Výsledky vyhledávání - "STEVEN BROSTOFF"

Selection ofhprtMutant T Cells as Surrogates for Dividing Cells Reveals a Restricted T Cell Receptor BV Repertoire in Insulin-Dependent Diabetes Mellitus

Autor: Gregory K. Magin, Lawrence Steinman, Steven Brostoff, Mark A. Atkinson, Mark Allegretta, Michael T. Falta, Richard J. Albertini

Publikováno v: Clinical Immunology. 90:340-351

T cells with somatically acquired mutations in the hypoxanthine-guanine phosphoribosyltransferase (hprt) gene were isolated from patients with insulin-dependent diabetes mellitus (IDDM) as representatives of populations potentially enriched for in vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a43cf67c0d1a80199e0fce74b66a059
https://doi.org/10.1006/clim.1998.4664

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The Development and Use of T Cell Receptor Peptide Vaccines

Autor: Steven Brostoff

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9781461357711

Autoreactivity is a normal feature of the immune system which must be able to distinguish self from non-self. However, when this autoreactivity results in pathological tissue damage, autoimmune diseases result. While autoimmune diseases can be associ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70a7550b05cc6b049753bf4bcaf77ff1
https://doi.org/10.1007/978-1-4615-1891-4_26

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Homologies between T cell receptor junctional sequences unique to multiple sclerosis and T cells mediating experimental allergic encephalomyelitis

Autor: Lawrence Steinman, Mark D. Howell, Mark Allegretta, Lawrence R. Smith, Henry F. McFarland, Richard J. Albertini, Roland Martin, Steven Brostoff, Subramamiam Sriram

Publikováno v: The Journal of clinical investigation. 94(1)

The selection of T cell clones with mutations in the hypoxanthine guanine phosphoribosyltransferase (hprt) gene has been used to isolate T cells reactive to myelin basic protein (MBP) in patients with multiple sclerosis (MS). These T cell clones are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c217d000eb39e2150937b8b77bbcc59a
https://pubmed.ncbi.nlm.nih.gov/8040252

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Characterization of rat encephalitogenic T cells bearing non-V beta 8 T cell receptors

Autor: Deming Sun, Daniel P. Gold, Lawrence R. Smith, Steven Brostoff, Christopher Coleclough

Publikováno v: European journal of immunology. 22(2)

In this study, we demonstrate that T cell lines specific for a synthetic peptide representing sequence 87 to 99 of myelin basic protein (MBP) are encephalitogenic in Lewis rats. However, unlike syngeneic T cells specific for MBP residues 68 to 88 whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ccd7e9a760398a4fe55a9136cc28482
https://pubmed.ncbi.nlm.nih.gov/1371473

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Basic A1 Protein of the Myelin Membrane

Autor: George A. Hashim, Paul R. Burnett, Steven Brostoff, Juanita Caccam, E.H. Eylar

Publikováno v: Journal of Biological Chemistry. 246:5770-5784

Twenty-seven tryptic peptides were isolated from the A1 protein from bovine spinal cord. These, together with 16 peptic peptides, were utilized to establish the complete amino acid sequence of the 170 residues of the A1 protein. Peptide T, derived fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6759b48da00b5d41b85d5550fcb5eb0f
https://doi.org/10.1016/s0021-9258(18)61872-1

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Allergic Encephalomyelitis

Autor: E.H. Eylar, Fred C. Westall, Steven Brostoff

Publikováno v: Journal of Biological Chemistry. 246:3418-3424

A peptide (Peptide R) of 46 residues was isolated in unusually high yield (40 to 85%) from a peptic digest of the A1 protein, a basic protein from bovine myelin of the central nervous system. This peptide (4990 daltons) induced experimental allergic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7557033341e7ba3dcc46f27b3bff6953
https://doi.org/10.1016/s0021-9258(18)62240-9

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Recurrent experimental allergic polyganglioradiculoneuritis. Multiple demyelinating episodes in rhesus monkey sensitized with rabbit sciatic nerve myelin

Autor: Harry Carter, Steven Brostoff, Henryk M. Wiśniewski, E. H. Eylar

Publikováno v: Archives of neurology. 30(5)

Seven rhesus monkeys immunized with 60 to 70 mg of rabbit sciatic nerve myelin developed neurological symptoms (ptosis, strabismus, paresis, or paralysis). In two animals clinical episodes of the disease recurred. Morphologic studies of the animals b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a12065ecc8be64771471b4fbb59f25
https://pubmed.ncbi.nlm.nih.gov/4207010

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