Zobrazeno 1 - 10
of 1 524
pro vyhledávání: '"STK11"'
Publikováno v:
Опухоли женской репродуктивной системы, Vol 20, Iss 2, Pp 74-82 (2024)
This article provides a review of studies analyzing the etiology, diagnosis, and treatment of Peitz–Jeghers syndrome, as well as the risk of cancer of different locations in patients with this genetic disorder. We report a case of Peitz–Jeghers s
Externí odkaz:
https://doaj.org/article/69f13b810bb4428983d564902c563e51
Publikováno v:
World Journal of Surgical Oncology, Vol 22, Iss 1, Pp 1-7 (2024)
Abstract Background Peutz–Jeghers syndrome (PJS), a rare dominantly inherited disease, is primarily characterized by hamartomatous polyps and melanotic macules as well as by an increased risk of cancer. The current study aimed to identify the patho
Externí odkaz:
https://doaj.org/article/d723b20cea29449c91f955c08673a09b
Publikováno v:
BMC Women's Health, Vol 24, Iss 1, Pp 1-7 (2024)
Abstract Background Peutz-Jeghers syndrome (PJS) is characterized by the presence of hamartomatous polyps in the gastrointestinal tract and mucocutaneous pigmentation on the lips, oral mucosa, nose, fingers, and toes. Synchronous mucinous metaplasia
Externí odkaz:
https://doaj.org/article/fbee8022bd064f4199f0f9206acaad3e
Autor:
Armin Frille, Myriam Boeschen, Hubert Wirtz, Mathias Stiller, Hendrik Bläker, Maximilian von Laffert
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Externí odkaz:
https://doaj.org/article/7ef651bacaff48dca8762017b9171dea
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background This study aimed to systematically analyze the effect of a serine/threonine kinase (STK11) mutation (STK11mut) on therapeutic efficacy and prognosis in patients with non-small cell lung cancer (NSCLC). Methods Candidate articles w
Externí odkaz:
https://doaj.org/article/c9502a3b6b07485a8d1cfedee9187d76
Publikováno v:
Gynecologic Oncology Reports, Vol 56, Iss , Pp 101521- (2024)
STK11 germline pathogenic variants are typically associated with Peutz-Jeghers syndrome, an autosomal dominant disease characterized by hamartomatous polyps in the gastrointestinal tract, hyperpigmented patches, and increased risk of stomach, colorec
Externí odkaz:
https://doaj.org/article/7c9ad546757b4f3caeb0b60173569f69
Publikováno v:
Open Medicine, Vol 19, Iss 1, Pp 209-49 (2024)
Serine/threonine kinase 11 (STK11), a tumor suppressor gene, exhibits frequent mutations in lung adenocarcinoma (LUAD). However, the specific molecular mechanisms by which STK11 mutations exert an influence on the biosynthesis of monounsaturated fatt
Externí odkaz:
https://doaj.org/article/b84100ac8f554a09b48b8758135d62fc
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundMutations in STK11 (STK11Mut) gene may present a negative impact on survival in Non-small Cell Lung Cancer (NSCLC) patients, however, its relationship with immune related genes remains unclear. This study is to unveil whether overexpressed-
Externí odkaz:
https://doaj.org/article/dafbd08daaa149c088ad8864539b1b76
Autor:
Armin Frille, Myriam Boeschen, Hubert Wirtz, Mathias Stiller, Hendrik Bläker, Maximilian von Laffert
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundRecently, we could show that the co-mutations of KRAS + KEAP1, STK11 + KEAP1 and KRAS + STK11 + KEAP1 lead to a significantly shorter median overall survival (mOS) in patients with lung cancer across treatments by analyzing multiple dataset
Externí odkaz:
https://doaj.org/article/a3158136e83046d5a3cff5f8e1ece06f
Autor:
Tatiana S. Belysheva, Tatiana V. Nasedkina, Timur T. Valiev, Elena V. Sharapova, Vera V. Semenova, Valentina M. Kozlova, Svetlana N. Mikhaylova, Irina S. Kletskaya, Alexey V. Butuzov, Yana V. Vishnevskaja, Valeria V. Lozovaya, Olga A. Gusarova, Armen O. Tumanyan, Olga A. Malichova, Svetlana R. Varfolomeeva
Publikováno v:
Вопросы современной педиатрии, Vol 22, Iss 4, Pp 331-342 (2023)
Background. Hereditary polyposis syndromes (HPS) are a group of rare genetic diseases characterized by multiple epithelial lesions in the gastrointestinal tract (GIT) with high risk of malignancy and neoplasia development in other localizations. The
Externí odkaz:
https://doaj.org/article/011e6e7a0dea4c1fbb5c37943a6d301f