Zobrazeno 1 - 10
of 2 591
pro vyhledávání: '"STZ"'
Publikováno v:
Shipin gongye ke-ji, Vol 45, Iss 19, Pp 357-365 (2024)
To explore the hypoglycemic effect of Moringa oleifera leaf polysaccharide (MOLP) on diabetic mice and its corresponding mechanism, a streptozotocin (STZ)-induced diabetic mouse was modeled. The mice were then divided into groups exposed to low (100
Externí odkaz:
https://doaj.org/article/12057ee9eefa4ca1b92bc15e89947c30
Autor:
Yu Lin, Wenyu Du, Xiangyu Fu, Ling Huang, Yiwen Hong, Haishan Tan, Lirong Xiao, Xiang Ren, Yujiao Wang, Danian Chen
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Chemicals, such as MNU (N-methyl-N-nitrosourea) and NaIO3 (sodium iodate), are widely used to induce retinal degeneration in rodents. Streptozotocin (STZ) is an analog of N-acetyl glucosamine in which an MNU moiety is linked to a hexose
Externí odkaz:
https://doaj.org/article/f9c6884e64cf48288dd933115734183a
Autor:
Radoslav Stojchevski, Sara Velichkovikj, Jane Bogdanov, Nikola Hadzi-Petrushev, Mitko Mladenov, Leonid Poretsky, Dimiter Avtanski
Publikováno v:
Data in Brief, Vol 57, Iss , Pp 110952- (2024)
This paper presents a dataset obtained from an RT2-qPCR array analysis of rat pancreatic RIN-m cells treated with two monocarbonyl analogs of curcumin (MACs), C66 and B2BrBC in the presence or absence of streptozotocin (STZ). The array quantified the
Externí odkaz:
https://doaj.org/article/a4be3db87d0e416ab86bd6a0c0e47547
Autor:
Uwe Grether, Richard H. Foxton, Sabine Gruener, Claudia Korn, Atsushi Kimbara, Anja Osterwald, Elisabeth Zirwes, Sabine Uhles, Janina Thoele, Nadine Colé, Mark Rogers-Evans, Stephan Röver, Matthias Nettekoven, Rainer E. Martin, Jean-Michel Adam, Jürgen Fingerle, Caterina Bissantz, Wolfgang Guba, André Alker, Anna M. Szczesniak, Ross F. Porter, Tom J. Toguri, Franco Revelant, Agnès Poirier, Camille Perret, Lotte Winther, Antonello Caruso, Filomena Fezza, Mauro Maccarrone, Melanie E. M. Kelly, Sascha Fauser, Christoph Ullmer
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionPreclinical studies suggest that cannabinoid receptor type 2 (CB2R) activation has a therapeutic effect in animal models on chronic inflammation and vascular permeability, which are key pathological features of diabetic retinopathy (DR).
Externí odkaz:
https://doaj.org/article/91d1c3e1c6e44284b2f5d719fd280ff1
Autor:
Joanna Godzien, Kacper Jablonowski, Francisco J. Ruperez, Adam Kretowski, Michal Ciborowski, Bartlomiej Kalaska
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116731- (2024)
Nutraceuticals have gained increasing interest, prompting the need to investigate plant extracts for their beneficial properties and potential side effects. This study aimed to assess the nutraceutical effects of environmentally clean extracts from R
Externí odkaz:
https://doaj.org/article/e49f6d936ac640009d3c21cb9d54f4c5
Publikováno v:
Pharmacological Research - Modern Chinese Medicine, Vol 11, Iss , Pp 100436- (2024)
Introduction: The objective of the study was to determine antidiabetic and antihyperlipidemic effects of Mangifera camptosperma leaves extract using streptozotocin-induced animal model. Methods: The leaves of M. camptosperma extracted with hydroethan
Externí odkaz:
https://doaj.org/article/b0f5dbc1fd564797a42188927fbd6bfc
Autor:
Martina Arici, Shih-Che Hsu, Mara Ferrandi, Paolo Barassi, Carlotta Ronchi, Eleonora Torre, Andrea Luraghi, Gwo-Jyh Chang, Patrizia Ferrari, Giuseppe Bianchi, Francesco Peri, Antonio Zaza, Marcella Rocchetti
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background The sarcoplasmic reticulum (SR) Ca2+ ATPase (SERCA2a) depression substantially contributes to diastolic dysfunction in heart failure (HF), suggesting that SERCA2a stimulation may be a mechanism-based HF therapy. Istaroxime is a dr
Externí odkaz:
https://doaj.org/article/782d6a7de41e442dbf9d2b9799220397
Publikováno v:
Laboratory Animal Research, Vol 39, Iss 1, Pp 1-18 (2023)
Abstract Alzheimer’s disease (AD) is a multifactorial, rapidly progressing neurodegenerative disorder. As the exact cause of the disease is still unclear, the drug development is very challenging. This review encompasses the commonly used AD models
Externí odkaz:
https://doaj.org/article/1578af354ef248d7abd0d728dd1b60d7
Autor:
Caiyan Qu, Xiyue Tan, Qichao Hu, Jiao Tang, Yangyang Wang, Caiying He, ZiJia He, Bin Li, Xiaoxu Fu, Quanyu Du
Publikováno v:
Heliyon, Vol 10, Iss 5, Pp e26863- (2024)
Context: Diabetes mellitus (DM) is one of the fastest-growing diseases worldwide; however, its pathogenesis remains unclear. Complications seriously affect the quality of life of patients in the later stages of diabetes, ultimately leading to sufferi
Externí odkaz:
https://doaj.org/article/63848276e6354c7ab9bb8cca57ef6e02
Autor:
Du Hyeon Hwang, Ravi Deva Asirvatham, Ramachandran Loganathan Mohan Prakash, Changkeun Kang, Euikyung Kim
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8944 (2024)
Rosa davurica Pall. is widely used in traditional oriental herbal therapy, but its components and molecular mechanisms of action remain unclear. This study investigates the antidiabetic potential of Rosa davurica Pall. root extract (RDR) and elucidat
Externí odkaz:
https://doaj.org/article/43c1f97e78bd4ef394fd674c4cbc1824