Zobrazeno 1 - 10
of 20
pro vyhledávání: '"STAT3 Transcription Factor/metabolism"'
Autor:
Tadashi Matsuda, Kenji Oritani
Publikováno v:
Biological & pharmaceutical bulletin. 44(12):1810-1818
The signal-transducing adaptor protein (STAP) family, including STAP-1 and STAP-2, contributes to a variety of intracellular signaling pathways. The proteins in this family contain typical structures for adaptor proteins, such as Pleckstrin homology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50783c353cfecf8a916e4c56a63b71e8
http://hdl.handle.net/2115/87612
http://hdl.handle.net/2115/87612
Autor:
Deben, Debbie S, Creemers, Rob H, van Adrichem, Arjan J, Drent, Roosmarie, Merry, Audrey H H, Leers, Mathie P G, van Bodegraven, Adriaan A, Wong, Dennis R
Publikováno v:
Deben, D S, Creemers, R H, van Adrichem, A J, Drent, R, Merry, A H H, Leers, M P G, van Bodegraven, A A & Wong, D R 2022, ' A report on the potential of Rac1/pSTAT3 protein levels in T lymphocytes to assess the pharmacodynamic effect of thiopurine therapy in Inflammatory Bowel Disease patients ', Scientific Reports, vol. 12, no. 1, 15806 . https://doi.org/10.1038/s41598-022-20197-5
Scientific Reports, 12(1):15806. Nature Publishing Group
Scientific Reports, 12(1):15806. Nature Publishing Group
The thiopurine derivatives azathioprine (AZA), mercaptopurine (MP) and tioguanine (TG) remain standard treatment of inflammatory bowel disease (IBD). The immune suppressive effect of thiopurines is primarily based on blocking the Ras-related C3 botul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efbc2f106cd927332072a5f143dea7d9
https://doi.org/10.1038/s41598-022-20197-5
https://doi.org/10.1038/s41598-022-20197-5
Autor:
Izzettin Hatip-Al-Khatib, Funda F. Bölükbaşı Hatip, Junichi Matsumoto, Fuyuko Takata, Takashi Machida, Yasufumi Kataoka, Shinya Dohgu, Atsushi Yamauchi
Publikováno v:
Brain Research. 1692:34-44
Interleukin (IL)-6 is an important mediator of neurovascular dysfunction, neurodegeneration and/or neuroinflammation. We previously reported that brain pericytes released higher levels of IL-6 than did glial cells (astrocytes and microglia) in respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706aba2f546c7b20734ef8cf336638f0
https://doi.org/10.1016/j.brainres.2018.04.023
https://doi.org/10.1016/j.brainres.2018.04.023
Autor:
Yannick, Degboé, Benjamin, Rauwel, Michel, Baron, Jean-Frédéric, Boyer, Adeline, Ruyssen-Witrand, Arnaud, Constantin, Jean-Luc, Davignon
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, 2019, 10, 14 p. ⟨10.3389/fimmu.2019.00003⟩
Frontiers in Immunology, 2019, 10, 14 p. ⟨10.3389/fimmu.2019.00003⟩
International audience; Macrophages contribute to the pathogenesis of rheumatoid arthritis (RA). They can display different states of activation or "polarization," notably the so-called inflammatory "M1" and the various alternative "M2" polarizations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::255eea046ade31aac56a2cce2a50451f
http://europepmc.org/articles/PMC6345709
http://europepmc.org/articles/PMC6345709
Autor:
Warren J. Leonard, Nima Rezaei, Kathryn Payne, Isabelle Meyts, Laurent Abel, Cindy S. Ma, Marianne Leruez-Ville, Janet Chou, Alain Hovnanian, Jian-Xin Lin, Simon J. Pelham, Danielle T. Avery, Matthieu Bouaziz, Bethany Pillay, Tanwir Habib, Anne Puel, Sevgi Keles, Juan Li, Isabelle Pellier, Jamel El-Benna, Bernhard Fleckenstein, Ahmet Ozen, Vivien Béziat, Ingrid Müller-Fleckenstein, Damien Chaussabel, Samaneh Zoghi, Yi Wang, Paul Gray, Matthias Titeux, Yoann Zerbib, Talal A. Chatila, Marie-Alexandra Alyanakian, Capucine Picard, Orli Wargon, Ayper Somer, Marie-Olivia Chandesris, Thibaut Leclercq, Ibtihal Benhsaien, Aziz Belkadi, Jean-Laurent Casanova, Romain Lévy, Peng Li, Geetha Rao, Ai Ing Lim, James P. Di Santo, Nico Marr, Sylvie Fraitag, Frédégonde About, Elissa K. Deenick, Bertrand Boisson, Jacinta Bustamante, Mélanie Migaud, Bodo Grimbacher, Aziz Bousfiha, Fatima Ailal, Safa Baris, Antoine Guérin, Stuart G. Tangye, Romain Guery, Ning Du, Vimel Rattina
Publikováno v:
Science Immunology
Science Immunology, American Association for the Advancement of Science, 2018, 3 (24), pp.eaat4956. ⟨10.1126/sciimmunol.aat4956⟩
Science Immunology, 2018, 3 (24), pp.eaat4956. ⟨10.1126/sciimmunol.aat4956⟩
Science Immunology, American Association for the Advancement of Science, 2018, 3 (24), pp.eaat4956. ⟨10.1126/sciimmunol.aat4956⟩
Science Immunology, 2018, 3 (24), pp.eaat4956. ⟨10.1126/sciimmunol.aat4956⟩
Comment in :Who regulates whom: ZNF341 is an additional player in the STAT3/TH17 song. [Sci Immunol. 2018]; International audience; Heterozygosity for human signal transducer and activator of transcription 3 (STAT3) dominant-negative (DN) mutations u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a014e03bf19bbdfb4eb205a53e190a3a
https://doi.org/10.1126/sciimmunol.aat4956
https://doi.org/10.1126/sciimmunol.aat4956
Autor:
Lloyd-Lewis, Bethan, Krueger, Caroline C, Sargeant, Timothy J, D'Angelo, Michael E, Deery, Michael J, Feret, Renata, Howard, Julie A, Lilley, Kathryn S, Watson, Christine J
Publikováno v:
Lloyd-Lewis, B, Krueger, C C, Sargeant, T J, D'Angelo, M E, Deery, M J, Feret, R, Howard, J A, Lilley, K S & Watson, C J 2018, ' Stat3-mediated alterations in lysosomal membrane protein composition ', Journal of Biological Chemistry, vol. 293, no. 12, pp. 4244-4261 . https://doi.org/10.1074/jbc.RA118.001777
Lysosome function is essential in cellular homeostasis. In addition to its recycling role, the lysosome has recently been recognized as a cellular signaling hub. We have shown in mammary epithelial cells, both in vivo and in vitro, that signal transd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::068f05195a24e26484b273a5f17e844e
Autor:
Flavio Faletra, Gabriele Stocco, Evelyn Hartmann, Chantal Brouzes, Flavia Guillem, Fabrice Porcheray, Florence Uettwiller, Carolina Uggenti, Diego Vozzi, Marion Rabant, Capucine Picard, Nicolas Cagnard, Elisa Piscianz, Olivier Hermine, Andrea Taddio, Sophie Candon, Gunther Hartmann, Leo A. H. Zeef, Pierre Quartier, Marie Alexandra Alyanakian, Brigitte Bader-Meunier, Benoit Beitz, Gillian I. Rice, Muriel Girard, Monique Fabre, Alberto Tommasini, Dominique Lasne, Marine Depp, Nathalie Boddaert, Mathieu P Rodero, Stefano Volpi, Marco Gattorno, Yanick J. Crow, Eva Bartok, Michael Dussiot, Michel Polak, Tiffany Pascreau, Roberta Caorsi, Erika Della Mina, Naoki Kitabayashi, Annalisa Marcuzzi, Vincent Bondet, Paolo Picco, Luis Seabra, Jacques Beltrand, Erica Valencic, Marie-Louise Frémond, Bénédicte Neven, Frédéric Rieux-Laucat, Darragh Duffy, Alessandra Tesser, Patrick Nitschke, Anna Monica Bianco, Marina Charbit, Annie Harroche, Serena Pastore, Winfried Barchet
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2017, 8 (1), pp.2176. ⟨10.1038/s41467-017-01932-3⟩
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications, Nature Publishing Group, 2017, 8 (1), ⟨10.1038/S41467-017-01932-3⟩
Rodero, M P, Tesser, A, Bartok, E, Rice, G I, Della Mina, E, Depp, M, Beitz, B, Bondet, V, Cagnard, N, Duffy, D, Dussiot, M, Frémond, M, Gattorno, M, Guillem, F, Kitabayashi, N, Porcheray, F, Rieux-laucat, F, Seabra, L, Uggenti, C, Volpi, S, Zeef, L A H, Alyanakian, M, Beltrand, J, Bianco, A M, Boddaert, N, Brouzes, C, Candon, S, Caorsi, R, Charbit, M, Fabre, M, Faletra, F, Girard, M, Harroche, A, Hartmann, E, Lasne, D, Marcuzzi, A, Neven, B, Nitschke, P, Pascreau, T, Pastore, S, Picard, C, Picco, P, Piscianz, E, Polak, M, Quartier, P, Rabant, M, Stocco, G, Taddio, A, Uettwiller, F, Valencic, E, Vozzi, D, Hartmann, G, Barchet, W, Hermine, O, Bader-meunier, B, Tommasini, A & Crow, Y J 2017, ' Type I interferon-mediated autoinflammation due to DNase II deficiency ', Nature Communications, vol. 8, no. 1, 2176 . https://doi.org/10.1038/s41467-017-01932-3
Nature Communications, 2017, 8 (1), pp.2176. ⟨10.1038/s41467-017-01932-3⟩
Rodero, M P, Tesser, A, Bartok, E, Rice, G, Della Mina, E, Depp, M, Beitz, B, Bondet, V, Cagnard, N, Duffy, D, Dussiot, M, Fremond, M-L, Gattorno, M, Guillem, F, Kitabayashi, N, Porcheray, F, Rieux-Laucat, F, Seabra, L, Uggenti, C, Volpi, S, Zeef, L, Alyanakian, M-A, Beltrand, J, Bianco, A M, Boddaert, N, Brouzes, C, Candon, S, Caorsi, R, Charbit, M, Fabre, M, Faletra, F, Girard, M, Harroche, A, Hartmann, E, Lasne, D, Marcuzzi, A, Neven, B, Nitschke, P, Pascreau, T, Pastore, S, Picard, C, Picco, P P, Piscianz, E, Polak, M, Quartier, P, Rabant, M, Stocco, G, Taddio, A, Uettwiller, F, Valencic, E, Vozzi, D, Hartmann, G, Barchet, W, Hermine, O, Bader-Meunier, B, Tommasini, A & Crow, Y 2017, ' Type I interferon mediated autoinflammation due to DNase II deficiency ', Nature Communications, vol. 8, 2176 . https://doi.org/10.1038/s41467-017-01932-3
Nature Communications, Nature Publishing Group, 2017, 8 (1), pp.2176. ⟨10.1038/s41467-017-01932-3⟩
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications, Nature Publishing Group, 2017, 8 (1), ⟨10.1038/S41467-017-01932-3⟩
Rodero, M P, Tesser, A, Bartok, E, Rice, G I, Della Mina, E, Depp, M, Beitz, B, Bondet, V, Cagnard, N, Duffy, D, Dussiot, M, Frémond, M, Gattorno, M, Guillem, F, Kitabayashi, N, Porcheray, F, Rieux-laucat, F, Seabra, L, Uggenti, C, Volpi, S, Zeef, L A H, Alyanakian, M, Beltrand, J, Bianco, A M, Boddaert, N, Brouzes, C, Candon, S, Caorsi, R, Charbit, M, Fabre, M, Faletra, F, Girard, M, Harroche, A, Hartmann, E, Lasne, D, Marcuzzi, A, Neven, B, Nitschke, P, Pascreau, T, Pastore, S, Picard, C, Picco, P, Piscianz, E, Polak, M, Quartier, P, Rabant, M, Stocco, G, Taddio, A, Uettwiller, F, Valencic, E, Vozzi, D, Hartmann, G, Barchet, W, Hermine, O, Bader-meunier, B, Tommasini, A & Crow, Y J 2017, ' Type I interferon-mediated autoinflammation due to DNase II deficiency ', Nature Communications, vol. 8, no. 1, 2176 . https://doi.org/10.1038/s41467-017-01932-3
Nature Communications, 2017, 8 (1), pp.2176. ⟨10.1038/s41467-017-01932-3⟩
Rodero, M P, Tesser, A, Bartok, E, Rice, G, Della Mina, E, Depp, M, Beitz, B, Bondet, V, Cagnard, N, Duffy, D, Dussiot, M, Fremond, M-L, Gattorno, M, Guillem, F, Kitabayashi, N, Porcheray, F, Rieux-Laucat, F, Seabra, L, Uggenti, C, Volpi, S, Zeef, L, Alyanakian, M-A, Beltrand, J, Bianco, A M, Boddaert, N, Brouzes, C, Candon, S, Caorsi, R, Charbit, M, Fabre, M, Faletra, F, Girard, M, Harroche, A, Hartmann, E, Lasne, D, Marcuzzi, A, Neven, B, Nitschke, P, Pascreau, T, Pastore, S, Picard, C, Picco, P P, Piscianz, E, Polak, M, Quartier, P, Rabant, M, Stocco, G, Taddio, A, Uettwiller, F, Valencic, E, Vozzi, D, Hartmann, G, Barchet, W, Hermine, O, Bader-Meunier, B, Tommasini, A & Crow, Y 2017, ' Type I interferon mediated autoinflammation due to DNase II deficiency ', Nature Communications, vol. 8, 2176 . https://doi.org/10.1038/s41467-017-01932-3
Microbial nucleic acid recognition serves as the major stimulus to an antiviral response, implying a requirement to limit the misrepresentation of self nucleic acids as non-self and the induction of autoinflammation. By systematic screening using a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7996f15867050dcd49eb11d20f8f073
https://hal-pasteur.archives-ouvertes.fr/pasteur-01768950/document
https://hal-pasteur.archives-ouvertes.fr/pasteur-01768950/document
Autor:
L.M. Blanco-Colio, Carlos Tarin, Jes S. Lindhot, J.L. Martin-Ventura, Monica Maria Torres-Fonseca, Raquel Roldan-Montero, Carlos-Ernesto Fernandez-García, Diego Martinez-Lopez, Natalia López-Andrés, Melina Vega de Ceniga, Jesús Egido
Publikováno v:
Fernandez-García, C-E, Tarin, C, Roldan-Montero, R, Martinez-Lopez, D, Torres-Fonseca, M, Lindhot, J S, Vega de Ceniga, M, Egido, J, Lopez de Andres, N, Blanco-Colio, L-M & Martín-Ventura, J-L 2017, ' Increased galectin-3 levels are associated with abdominal aortic aneurysm progression and inhibition of galectin-3 decreases elastase-induced AAA development ', Clinical Science, vol. 131, no. 22, pp. 2707–2719 . https://doi.org/10.1042/CS20171142
Abdominal aortic aneurysm (AAA) evolution is unpredictable and no specific treatment exists for AAA, except surgery to prevent aortic rupture. Galectin-3 has been previously associated with CVD, but its potential role in AAA has not been addressed. G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bce803785d3e1448f63d6ea6f8bc4409
https://pubmed.ncbi.nlm.nih.gov/28982723
https://pubmed.ncbi.nlm.nih.gov/28982723
Autor:
Hartmut Goldschmidt, Verena Wagner, Anja Seckinger, Ludmila Weiz, Iris Breitkreutz, Thiery Rème, Dirk Hose, Anthony D. Ho, Bernard Klein, Klaus Podar, Tobias Meißner, Alwin Krämer, Marc S. Raab
Publikováno v:
Oncotarget
// Verena Wagner 1,* , Dirk Hose 2,3,* , Anja Seckinger 2 , Ludmila Weiz 1 , Tobias Meisner 2 , Thiery Reme 4 , Iris Breitkreutz 1,3 , Klaus Podar 3 , Anthony D. Ho 2 , Hartmut Goldschmidt 2,3 , Alwin Kramer 5 , Bernard Klein 4,6 and Marc S. Raab 1,2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b09ec03c7bfd5665033d40dfbbe03fd
https://doi.org/10.18632/oncotarget.2529
https://doi.org/10.18632/oncotarget.2529
Autor:
Wu Chuan, Pot Caroline, Apetoh Lionel, Thalhamer Theresa, Zhu Bing, Murugaiyan Gopal, Xiao Sheng, Lee Youjin, Rangachari Manu, Yosef Nir, Kuchroo Vijay K.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences, Vol. 110, No 19 (2013) pp. 7802-7
Proceedings of the National Academy of Sciences, Vol. 110, No 19 (2013) pp. 7802-7
IL-27–induced type 1 regulatory T (Tr1) cells suppress autoimmunity by producing IL-10. Signal transducer and activator of transcription (STAT) 1 and STAT3 have been described as key transcription factors that promote IL-10 secretion from Tr1 cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e296b1ea9015a1ee41a7963aa689f8ee
https://doi.org/10.1073/pnas.1211776110
https://doi.org/10.1073/pnas.1211776110