jae Hyeon Park, Hyung Sik Kim, Sungpil Yoon
Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 9; Pages: 4597
P-glycoprotein (P-gp) overexpression is one of the major mechanisms of multidrug resistance (MDR). Previously, co-treatment with Janus kinase 2 (JAK2) inhibitors sensitized P-gp-overexpressing drug-resistant cancer cells. In this study, we assessed t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b3f23e3e1cfeb091f8e2100528a4e4
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9
Glycolytic Metabolic Remodeling by the Truncate of Glioma-Associated Oncogene Homolog 1 in Triple-Negative Breast Cancer Cells
Autor: Su Hyun Lee, Ji Sun Lee, Jae Hyeon Park, Sungpil Yoon, Kwang Youl Lee, Hyung Sik Kim
Publikováno v: Journal of Cancer. 13(10)
Hedgehog (Hh) signaling pathway plays an essential role in embryonic development, tissue regeneration, and stem cell renewal. In particular, terminal effectors of the Hh signaling pathway are associated with the regulation of glioma-associated oncoge
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b97ea758ddf7cfd87f9affab71fbb571
https://pubmed.ncbi.nlm.nih.gov/36046646
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10
PKM2 Is Overexpressed in Glioma Tissues, and Its Inhibition Highly Increases Late Apoptosis in U87MG Cells With Low-density Specificity
Autor: JAE HYEON PARK, JIN-SOL LEE, YUNMOON OH, JI SUN LEE, HAE EUN PARK, HAEUN LEE, YEON SU PARK, SO YOUNG KYUNG, HYUNG SIK KIM, SUNGPIL YOON
Publikováno v: In Vivo
Background/Aim: Pyruvate kinase M2 (PKM2) functions as an important rate-limiting enzyme in aerobic glycolysis and is involved in tumor initiation and progression. However, there are few studies on the correlation between PKM2 expression and its role
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::432c11b85f86060272bce94c94175c0e
https://europepmc.org/articles/PMC8931915/
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