Zobrazeno 1 - 10
of 78
pro vyhledávání: '"SUNG, YOUNG SHIN"'
Autor:
Hon Yan Kelvin Yip, Sung-Young Shin, Annabel Chee, Ching-Seng Ang, Fernando J. Rossello, Lee Hwa Wong, Lan K. Nguyen, Antonella Papa
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-21 (2024)
Abstract Utility of PI3Kα inhibitors like BYL719 is limited by the acquisition of genetic and non-genetic mechanisms of resistance which cause disease recurrence. Several combination therapies based on PI3K inhibition have been proposed, but a way t
Externí odkaz:
https://doaj.org/article/aa1b44a3480a4139b466b6fbd7dfcf75
Autor:
Milad Ghomlaghi, Mandy Theocharous, Nhan Hoang, Sung-Young Shin, Alex von Kriegsheim, Eric O’ Neill, Tao Zhang, Lan K. Nguyen
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109031- (2024)
Summary: The transcriptional co-activator YAP forms complexes with distinct transcription factors, controlling cell fate decisions, such as proliferation and apoptosis. However, the mechanisms underlying its context-dependent function are poorly defi
Externí odkaz:
https://doaj.org/article/ac43d1e023b14adeb764bd7c42e1ff0f
Autor:
Sung-Young Shin, Margaret M. Centenera, Joshua T. Hodgson, Elizabeth V. Nguyen, Lisa M. Butler, Roger J. Daly, Lan K. Nguyen
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Precision medicine has emerged as an important paradigm in oncology, driven by the significant heterogeneity of individual patients’ tumour. A key prerequisite for effective implementation of precision oncology is the development of companion bioma
Externí odkaz:
https://doaj.org/article/cdb6f5dd510b4c01b6e997750e20fb56
Autor:
Nicole J. Chew, Terry C. C. Lim Kam Sian, Elizabeth V. Nguyen, Sung-Young Shin, Jessica Yang, Mun N. Hui, Niantao Deng, Catriona A. McLean, Alana L. Welm, Elgene Lim, Peter Gregory, Tim Nottle, Tali Lang, Melissa Vereker, Gary Richardson, Genevieve Kerr, Diana Micati, Thierry Jardé, Helen E. Abud, Rachel S. Lee, Alex Swarbrick, Roger J. Daly
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-20 (2021)
Abstract Background Particular breast cancer subtypes pose a clinical challenge due to limited targeted therapeutic options and/or poor responses to the existing targeted therapies. While cell lines provide useful pre-clinical models, patient-derived
Externí odkaz:
https://doaj.org/article/42109f40f72f49ee97c97e5cf45b49ce
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 9, p e1008513 (2021)
The PI3K/MTOR signalling network regulates a broad array of critical cellular processes, including cell growth, metabolism and autophagy. The mechanistic target of rapamycin (MTOR) kinase functions as a core catalytic subunit in two physically and fu
Externí odkaz:
https://doaj.org/article/712302b6419c4aefa8ed03c345a6d2de
Autor:
Zhiduan Su, James G. Burchfield, Pengyi Yang, Sean J. Humphrey, Guang Yang, Deanne Francis, Sabina Yasmin, Sung-Young Shin, Dougall M. Norris, Alison L. Kearney, Miro A. Astore, Jonathan Scavuzzo, Kelsey H. Fisher-Wellman, Qiao-Ping Wang, Benjamin L. Parker, G. Gregory Neely, Fatemeh Vafaee, Joyce Chiu, Reichelle Yeo, Philip J. Hogg, Daniel J. Fazakerley, Lan K. Nguyen, Serdar Kuyucak, David E. James
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Crosstalk between protein oxidation and other post-translational modifications remains unexplored. Here, the authors map the phosphoproteome, cysteine redox proteome and total proteome of adipocytes under acute oxidative stress and reveal crosstalk b
Externí odkaz:
https://doaj.org/article/100de65dcd654d9fbe6eaea348b3c57b
Autor:
Dougall Norris, Pengyi Yang, Sung-Young Shin, Alison L. Kearney, Hani Jieun Kim, Thomas Geddes, Alistair M. Senior, Daniel J. Fazakerley, Lan K. Nguyen, David E. James, James G. Burchfield
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102118- (2021)
Summary: Insulin's activation of PI3K/Akt signaling, stimulates glucose uptake by enhancing delivery of GLUT4 to the cell surface. Here we examined the origins of intercellular heterogeneity in insulin signaling. Akt activation alone accounted for ~2
Externí odkaz:
https://doaj.org/article/011f0f4f926048ed890f7a576d06d29b
Autor:
Xue Yang, Miguel I. Cruz, Elizabeth V. Nguyen, Cheng Huang, Ralf B. Schittenhelm, Jennii Luu, Karla J. Cowley, Sung-Young Shin, Lan K. Nguyen, Terry C. C. Lim Kam Sian, Kimberley C. Clark, Kaylene J. Simpson, Xiuquan Ma, Roger J. Daly
Publikováno v:
Oncogene. 42:833-847
We have determined that expression of the pseudokinase NRBP1 positively associates with poor prognosis in triple negative breast cancer (TNBC) and is required for efficient migration, invasion and proliferation of TNBC cells in culture as well as gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f114142a5270a28a0aad87f8352918d
https://doi.org/10.1038/s41388-023-02594-w
https://doi.org/10.1038/s41388-023-02594-w
Autor:
Sung-Young Shin, Lan K. Nguyen
The widespread development of resistance to cancer monotherapies has prompted the need to identify combinatorial treatment approaches that circumvent drug resistance and achieve more durable clinical benefit. However, given the vast space of possible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1295acd9b9f091023bfcd5a8b047699
https://doi.org/10.1101/2023.04.07.536087
https://doi.org/10.1101/2023.04.07.536087
Supplementary Data C from Functional Roles of Multiple Feedback Loops in Extracellular Signal-Regulated Kinase and Wnt Signaling Pathways That Regulate Epithelial-Mesenchymal Transition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7856edcc34d403b82b846bd7b63ec14b
https://doi.org/10.1158/0008-5472.22385484.v1
https://doi.org/10.1158/0008-5472.22385484.v1