Zobrazeno 1 - 10
of 10
pro vyhledávání: '"SULT, sulfotransferase"'
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 1, Pp 19-32 (2020)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Microbes inhabiting the intestinal tract of humans represent a site for xenobiotic metabolism. The gut microbiome, the collection of microorganisms in the gastrointestinal tract, can alter the metabolic outcome of pharmaceuticals, environmental toxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511b159fb05311b8d1af4e8394064073
http://www.sciencedirect.com/science/article/pii/S2211383519309736
http://www.sciencedirect.com/science/article/pii/S2211383519309736
Publikováno v:
The Journal of Biological Chemistry
Polychlorinated bisphenols (PCBs) continue to contaminate food chains globally where they concentrate in tissues and disrupt the endocrine systems of species throughout the ecosphere. Hydroxylated PCBs (OH-PCBs) are major PCB metabolites and high-aff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3130b955e53aa1e189cb7164a022a817
https://pubmed.ncbi.nlm.nih.gov/33524392
https://pubmed.ncbi.nlm.nih.gov/33524392
Publikováno v:
The Journal of Biological Chemistry
Controlling unmodified serotonin levels in brain synapses is a primary objective when treating major depressive disorder - a disease that afflicts ~20% of the world's population. Roughly 60% of patients respond poorly to first-line treatments and thu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cad720d003b48d451231b4b31986a0c
http://europepmc.org/articles/PMC7948405
http://europepmc.org/articles/PMC7948405
Autor:
Lars-Oliver Klotz, Holger Steinbrenner
Publikováno v:
Redox Biology, Vol 13, Iss C, Pp 646-654 (2017)
Redox Biology
Redox Biology
Cells adapt to an exposure to xenobiotics by upregulating the biosynthesis of proteins involved in xenobiotic metabolism. This is achieved largely via activation of cellular xenosensors that modulate gene expression. Biotransformation of xenobiotics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d0f26e0e348c4330eb66841f6b46a65
https://doi.org/10.1016/j.redox.2017.07.015
https://doi.org/10.1016/j.redox.2017.07.015
Autor:
Susanna S.T. Lee, Wing-Tai Cheung, Lu Feng, Kai Wang, Xing Liu, Yan-Chun Chan, Shannon Wing-Ngor Au, Pui-Kin So
Publikováno v:
Journal of Lipid Research, Vol 62, Iss, Pp 100074-(2021)
Journal of Lipid Research
Journal of Lipid Research
Cytosolic sulfotransferases (SULTs) catalyze the transfer of a sulfonate group from the cofactor 3’-phosphoadenosine 5’-phosphosulfate to a hydroxyl (OH) containing substrate and play a critical role in the homeostasis of endogenous compounds, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ddf4c4d5ce2e5fe2b987d171226e7f5
https://doi.org/10.1016/j.jlr.2021.100074
https://doi.org/10.1016/j.jlr.2021.100074
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 6, Iss 5, Pp 475-491 (2016)
Acta Pharmaceutica Sinica B, Vol 6, Iss 5, Pp 475-491 (2016)
Intestine is responsible for the biotransformation of many orally-exposed chemicals. The constitutive androstane receptor (CAR/Nr1i3) is known to up-regulate many genes encoding drug-metabolizing enzymes and transporters (drug-processing genes/DPGs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f228bc5a87c2c28e40433b38832e9981
Publikováno v:
Molecular and Cellular Endocrinology
Androgens play an important role in metabolic homeostasis and reproductive health in both men and women. Androgen signalling is dependent on androgen receptor activation, mostly by testosterone and 5α-dihydrotestosterone. However, the intracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5107efbc47e71ea8aa284d5bb9b96645
https://pubmed.ncbi.nlm.nih.gov/28865807
https://pubmed.ncbi.nlm.nih.gov/28865807
Autor:
László Abrankó, Asimina Kerimi, Gary Williamson, Charlotte Grootaert, John Van Camp, Sarka Tumova, Evelien Van Rymenant
Publikováno v:
The Journal of Nutritional Biochemistry
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
Dietary fiber-derived short-chain fatty acids (SCFA) and phenolics produced by the gut microbiome have multiple effects on health. We have tested the hypothesis that long-term exposure to physiological concentrations of SCFA can affect the transport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4397544892f45ef303632869072140a0
https://pubmed.ncbi.nlm.nih.gov/27840292
https://pubmed.ncbi.nlm.nih.gov/27840292
Autor:
Collins SL; Department of Biochemistry, Microbiology, and Molecular Biology, the Pennsylvania State University, University Park, PA 16802, USA., Patterson AD; Department of Veterinary and Biomedical Science, the Pennsylvania State University, University Park, PA 16802, USA.
Publikováno v:
Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2020 Jan; Vol. 10 (1), pp. 19-32. Date of Electronic Publication: 2019 Dec 10.
Autor:
Park S; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA., Cheng SL; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA., Cui JY; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA.
Publikováno v:
Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2016 Sep; Vol. 6 (5), pp. 475-491. Date of Electronic Publication: 2016 Aug 02.