Zobrazeno 1 - 9
of 9
pro vyhledávání: '"SUKRATI KANOJIA"'
Autor:
Xin Tong, Zunaira Chaudhry, Chih-Chun Lee, Robert N. Bone, Sukrati Kanojia, Judith Maddatu, Paul Sohn, Staci A. Weaver, Morgan A. Robertson, Irina Petrache, Carmella Evans-Molina, Tatsuyoshi Kono
Publikováno v:
Molecular Metabolism, Vol 37, Iss , Pp 100975- (2020)
Objectives: Epidemiological studies indicate that first- and second-hand cigarette smoke (CS) exposure are important risk factors for the development of type 2 diabetes (T2D). Additionally, elevated diabetes risk has been reported to occur within a s
Externí odkaz:
https://doaj.org/article/0fe5d12c31684de0b963d0b776686fe2
Autor:
Rebecca K Davidson, Staci A Weaver, Nolan Casey, Sukrati Kanojia, Elise Hogarth, Rebecca Schneider Aguirre, Emily K Sims, Carmella Evans-Molina, Jason M Spaeth
Publikováno v:
J Mol Endocrinol
Type 2 diabetes (T2D) is associated with loss of transcription factors (TFs) from a subset of failing β-cells. Among these TFs is Pdx1, which controls the expression of numerous genes involved in maintaining β-cell function and identity. Pdx1 activ
Autor:
Rebecca K. Davidson, Sukrati Kanojia, Wenting Wu, Tatsuyoshi Kono, Jerry Xu, Meredith Osmulski, Robert N. Bone, Nolan Casey, Carmella Evans-Molina, Emily K. Sims, Jason M. Spaeth
The transcriptional activity of Pdx1 is modulated by a diverse array of coregulatory factors that govern chromatin accessibility, histone modifications, and nucleosome distribution. We previously identified the Chd4 subunit of the nucleosome remodeli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a03ae668fe75f1bb64d63f350f20ed1
https://doi.org/10.2337/figshare.22236679
https://doi.org/10.2337/figshare.22236679
Publikováno v:
Diabetes. 71
During diabetes progression, a subset of failing β-cells incurs a loss of transcription factors (TFs) such as Pdx1, which drives expression of numerous β-cell functional genes including Ins2, MafA, and Slc2a2. Like other TFs, Pdx1 requires the recr
Publikováno v:
Diabetes. 71
The main function of the pancreatic β-cell is glucose-stimulated insulin secretion (GSIS) which serves to maintain whole body glucose homeostasis. Under type 2 diabetic conditions, a subset of β-cells fail and lose expression of key transcription f
Publikováno v:
Diabetes. 70
Diabetes progression is partly characterized by a loss of key transcription factors (TFs) in a subset of failing β-cells. Among these TFs is Pdx1, which coordinates the expression of numerous genes related to β-cell function (MafA, Ins2, Ucn3), mit
Publikováno v:
Diabetes. 70
Pancreatic β-cells are crucial for glucose-stimulated insulin secretion (GSIS) and whole-body glucose homeostasis. Dysfunctional β-cell mass results in diabetes mellitus (DM), a growing pandemic causing global economic burden. Pancreas-enriched tra
Publikováno v:
Endocrinology
Islet β-cell dysfunction that leads to impaired insulin secretion is a principal source of pathology of diabetes. In type 2 diabetes, this breakdown in β-cell health is associated with compromised islet-enriched transcription factor (TF) activity t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9abe64b99fad33f68306d47fca1c5b40
https://europepmc.org/articles/PMC7749714/
https://europepmc.org/articles/PMC7749714/
Autor:
Judith Maddatu, Sukrati Kanojia, Morgan A. Robertson, Tatsuyoshi Kono, Xin Tong, Paul Sohn, Robert N. Bone, Zunaira Chaudhry, Carmella Evans-Molina, Irina Petrache, Chih-Chun Lee
ObjectivesEpidemiological studies indicate that first- and second-hand cigarette smoke (CS) exposure are important risk factors for the development of type 2 diabetes (T2D). Additionally, elevated diabetes risk has been reported to occur within a sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69cfda46670f95b13e9c872afbcf4ed3