Zobrazeno 1 - 10
of 103
pro vyhledávání: '"STEVE A.N. GOLDSTEIN"'
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105901- (2023)
Summary: There are no targeted medical therapies for Acute Lung Injury (ALI) or its most severe form acute respiratory distress syndrome (ARDS). Infections are the most common cause of ALI/ARDS and these disorders present clinically with alveolar inf
Externí odkaz:
https://doaj.org/article/67f2bd13e9d649ec975e77528947ce40
Publikováno v:
Cell Reports, Vol 30, Iss 7, Pp 2225-2236.e4 (2020)
Summary: Acute cardiac hypoxia produces life-threatening elevations in late sodium current (ILATE) in the human heart. Here, we show the underlying mechanism: hypoxia induces rapid SUMOylation of NaV1.5 channels so they reopen when normally inactive,
Externí odkaz:
https://doaj.org/article/153af7352f2d4e398ac2f2b643dd0b3a
Autor:
Francisco Sepúlveda, Leigh D. Plant, Daniel L. Minor, Jr., Florian Lesage, Steve A.N. Goldstein, Péter Enyedi, Gábor Czirják, Douglas A. Bayliss, Austin M. Baggetta
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
The 4TM family of K channels mediate many of the background potassium currents observed in native cells. They are open across the physiological voltage-range and are regulated by a wide array of neurotransmitters and biochemical mediators. The pore-f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea7fde47c570d550bb1c3c79a91764bb
https://doi.org/10.2218/gtopdb/f79/2023.1
https://doi.org/10.2218/gtopdb/f79/2023.1
Autor:
Rían W. Manville, Luis G. Cuello, Anthony Lewis, Steve A.N. Goldstein, M Oana Popa, Zoe A. McCrossan
Publikováno v:
Lewis, A, McCrossan, Z A, Manville, R, Popa, O, Cuello, L & Goldstein, S 2020, ' TOK channels use the two gates in classical K + channels to achieve outward rectification ', FASEB Journal, vol. 34, no. 7, 0, pp. 8902-8919 . https://doi.org/10.1096/fj.202000545R
TOKs are outwardly rectifying K+ channels in fungi with two pore-loops and eight transmembrane spans. Here, we describe the TOKs from four pathogens that cause the majority of life-threatening fungal infections in humans. These TOKs pass large curren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbb2072bbd4afdb401fa74fdbe09f6a
https://doi.org/10.1096/fj.202000545r
https://doi.org/10.1096/fj.202000545r
Autor:
Chandy George, Israel Hanukoglu, Aguan D. Wei, Jane F. Armstrong, John A. Peters, Roslyn M. Bill, Steve A.N. Goldstein, Lucia G. Sivilotti, Mootaz M. Salman, Heike Wulff, Paul Davies, Michael Zhu, Stephan Kellenberger, Elena Faccenda, Michael F. Jarvis, Dejian Ren, Stefanie Fenske, Emma L. Veale, Jörg Striessnig, Verena Hammelmann, Brian F. King, Terrance P. Snutch, Trevor G. Smart, Leonard K. Kaczmarek, Brenda T. Winn, Eamonn Kelly, Philip Kitchen, Richard W. Aldrich, Jamie A. Davies, Charlotte Van den Eynde, Lachlan D. Rash, Edward Perez-Reyes, Elvir Becirovic, Christopher Southan, Joris Vriens, William A. Catterall, Jinbin Tian, Martin Biel, Adam J. Pawson, Leigh D. Plant, Alistair Mathie, Kotdaji Ha, James S. Trimmer, Bernard Attali, Anders A. Jensen, Lixia Yue, Joseph W. Lynch, Austin M. Baggetta, Haoxing Xu, Charles Kennedy, Xiaoli Zhang, Stephen P.H. Alexander, Simon D. Harding, Markus Delling, Simonetta Falzoni, Stephan Grissmer, Francesco Di Virgilio, Alex C. Conner
Publikováno v:
British journal of pharmacology, vol. 178 Suppl 1, pp. S157-S245
Alexander, S P, Mathie, A, Peters, J A, Veale, E L, Striessnig, J, Kelly, E, Armstrong, J F, Faccenda, E, Harding, S D, Pawson, A J, Southan, C, Davies, J A, Aldrich, R W, Attali, B, Baggetta, A M, Becirovic, E, Biel, M, Bill, R M, Catterall, W A, Conner, A C, Davies, P, Delling, M, Virgilio, F D, Falzoni, S, Fenske, S, George, C, Goldstein, S A N, Grissmer, S, Ha, K, Hammelmann, V, Hanukoglu, I, Jarvis, M, Jensen, A A, Kaczmarek, L K, Kellenberger, S, Kennedy, C, King, B, Kitchen, P, Lynch, J W, Perez-Reyes, E, Plant, L D, Rash, L, Ren, D, Salman, M M, Sivilotti, L G, Smart, T G, Snutch, T P, Tian, J, Trimmer, J S, Van den Eynde, C, Vriens, J, Wei, A D, Winn, B T, Wulff, H, Xu, H, Yue, L, Zhang, X & Zhu, M 2021, ' The concise guide to pharmacology 2021/22 : Ion channels ', British Journal of Pharmacology, vol. 178, no. Suppl. 1, pp. S157-S245 . https://doi.org/10.1111/bph.15539
Alexander, S P, Mathie, A, Peters, J A, Veale, E L, Striessnig, J, Kelly, E, Armstrong, J F, Faccenda, E, Harding, S D, Pawson, A J, Southan, C, Davies, J A, Aldrich, R W, Attali, B, Baggetta, A M, Becirovic, E, Biel, M, Bill, R M, Catterall, W A, Conner, A C, Davies, P, Delling, M, Virgilio, F D, Falzoni, S, Fenske, S, George, C, Goldstein, S A N, Grissmer, S, Ha, K, Hammelmann, V, Hanukoglu, I, Jarvis, M, Jensen, A A, Kaczmarek, L K, Kellenberger, S, Kennedy, C, King, B, Kitchen, P, Lynch, J W, Perez-Reyes, E, Plant, L D, Rash, L, Ren, D, Salman, M M, Sivilotti, L G, Smart, T G, Snutch, T P, Tian, J, Trimmer, J S, Van den Eynde, C, Vriens, J, Wei, A D, Winn, B T, Wulff, H, Xu, H, Yue, L, Zhang, X & Zhu, M 2021, ' The concise guide to pharmacology 2021/22 : Ion channels ', British Journal of Pharmacology, vol. 178, no. Suppl. 1, pp. S157-S245 . https://doi.org/10.1111/bph.15539
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d921561f4575efc693e15cc0f59fd20
https://serval.unil.ch/resource/serval:BIB_8F1855C9FD25.P001/REF.pdf
https://serval.unil.ch/resource/serval:BIB_8F1855C9FD25.P001/REF.pdf
Autor:
Francisco V. Sepúlveda, Daniel L. Minor, Austin M. Baggetta, Leigh D. Plant, Péter Enyedi, Douglas A. Bayliss, Steve A.N. Goldstein, Gábor Á. Czirják, Florian Lesage
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2021
The 4TM family of K channels mediate many of the background potassium currents observed in native cells. They are open across the physiological voltage-range and are regulated by a wide array of neurotransmitters and biochemical mediators. The pore-f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28942ae62e0baa769815302d8543f6fe
https://doi.org/10.2218/gtopdb/f79/2021.3
https://doi.org/10.2218/gtopdb/f79/2021.3
Autor:
Daniel L. Minor, Péter Enyedi, Leigh D. Plant, Austin M. Baggetta, Gábor Á. Czirják, Douglas A. Bayliss, Steve A.N. Goldstein, Florian Lesage, Francisco V. Sepúlveda, Brenda T. Winn
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2021
The 4TM family of K channels mediate many of the background potassium currents observed in native cells. They are open across the physiological voltage-range and are regulated by a wide array of neurotransmitters and biochemical mediators. The pore-f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ad5a124959d221787541e4dcc1dfdc2
https://doi.org/10.2218/gtopdb/f79/2021.2
https://doi.org/10.2218/gtopdb/f79/2021.2
Autor:
Eduardo Perozo, Martin Alejandro Pavarotti, Gerardo A. De Blas, Gerardo Orta, Alberto Darszon, Luis S. Mayorga, Rodolfo J. Arias, Steve A.N. Goldstein, Rong Shen, Hui Dai, Ruiming Zhao
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature communications, vol 12, iss 1
Human voltage-gated proton channels (hHv1) extrude protons from cells to compensate for charge and osmotic imbalances due metabolism, normalizing intracellular pH and regulating protein function. Human albumin (Alb), present at various levels through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43788f57e3f683ca191725bba4338617
https://doi.org/10.1038/s41467-021-24145-1
https://doi.org/10.1038/s41467-021-24145-1
Autor:
Ruiming Zhao, Steve A.N. Goldstein
Publikováno v:
Methods in Enzymology ISBN: 9780128239247
In this method paper, we describe protocols for using membrane-tethered peptide toxins (T-toxins) to study the structure/function and biophysics of toxin-channel interactions with two-electrode voltage clamp (TEVC). Here, we show how T-toxins can be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c08dacde526e1c1d6a0085fb8e072ba2
https://doi.org/10.1016/bs.mie.2021.03.002
https://doi.org/10.1016/bs.mie.2021.03.002
Autor:
Steve A.N. Goldstein
Publikováno v:
EMBO Molecular Medicine
In this issue of EMBO Molecular Medicine , Decher et al ([2017][1]) identify a point mutation in the K2P2 (TREK‐1) potassium (K+) channel that changes function in just those ways expected to predispose to right ventricular outflow tract (RVOT) vent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e371aefb4428854895d105183364da46
http://europepmc.org/articles/PMC5376743
http://europepmc.org/articles/PMC5376743