Zobrazeno 1 - 10
of 89
pro vyhledávání: '"STEPHEN G. CHANEY"'
Autor:
Debadeep Bhattacharyya, Srinivas Ramachandran, Shantanu Sharma, Wimal Pathmasiri, Candice L King, Irene Baskerville-Abraham, Gunnar Boysen, James A Swenberg, Sharon L Campbell, Nikolay V Dokholyan, Stephen G Chaney
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23582 (2011)
The differences in efficacy and molecular mechanisms of platinum anti-cancer drugs cisplatin (CP) and oxaliplatin (OX) are thought to be partially due to the differences in the DNA conformations of the CP and OX adducts that form on adjacent guanines
Externí odkaz:
https://doaj.org/article/9d8f7dd74edf4b36902921c80306d10b
Autor:
Gunnar Boysen, Kathryn E. deKrafft, Stephen G. Chaney, James A. Swenberg, Irene Baskerville-Abraham, Esra Mutlu, Wenbin Lin, J. Mitchell Troutman, Leonard B. Collins, Candice King
Publikováno v:
Chemical Research in Toxicology. 22:905-912
Platinum chemotherapeutic agents have been widely used in the treatment of cancer. Cisplatin was the first of the platinum-based chemotherapeutic agents and therefore has been extensively studied as an antitumor agent since the late 1960s. Because th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edfac7804ae0bc02518bb3b82e7f4219
https://doi.org/10.1021/tx800481j
https://doi.org/10.1021/tx800481j
Publikováno v:
Nucleic Acids Research
The differences in efficacy and molecular mechanisms of platinum based anti-cancer drugs cisplatin (CP) and oxaliplatin (OX) have been hypothesized to be in part due to the differential binding affinity of cellular and damage recognition proteins to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e4ebd232102c835a2e7edde847baa5
http://europepmc.org/articles/PMC2677858
http://europepmc.org/articles/PMC2677858
Autor:
Peng Gong, Nikolay V. Dokholyan, Shantanu Sharma, Brenda Temple, Stephen G. Chaney, Debadeep Bhattacharyya
Publikováno v:
Journal of Molecular Biology. 373:1123-1140
Mismatch repair proteins, DNA damage-recognition proteins and translesion DNA polymerases discriminate between Pt-GG adducts containing cis-diammine ligands (formed by cisplatin (CP) and carboplatin) and trans-RR-diaminocyclohexane ligands (formed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c681df013880a425a7d0be38968532
https://doi.org/10.1016/j.jmb.2007.07.079
https://doi.org/10.1016/j.jmb.2007.07.079
Autor:
Sharon Avkin, Nicholas E. Geacintov, Stephen G. Chaney, Leanne Toube, Zvi Livneh, Moshe Oren, Ziv Sevilya
Publikováno v:
Molecular Cell. 22(3):407-413
Regulation of mutation rates is critical for maintaining genome stability and controlling cancer risk. A special challenge to this regulation is the presence of multiple mutagenic DNA polymerases in mammals. These polymerases function in translesion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e85d67395732ae6f18f153b2bc55356
Autor:
Stephen G. Chaney, Ekaterina Bassett, Chikahide Masutani, Jody M. Havener, Alexandra Vaisman, Fumio Hanaoka
Publikováno v:
Biochemistry. 42:14197-14206
DNA polymerases beta and eta are among the few eukaryotic polymerases known to efficiently bypass cisplatin and oxaliplatin adducts in vitro. Our laboratory has previously established that both polymerases misincorporated dTTP with high frequency acr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff2618e34ac9a263bfbebfee3812f38
https://doi.org/10.1021/bi035359p
https://doi.org/10.1021/bi035359p
Autor:
Alexandra Vaisman, Ekaterina Bassett, Stephen G. Chaney, Chad M. McCall, Kristen A. Tropea, Chikahide Masutani, Fumio Hanaoka
Publikováno v:
DNA Repair. 1:1003-1016
DNA polymerases beta (pol beta ) and eta (pol eta ) are the only two eukaryotic polymerases known to efficiently bypass cisplatin and oxaliplatin adducts in vitro. Frameshift errors are an important aspect of mutagenesis. We have compared the types o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d98e48ab858415b8a8a6df3e3ce3e165
https://doi.org/10.1016/s1568-7864(02)00150-7
https://doi.org/10.1016/s1568-7864(02)00150-7
Autor:
Eric Raymond, Alex V. Trevino, Alexandra Vaisman, Stephen G. Chaney, Sandrine Faivre, Paul E. Juniewicz, Maryanne C. Herzig, William G. Chapman, Jan M. Woynarowski, Brenda Arnett, Maria Varchenko
Publikováno v:
Molecular Pharmacology. 58:920-927
Damage to cellular DNA is believed to determine the antiproliferative properties of platinum (Pt) drugs. This study characterized DNA damage by oxaliplatin, a diaminocyclohexane Pt drug with clinical antitumor activity. Compared with cisplatin, oxali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26dfc54ed023dbd110e5e16ae117a96f
https://doi.org/10.1124/mol.58.5.920
https://doi.org/10.1124/mol.58.5.920
Autor:
John J. Turchi, Susan E. Lim, Steve M. Patrick, Stephen G. Chaney, William C. Copeland, Alexandra Vaisman, David C. Hinkle
Publikováno v:
Biochemistry. 38:11026-11039
Translesion synthesis past Pt-DNA adducts can affect both the cytotoxicity and mutagenicity of the platinum adducts. We have shown previously that the extent of replicative bypass in vivo is influenced by the carrier ligand of platinum adducts. The s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c999877d36f5717079cae3f08636bb45
https://doi.org/10.1021/bi9909187
https://doi.org/10.1021/bi9909187
Publikováno v:
Cancer Chemotherapy and Pharmacology. 44:19-28
Purpose: Traditionally ultrafilterable Pt has been used to estimate the body exposure to platinum drugs. However, previous studies have shown that ultrafilterable Pt consists of both cytotoxic and inert biotransformation products of platinum drugs. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a858842383b9cb1f3bf6884a626290
https://doi.org/10.1007/s002800050940
https://doi.org/10.1007/s002800050940