Zobrazeno 1 - 10
of 160
pro vyhledávání: '"STUbL"'
Autor:
Ya-Chu Chang, Kevin Lin, Ryan M. Baxley, Wesley Durrett, Liangjun Wang, Olivera Stojkova, Maximilian Billmann, Henry Ward, Chad L. Myers, Anja-Katrin Bielinsky
Publikováno v:
Open Biology, Vol 13, Iss 8 (2023)
DNA replication requires precise regulation achieved through post-translational modifications, including ubiquitination and SUMOylation. These modifications are linked by the SUMO-targeted E3 ubiquitin ligases (STUbLs). Ring finger protein 4 (RNF4),
Externí odkaz:
https://doaj.org/article/fc25571c38be441b9df006b8d49f3bfe
Akademický článek
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Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2020)
The dynamic and reversible post-translational modification of proteins and protein complexes with the ubiquitin-related SUMO modifier regulates a wide variety of nuclear functions, such as transcription, replication and DNA repair. SUMO can be attach
Externí odkaz:
https://doaj.org/article/4a7a2b8da90c45c8b5912f81b5aac158
Autor:
Jane J. Thomas, Mona Abed, Julian Heuberger, Rostislav Novak, Yaniv Zohar, Angela P. Beltran Lopez, Julie S. Trausch-Azar, Ma. Xenia G. Ilagan, David Benhamou, Gunnar Dittmar, Raphael Kopan, Walter Birchmeier, Alan L. Schwartz, Amir Orian
Publikováno v:
Cell Reports, Vol 16, Iss 12, Pp 3388-3400 (2016)
Ubiquitylation regulates signaling pathways critical for cancer development and, in many cases, targets proteins for degradation. Here, we report that ubiquitylation by RNF4 stabilizes otherwise short-lived oncogenic transcription factors, including
Externí odkaz:
https://doaj.org/article/d03b4a0af0244a48b43e395431f94d77
Akademický článek
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Autor:
Kentaro Ohkuni, Nagesh Pasupala, Jennifer Peek, Grace Lauren Holloway, Gloria D. Sclar, Reuben Levy-Myers, Richard E. Baker, Munira A. Basrai, Oliver Kerscher
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Cell viability and gene expression profiles are altered in cellular models of neurodegenerative disorders such as Huntington’s Disease (HD). Using the yeast model system, we show that the SUMO-targeted ubiquitin ligase (STUbL) Slx5 reduces the toxi
Externí odkaz:
https://doaj.org/article/3bc68a8c17d340b5ad33f25c6dff5792
Autor:
Wouter Boomsma, Sofie V. Nielsen, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen, Lars Ellgaard
Publikováno v:
PeerJ, Vol 4, p e1725 (2016)
The ubiquitin-proteasome system targets misfolded proteins for degradation. Since the accumulation of such proteins is potentially harmful for the cell, their prompt removal is important. E3 ubiquitin-protein ligases mediate substrate ubiquitination
Externí odkaz:
https://doaj.org/article/41b48fa6bddb4581aff2ec721d53926f
Publikováno v:
Cells, Vol 10, Iss 2374, p 2374 (2021)
Cells
Cells
A hallmark of cancer is dysregulated protein turnover (proteostasis), which involves pathologic ubiquitin-dependent degradation of tumor suppressor proteins, as well as increased oncoprotein stabilization. The latter is due, in part, to mutation with
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 5391, p 5391 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 5391, p 5391 (2021)
Small ubiquitin-like modifier (SUMO)-targeted E3 ubiquitin ligases (STUbLs) are specialized enzymes that recognize SUMOylated proteins and attach ubiquitin to them. They therefore connect the cellular SUMOylation and ubiquitination circuits. STUbLs p
Autor:
Dorison, Hugo
The repair of double-stranded DNA breaks (DSBs) by homologous recombination involves the formation of branched intermediates that can lead to crossovers following nucleolytic resolution. Ubiquitin and SUMO modification is commonplace amongst the DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______166::6b1f0fcc5fdfca23a87e2616fb6cc2ea
https://theses.hal.science/tel-03539739
https://theses.hal.science/tel-03539739