Zobrazeno 1 - 10
of 1 153
pro vyhledávání: '"STEPHEN J. LIPPARD"'
Autor:
Yi Wen Kong, Erik C. Dreaden, Sandra Morandell, Wen Zhou, Sanjeev S. Dhara, Ganapathy Sriram, Fred C. Lam, Jesse C. Patterson, Mohiuddin Quadir, Anh Dinh, Kevin E. Shopsowitz, Shohreh Varmeh, Ömer H. Yilmaz, Stephen J. Lippard, H. Christian Reinhardt, Michael T. Hemann, Paula T. Hammond, Michael B. Yaffe
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Cell cycle checkpoint kinase, MK2, is in synthetic relationship with p53 in the DNA damage response to chemotherapeutic agents. Here, the authors report XPA as a third gene in which simultaneous targeting of MK2 and XPA further enhances sensitivity t
Externí odkaz:
https://doaj.org/article/968af14e7f93410d8098ad17f0bc993d
Autor:
Ali Barandov, Benjamin B. Bartelle, Catherine G. Williamson, Emily S. Loucks, Stephen J. Lippard, Alan Jasanoff
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
There are only few MRI-compatible calcium reporters and they are limited to measuring extracellular calcium levels. Here the authors develop and validate a cell-permeable, manganese-based paramagnetic MRI contrast agent that enables monitoring intrac
Externí odkaz:
https://doaj.org/article/e5faf82e358e48b88a58d6f635d5f18c
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Abstract Small-molecule fluorescent probes are powerful and ubiquitous tools for measuring the concentration and distribution of analytes in living cells. However, accurate characterization of these analytes requires rigorous evaluation of cell-to-ce
Externí odkaz:
https://doaj.org/article/852635636b5e4591bccbb61e1037cb31
Autor:
Anna Hucke, Ga Young Park, Oliver B. Bauer, Georg Beyer, Christina Köppen, Dorothea Zeeh, Christoph A. Wehe, Michael Sperling, Rita Schröter, Marta Kantauskaitè, Yohannes Hagos, Uwe Karst, Stephen J. Lippard, Giuliano Ciarimboli
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
Cancer treatment with platinum compounds is an important achievement of modern chemotherapy. However, despite the beneficial effects, the clinical impact of these agents is hampered by the development of drug resistance as well as dose-limiting side
Externí odkaz:
https://doaj.org/article/a08b11d276134b76b82f7a8c9f729f2d
Autor:
Tamara Perez-Rosello, Charles T. Anderson, Cindy Ling, Stephen J. Lippard, Thanos Tzounopoulos
Publikováno v:
Neurobiology of Disease, Vol 81, Iss , Pp 14-19 (2015)
In many synapses of the CNS, mobile zinc is packaged into glutamatergic vesicles and co-released with glutamate during neurotransmission. Following synaptic release, the mobilized zinc modulates ligand- and voltage-gated channels and receptors, funct
Externí odkaz:
https://doaj.org/article/ede5f4b680c1474db5a175ef8e379c3c
Autor:
Stephen J. Lippard, Eric Raymond, Sandrine Faivre, Esteban Cvitkovic, Christian Gespach, Eugenio Erba, Massimo Broggini, Maurizio D'Incalci, Shahin Emami, Ivan Bieche, Maria Serova, Katherine S. Lovejoy
Pyriplatin, cis-diammine(pyridine)chloroplatinum(II), a platinum-based antitumor drug candidate, is a cationic compound with anticancer properties in mice and is a substrate for organic cation transporters that facilitate oxaliplatin uptake. Unlike c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a7ec47b3e1bba4fab6a6c0775215cb
https://doi.org/10.1158/1535-7163.c.6535264
https://doi.org/10.1158/1535-7163.c.6535264
Autor:
Zdravka Medarova, Stephen J. Lippard, Anna Moore, Seok-Hyun Yun, Xiao-an Zhang, Pilhan Kim, Subrata K. Ghosh
Supplementary Movie 2 from A Novel Imaging Approach for Early Detection of Prostate Cancer Based on Endogenous Zinc Sensing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f946414cc9fe8ef91668f83a85bf28d
https://doi.org/10.1158/0008-5472.22381925
https://doi.org/10.1158/0008-5472.22381925
Autor:
Kathleen M. Giacomini, Stephen J. Lippard, Xin Chen, Joe W. Gray, Takafumi Komori, Ying Chen, Anna Lapuk, Yan Shu, Leah L. Lagpacan, James E. Shima, Katherine S. Lovejoy, Shuzhong Zhang
Although the platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin have similar DNA-binding properties, only oxaliplatin is active against colorectal tumors. The mechanisms for this tumor specificity of platinum-based compounds are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc12a447e6712d143b4af76723b2a50d
https://doi.org/10.1158/0008-5472.c.6494126
https://doi.org/10.1158/0008-5472.c.6494126
Autor:
Zdravka Medarova, Stephen J. Lippard, Anna Moore, Seok-Hyun Yun, Xiao-an Zhang, Pilhan Kim, Subrata K. Ghosh
The early detection of prostate cancer is a life-saving event in patients harboring potentially aggressive disease. With the development of malignancy, there is a dramatic reduction in the zinc content of prostate tissue associated with the inability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5b955470c3fc58a79cbedf15b9e5c74
https://doi.org/10.1158/0008-5472.c.6500033.v1
https://doi.org/10.1158/0008-5472.c.6500033.v1
Autor:
Zdravka Medarova, Stephen J. Lippard, Anna Moore, Seok-Hyun Yun, Xiao-an Zhang, Pilhan Kim, Subrata K. Ghosh
Supplementary Materials, Figure Legends 1-3, Movie Legends 1-4 from A Novel Imaging Approach for Early Detection of Prostate Cancer Based on Endogenous Zinc Sensing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c93d09f33196be311c4ca29eea686d
https://doi.org/10.1158/0008-5472.22381931.v1
https://doi.org/10.1158/0008-5472.22381931.v1