Zobrazeno 1 - 10
of 86
pro vyhledávání: '"STEPHEN J. CLARK"'
Autor:
Marc Jan Bonder, Stephen J. Clark, Felix Krueger, Siyuan Luo, João Agostinho de Sousa, Aida M. Hashtroud, Thomas M. Stubbs, Anne-Katrien Stark, Steffen Rulands, Oliver Stegle, Wolf Reik, Ferdinand von Meyenn
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Ageing is the accumulation of changes and decline of function of organisms over time. The concept and biomarkers of biological age have been established, notably DNA methylation-based clocks. The emergence of single-cell DNA methylation prof
Externí odkaz:
https://doaj.org/article/ad7a8eed3efe49fdb4a325112b626eb9
Autor:
Pranay Shah, Ross Hill, Camille Dion, Stephen J. Clark, Abdulkadir Abakir, Jeroen Willems, Mark J. Arends, Juan I. Garaycoechea, Harry G. Leitch, Wolf Reik, Gerry P. Crossan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Mutations in DNA damage response (DDR) factors are associated with human infertility, which affects up to 15% of the population. The DDR is required during germ cell development and meiosis. One pathway implicated in human fertility is DNA t
Externí odkaz:
https://doaj.org/article/9298bed0fab347d4ab08101e4f2d4f6c
Autor:
Stephen J. Clark, Ricard Argelaguet, Tim Lohoff, Felix Krueger, Deborah Drage, Berthold Göttgens, John C. Marioni, Jennifer Nichols, Wolf Reik
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-20 (2022)
Abstract Background Perturbation of DNA methyltransferases (DNMTs) and of the active DNA demethylation pathway via ten-eleven translocation (TET) methylcytosine dioxygenases results in severe developmental defects and embryonic lethality. Dynamic con
Externí odkaz:
https://doaj.org/article/b2195c14571047cdb9fd7debc8032fd3
Autor:
Javier Rodríguez-Ubreva, Anna Arutyunyan, Marc Jan Bonder, Lucía Del Pino-Molina, Stephen J. Clark, Carlos de la Calle-Fabregat, Luz Garcia-Alonso, Louis-François Handfield, Laura Ciudad, Eduardo Andrés-León, Felix Krueger, Francesc Català-Moll, Virginia C. Rodríguez-Cortez, Krzysztof Polanski, Lira Mamanova, Stijn van Dongen, Vladimir Yu. Kiselev, María T. Martínez-Saavedra, Holger Heyn, Javier Martín, Klaus Warnatz, Eduardo López-Granados, Carlos Rodríguez-Gallego, Oliver Stegle, Gavin Kelsey, Roser Vento-Tormo, Esteban Ballestar
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Common variable immunodeficiency (CVID) is the most prevalent primary immunodeficiency. Here the authors perform single-cell omics analyses in CVID-discordant monozygotic twins and show epigenetic and transcriptional alterations associated with activ
Externí odkaz:
https://doaj.org/article/756d963f7c144359bcee7edece23814e
Publikováno v:
eLife, Vol 12 (2023)
The gill skeleton of cartilaginous fishes (sharks, skates, rays, and holocephalans) exhibits a striking anterior–posterior polarity, with a series of fine appendages called branchial rays projecting from the posterior margin of the gill arch cartil
Externí odkaz:
https://doaj.org/article/22c823db5b0b43f49533a446e17d58eb
Autor:
Tore Bleckwehl, Giuliano Crispatzu, Kaitlin Schaaf, Patricia Respuela, Michaela Bartusel, Laura Benson, Stephen J. Clark, Kristel M. Dorighi, Antonio Barral, Magdalena Laugsch, Wilfred F. J. van IJcken, Miguel Manzanares, Joanna Wysocka, Wolf Reik, Álvaro Rada-Iglesias
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
While inductive signals controlling germline specification are well characterized, the intrinsic factors that allow epiblast cells to respond to such signals remain largely unknown. Here the authors use in vitro differentiated primordial germ cells t
Externí odkaz:
https://doaj.org/article/bf07c5a2a44549a9aca337c37d7cef97
Autor:
Stephanie M. Linker, Lara Urban, Stephen J. Clark, Mariya Chhatriwala, Shradha Amatya, Davis J. McCarthy, Ingo Ebersberger, Ludovic Vallier, Wolf Reik, Oliver Stegle, Marc Jan Bonder
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-14 (2019)
Abstract Background Alternative splicing is a key regulatory mechanism in eukaryotic cells and increases the effective number of functionally distinct gene products. Using bulk RNA sequencing, splicing variation has been studied across human tissues
Externí odkaz:
https://doaj.org/article/3f09f95969f040e99c06b8d8c16ba604
Autor:
Stephen J. Clark, Ricard Argelaguet, Chantriolnt-Andreas Kapourani, Thomas M. Stubbs, Heather J. Lee, Celia Alda-Catalinas, Felix Krueger, Guido Sanguinetti, Gavin Kelsey, John C. Marioni, Oliver Stegle, Wolf Reik
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Relationships between DNA methylation and transcription, and methylation and DNA accessibility can be probed but interrogating all three in the same single cells has not been possible. Here, the authors report the first single-cell method for paralle
Externí odkaz:
https://doaj.org/article/ee5160af085446eb92ec31544e77c471
Autor:
Marc Jan Bonder, Stephen J. Clark, Felix Krueger, Siyuan Luo, João Agostinho de Sousa, Aida M. Hashtroud, Thomas M. Stubbs, Anne-Katrien Stark, Steffen Rulands, Oliver Stegle, Wolf Reik, Ferdinand von Meyenn
Ageing is the accumulation of changes and overall decline of the function of cells, organs and organisms over time. At the molecular and cellular level, the concept of biological age has been established and biomarkers of biological age have been ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed32a68303594e5d40c18bfb5708c8bf
https://doi.org/10.1101/2023.01.30.526343
https://doi.org/10.1101/2023.01.30.526343
