Výsledky vyhledávání - "STK11 (LKB1)"

Akademický článek

LKB1: Can We Target an Hidden Target? Focus on NSCLC

Autor: Gloriana Ndembe, Ilenia Intini, Elisa Perin, Mirko Marabese, Elisa Caiola, Paolo Mendogni, Lorenzo Rosso, Massimo Broggini, Marika Colombo

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

LKB1 (liver kinase B1) is a master regulator of several processes such as metabolism, proliferation, cell polarity and immunity. About one third of non-small cell lung cancers (NSCLCs) present LKB1 alterations, which almost invariably lead to protein

Externí odkaz: https://doaj.org/article/8433b15eaf0046ca8d4f118ed1971f7a

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Akademický článek

Loss of cellular identity in common pre-clinical models of serine‑threonine kinase 11 (Liver kinase B1) loss

Autor: Santhosh Kumar Karthikeyan, Nicholas T. Gimbrone, Trent R. Percy, W. Douglas Cress

Publikováno v: Cancer Treatment and Research Communications, Vol 26, Iss , Pp 100286- (2021)

Nearly 1/3 of lung adenocarcinomas have loss of STK11 (LKB1) function. Herein, a bioinformatics approach was used to determine how accurately preclinical model systems reflect the in vivo biology of STK11 loss in human patients. Hierarchical and K-me

Externí odkaz: https://doaj.org/article/17c643c669f1423abf673c0fc72bf696

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Role of next generation sequencing-based liquid biopsy in advanced non-small cell lung cancer patients treated with immune checkpoint inhibitors: impact of STK11, KRAS and TP53 mutations and co-mutations on outcome

Autor: Alessandro Dal Maso, Andrea Boscolo Bragadin, Giuseppe Aprile, Stefano Frega, Valentina Guarneri, Matteo Fassan, Pierfranco Conte, Elisabetta Zulato, Andrea Giovanni Menin, Lorenzo Calvetti, Fiorella Calabrese, Giulia Pasello, Alberto Pavan, Ilaria Attili, Laura Bonanno, Rafael Rosell, Alessandra Ferro, Giorgia Nardo, Stefano Indraccolo

Publikováno v: Transl Lung Cancer Res
Translational Lung Cancer Research
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
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Background: Characterization of tumor-related genetic alterations is promising for the screening of new predictive markers in non-small cell lung cancer (NSCLC). Aim of the study was to evaluate prognostic and predictive role of most frequent tumor-a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d74f037b177ea6956c0e0a6209e348
http://hdl.handle.net/11577/3371910

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STK11 Prevents Invasion Through STAT3/5 and FAK Repression in Cutaneous Melanoma

Autor: Dzung, Andreas, Saltari, Annalisa, Tiso, Natascia, Lyck, Ruth, Dummer, Reinhard, Levesque, Mitchell P

Publikováno v: Dzung, Andreas; Saltari, Annalisa; Tiso, Natascia; Lyck, Ruth; Dummer, Reinhard; Levesque, Mitchell P (2022). STK11 Prevents Invasion Through STAT3/5 and FAK Repression in Cutaneous Melanoma. Journal of investigative dermatology, 142(4), 1171-1182.e10. Elsevier 10.1016/j.jid.2021.09.035

The serine/threonine kinase 11 (STK11/LKB1) is a tumor suppressor involved in metabolism and cell motility. In BRAFV600E melanoma, STK11 is inactivated by ERK and RSK, preventing it from binding and activating AMPK and promoting melanoma cell prolife

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415598b98bcf640375faf748019e79a3
http://hdl.handle.net/11577/3405054

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