Zobrazeno 1 - 10
of 35
pro vyhledávání: '"SUE MEI LIM"'
Autor:
Patricia Gerdes, Sue Mei Lim, Adam D. Ewing, Michael R. Larcombe, Dorothy Chan, Francisco J. Sanchez-Luque, Lucinda Walker, Alexander L. Carleton, Cini James, Anja S. Knaupp, Patricia E. Carreira, Christian M. Nefzger, Ryan Lister, Sandra R. Richardson, Jose M. Polo, Geoffrey J. Faulkner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Retrotransposons are mobile genetic elements normally repressed by DNA methylation in differentiated cells. Here, the authors show that DNA hypomethylation in mouse induced pluripotent stem cells allows retrotransposons to jump, but this can be block
Externí odkaz:
https://doaj.org/article/b8c17138d7be4d378e40d7894f019bb7
Autor:
Christian M. Nefzger, Fernando J. Rossello, Joseph Chen, Xiaodong Liu, Anja S. Knaupp, Jaber Firas, Jacob M. Paynter, Jahnvi Pflueger, Sam Buckberry, Sue Mei Lim, Brenda Williams, Sara Alaei, Keshav Faye-Chauhan, Enrico Petretto, Susan K. Nilsson, Ryan Lister, Mirana Ramialison, David R. Powell, Owen J.L. Rackham, Jose M. Polo
Publikováno v:
Cell Reports, Vol 21, Iss 10, Pp 2649-2660 (2017)
Summary: Our current understanding of induced pluripotent stem cell (iPSC) generation has almost entirely been shaped by studies performed on reprogramming fibroblasts. However, whether the resulting model universally applies to the reprogramming pro
Externí odkaz:
https://doaj.org/article/fcf8a1ac389940f5bfb79e4118d8977d
Autor:
Lloyd A Pereira, Michael S Wong, Sue Mei Lim, Alexandra Sides, Edouard G Stanley, Andrew G Elefanty
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28394 (2011)
Mixl1 is a homeodomain transcription factor required for mesoderm and endoderm patterning during mammalian embryogenesis. Despite its crucial function in development, co-factors that modulate the activity of Mixl1 remain poorly defined. Here we repor
Externí odkaz:
https://doaj.org/article/70bf5739252c432cb0310fb748e0f635
Publikováno v:
Annals of the Academy of Medicine, Singapore. 50:703-711
Introduction: Vaccination remains a key strategy to living endemically with COVID-19. The Pfizer-BioNTech COVID-19 vaccine was first granted interim authorisation for use in Singapore in December 2020. With overseas studies published about the safety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::064551f39a1306a5bc4f3792d413232b
https://doi.org/10.47102/annals-acadmedsg.2021160
https://doi.org/10.47102/annals-acadmedsg.2021160
Autor:
Amander T. Clark, Jan Schröder, Daniel Poppe, Joseph Chen, Yu Bo Yang Sun, Ryan Lister, Sue Mei Lim, Jose M. Polo, Jia Ping Tan, Xiaodong Liu, Monika Mohenska, Jennifer Zenker, Owen J. L. Rackham, Guizhi Sun, Yichen Zhou, John F. Ouyang, Asma Aberkane
Publikováno v:
Nature. 591:627-632
Human pluripotent and trophoblast stem cells have been essential alternatives to blastocysts for understanding early human development1–4. However, these simple culture systems lack the complexity to adequately model the spatiotemporal cellular and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11a37553d4d48ea0a7c78732112b1de8
https://doi.org/10.1038/s41586-021-03372-y
https://doi.org/10.1038/s41586-021-03372-y
Publikováno v:
Biochemical and Biophysical Research Communications. 534:141-148
Nuclear transporter Importin (Imp, Ipo) 13 is known to transport various mammalian cargoes into/out of the nucleus, but its role in directing cell-fate is unclear. Here we examine the role of Imp13 in the maintenance of pluripotency and differentiati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1174c28c97928cde694e9b68dbe74122
https://doi.org/10.1016/j.bbrc.2020.11.099
https://doi.org/10.1016/j.bbrc.2020.11.099
Autor:
Atefeh Namipashaki, Xiaodong Liu, Kealan Pugsley, Sue Mei Lim, Guizhi Sun, Marco J. Herold, Jose M. Polo, Mark A. Bellgrove, Ziarih Hawi
The capability to generate induced pluripotent cell (iPSC) lines, in combination with the CRISPR-Cas9 DNA editing technology, offers great promise to understand the underlying genetic mechanisms of human disease. However, technical impediments includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b256a6926398694a81e29a6e9a4ff1cf
https://doi.org/10.1101/2022.04.12.488094
https://doi.org/10.1101/2022.04.12.488094
Autor:
Cheng Huang, Jaber Firas, Partha Pratim Das, Yu Bo Yang Sun, Anja S Knaupp, Joseph Chen, Melissa L. Holmes, Christian M. Nefzger, Fernando J. Rossello, Pratibha Tripathi, Trung V. Nguyen, Ralf B. Schittenhelm, Sue Mei Lim, Kayla Wong, Xiaodong Liu, Monika Mohenska, Jody J. Haigh, Jan Schröder, Ryan Lister, Jahnvi Pflueger, Kathryn C. Davidson, Ethan Ford, Jose M. Polo, Michael R. Larcombe
Publikováno v:
Stem Cell Reports
Summary Cellular identity is ultimately dictated by the interaction of transcription factors with regulatory elements (REs) to control gene expression. Advances in epigenome profiling techniques have significantly increased our understanding of cell-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb069fae910ab47ceb5d6cea44adf7d
https://doi.org/10.1016/j.stemcr.2020.11.005
https://doi.org/10.1016/j.stemcr.2020.11.005
Autor:
Xiaodong, Liu, Jia Ping, Tan, Jan, Schröder, Asma, Aberkane, John F, Ouyang, Monika, Mohenska, Sue Mei, Lim, Yu B Y, Sun, Joseph, Chen, Guizhi, Sun, Yichen, Zhou, Daniel, Poppe, Ryan, Lister, Amander T, Clark, Owen J L, Rackham, Jennifer, Zenker, Jose M, Polo
Publikováno v:
Signal Transduction and Targeted Therapy
Human pluripotent and trophoblast stem cells have been essential alternatives to blastocysts for understanding early human development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0058ab8817229c8535f25784b845cff8
https://pubmed.ncbi.nlm.nih.gov/34135304
https://pubmed.ncbi.nlm.nih.gov/34135304
Autor:
Lisa A. Miosge, Grady C. Smith, Jenny Z. Song, Amanda Khoury, Shalima S. Nair, Sue Mei Lim, Ozren Bogdanovic, Clare Stirzaker, Qian Du, Ruth Pidsley, Tim J Peters, Christopher C. Goodnow, Etienne Masle-Farquhar, Ksenia Skvortsova, James G. Kench, Elena Zotenko, Wenjia Qu, Susan J. Clark, Phuc-Loi Luu, Mark A. Rubin, Cathryn M. Gould, Joanne H. Reed, Lisa G. Horvath, Jose M. Polo, Yolanda Colino-Sanguino
Promoter CpG islands are typically unmethylated in normal cells, but in cancer a proportion are subject to hypermethylation. Using methylome sequencing we identified CpG islands that display partial methylation encroachment across the 5' or 3' CpG is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c8f2dd8aaccb7fcfe5dfb6942f8fcd