Výsledky vyhledávání - "STZ, streptozotocin"

Akademický článek

Effect of Topical Gel Ethanol Extract of Gotu Kola Leaf (Centella Asiatica (L.) Urban) on Wound Healing in a White Male Rat (Rattus Norvegicus) Induced by Streptozotocin

Autor: I Dewa Ayu Sudiari Dewi, Nurmawati Fatimah, Sutji Kuswarini

Publikováno v: Surabaya Physical Medicine and Rehabilitation Journal, Vol 5, Iss 2, Pp 78-83 (2023)

Background: Diabetes mellitus (DM) can have a number of consequences, one of which is diabetic neuropathy, which can cause sores, notably in patients' feet. Wound therapy with synthetic drugs in diabetes is still not functioning as well as expected.

Externí odkaz: https://doaj.org/article/291df1c3e8544535bccb62c9452b0b37

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Akademický článek

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Spatial-resolved metabolomics reveals tissue-specific metabolic reprogramming in diabetic nephropathy by using mass spectrometry imaging

Autor: Lu Tian, Wanfang Li, Jinfeng Wei, Zhi Zhou, Yanhua Chen, Zhonghua Wang, Wenqing Fu, Yaqi Liu, Baili Wang, Bingshu He, Meiling Huo, Jianzhen Xia, Zeper Abliz

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 11, Pp 3665-3677 (2021)
Acta Pharmaceutica Sinica. B

Detailed knowledge on tissue-specific metabolic reprogramming in diabetic nephropathy (DN) is vital for more accurate understanding the molecular pathological signature and developing novel therapeutic strategies. In the present study, a spatial-reso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e36a0724bd8a167963aba4a72cb2332
http://www.sciencedirect.com/science/article/pii/S2211383521001799

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Facile synthesis of insulin fusion derivatives through sortase A ligation

Autor: Jinze Li, Maria M. Disotuar, Nai-Pin Lin, Jake A. Smith, Danny Hung-Chieh Chou, Steve L. Alam

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2719-2725 (2021)
Acta Pharmaceutica Sinica. B

Insulin derivatives such as insulin detemir and insulin degludec are U.S. Food and Drug Administration (FDA)-approved long-acting insulin currently used by millions of people with diabetes. These derivatives are modified in C-terminal B29 lysine to r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1984559319e185f56741a54626eb56
http://www.sciencedirect.com/science/article/pii/S2211383520308017

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Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management

Autor: Hai-Yong Chen, Yibin Feng, Cheng Zhang, Ning Wang, Sha Li, Guoyi Tang

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)

Diabetic nephropathy (DN) has been recognized as a severe complication of diabetes mellitus and a dominant pathogeny of end-stage kidney disease, which causes serious health problems and great financial burden to human society worldwide. Conventional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d8ab4193adc39b242fa3c089b4f517
https://doi.org/10.1016/j.apsb.2020.12.020

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A metabolomics approach to investigate the proceedings of mitochondrial dysfunction in rats from prediabetes to diabetes

Autor: Ming-Shi Shiao, Tso-Yen Mao, Mei-Ling Cheng, Ann Chen, Chun-Feng Huang, Siao-Yun Lin

Publikováno v: Saudi Journal of Biological Sciences, Vol 28, Iss 8, Pp 4762-4769 (2021)
Saudi Journal of Biological Sciences

Background Diabetes mellitus (DM) is a leading cause of preventable cardiovascular disease, but the metabolic changes from prediabetes to diabetes have not been fully clarified. This study implemented a metabolomics profiling platform to investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::712a8e3872aa86dc83a7a0157235d90d
http://www.sciencedirect.com/science/article/pii/S1319562X21003661

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Artemisia judaica L. diminishes diabetes-induced reproductive dysfunction in male rats via activation of Nrf2/HO-1-mediated antioxidant responses

Autor: Maged S. Abdel-Kader, Gamal A. Soliman, Ahmed I. Foudah, Abdulaziz S. Saeedan, Reham M. Abd-Elsalam, Hanan A. Ogaly, Rehab F. Abdel-Rahman

Publikováno v: Saudi Journal of Biological Sciences, Vol 28, Iss 3, Pp 1713-1722 (2021)
Saudi Journal of Biological Sciences

Graphical abstract
Diabetes mellitus is a well-known danger element for the progression of male reproductive dysfunctions. Available evidence supports oxidative stress to be the underlying mechanism for the manifestation of testicular dysfunctio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddef32683deddd75fdedb6dda4e14ed
http://www.sciencedirect.com/science/article/pii/S1319562X20306689

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Artemisinin and artemisinin derivatives as anti-fibrotic therapeutics

Autor: Tanja Dominko, Pamela J. Weathers, David Dolivo

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 322-339 (2021)
Acta Pharmaceutica Sinica. B

Fibrosis is a pathological reparative process that can occur in most organs and is responsible for nearly half of deaths in the developed world. Despite considerable research, few therapies have proven effective and been approved clinically for treat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31e277e49b3a3364e9726d531259ad4
https://doi.org/10.1016/j.apsb.2020.09.001

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The potential role of sesquiterpene lactones isolated from medicinal plants in the treatment of the metabolic syndrome – A review

Autor: Anuar Salazar-Gómez, Saudy Saret Pablo-Pérez, M. Elena Vargas-Dı́az, Julio C. Ontiveros-Rodríguez, Leticia Garduño-Siciliano

Publikováno v: South African Journal of Botany

Highlights • Definition and pathogenesis of metabolic syndrome is briefly described. • Sesquiterpene lactones isolated from medicinal plants used in traditional medicine. • In vivo and in vitro biological activities of sesquiterpene lactones ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512583e8aceec7a8d3995bc13c6d8a6c
https://doi.org/10.1016/j.sajb.2020.08.020

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Wound healing efficacy of Jamun honey in diabetic mice model through reepithelialization, collagen deposition and angiogenesis

Autor: Jyotirmoy Chatterjee, Swarnendu Bag, Amrita Chaudhary, Provas Banerjee

Publikováno v: Journal of Traditional and Complementary Medicine, Vol 10, Iss 6, Pp 529-543 (2020)
Journal of Traditional and Complementary Medicine

Diabetic patients are frequently afflicted with impaired wound healing where linear progression of molecular and cellular events compromised. Despite of meaningful progress in diabetic treatment, management of diabetic chronic wounds is still challen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa88f497fe0a9748bfca26f365e1bdf
http://www.sciencedirect.com/science/article/pii/S2225411019305577

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