Zobrazeno 1 - 10
of 175
pro vyhledávání: '"SULF2"'
Autor:
Pritha Mukherjee, Xin Zhou, Susana Galli, Bruce Davidson, Lihua Zhang, Jaeil Ahn, Reem Aljuhani, Julius Benicky, Laurie Ailles, Vitor H. Pomin, Mark Olsen, Radoslav Goldman
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4998 (2024)
Aspartate β-hydroxylase (ASPH) is a protein associated with malignancy in a wide range of tumors. We hypothesize that inhibition of ASPH activity could have anti-tumor properties in patients with head and neck cancer. In this study, we screened tumo
Externí odkaz:
https://doaj.org/article/6d1b9848fe6f4ab58bf0b8b5a3da28ea
Publikováno v:
Heliyon, Vol 9, Iss 2, Pp e13613- (2023)
Background: Adrenocortical carcinoma (ACC) represents the rare urological epithelial cancer of urinary tract, which has a large mass and is usually diagnosed at the advanced stage, thus inducing the poor prognosis. As a result, early detection and di
Externí odkaz:
https://doaj.org/article/f8cd84e921f14a31a0a6b3035c4a3b63
Akademický článek
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Akademický článek
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Publikováno v:
Mathematical Biosciences and Engineering, Vol 16, Iss 5, Pp 4607-4621 (2019)
Objective To explore the potential mechanism which miR-527 targeting the heparan sulfate 6-O-endosulfatase (SULF2) regulates TGF-β/SMAD signaling pathway induced epithelial-mesenchymal transition (EMT) in non-small-cell lung cancer (NSCLC). Methods
Externí odkaz:
https://doaj.org/article/63c3b9b7cf65441dab0d3a44883df4af
Akademický článek
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Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
BackgroundSulfatase 2 (SULF2) removes the 6-O-sulfate groups from heparan sulfate proteoglycans (HSPG) and consequently alters the binding sites for various signaling molecules. Here, we elucidated the role of SULF2 in the differentiation of hepatic
Externí odkaz:
https://doaj.org/article/2ca7ad420c7b470098fa0ea4258d357d
Autor:
Yang Yang, Jaeil Ahn, Rekha Raghunathan, Bhaskar V. Kallakury, Bruce Davidson, Zuzana Brnakova Kennedy, Joseph Zaia, Radoslav Goldman
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Sulfation of heparan sulfate proteoglycans (HSPG) regulates signaling of growth factor receptors via specific interactions with the sulfate groups. 6-O-Sulfation of HSPG is an impactful modification regulated by the activities of dedicated extracellu
Externí odkaz:
https://doaj.org/article/92fd7849509b421b86479f0e80d7c514
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3769 (2022)
Signalling activities are tightly regulated to control cellular responses. Heparan sulfate proteoglycans (HSPGs) at the cell membrane and extracellular matrix regulate ligand availability and interaction with a range of key receptors. SULF1 and SULF2
Externí odkaz:
https://doaj.org/article/6fcf8074ec36459a93840d3559b59fed
Publikováno v:
Brazilian Journal of Medical and Biological Research, Vol 53, Iss 2 (2020)
The objective of this study was to explore the role of the SULF2-mediated ERK/AKT signaling pathway in cervical cancer. SULF2 expression was detected in tumor tissues and tumor-adjacent normal tissues from cervical cancer patients. HeLa cells were di
Externí odkaz:
https://doaj.org/article/c59ed4002e654d16af200b0877aaf965