Výsledky vyhledávání - "STAT3 Decoy Oligonucleotide"

STAT3 decoy oligonucleotide-carrying microbubbles with pulsed ultrasound for enhanced therapeutic effect in head and neck tumors

Autor: Flordeliza S. Villanueva, Xucai Chen, Jennifer R. Grandis, Bin Qin, Daniel Johnson, Thiruganesh Ramasamy

Publikováno v: PloS one, vol 15, iss 11
PLoS ONE
PLoS ONE, Vol 15, Iss 11, p e0242264 (2020)

Signal transducer and activator of transcription-3 (STAT3) is an oncogenic transcription factor implicated in carcinogenesis, tumor progression, and drug resistance in head and neck squamous cell carcinoma (HNSCC). A decoy oligonucleotide targeting S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b8951461afb4cd1d3bd088c55b666b
https://doi.org/10.1371/journal.pone.0242264

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4373 Defining the role of non-canonical PIK3CA mutations in head and neck squamous cell carcinoma

Autor: Michelle J. Lee, Gordon B. Mills, Jennifer R. Grandis, Nan Jin, Daniel Johnson, Patrick Kwok-shing, Janice Cho

Publikováno v: Journal of Clinical and Translational Science. 4:5-5

OBJECTIVES/GOALS: To characterize the oncogenic potential of HNSCC cell lines harboring 17 non-canonical PIK3CA mutations. METHODS/STUDY POPULATION: Non-canonical PIK3CA mutant constructs generated via site-directed mutagenesis are subcloned into dox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01a3ea96f9e83b66c0083d80e945a15e
https://doi.org/10.1017/cts.2020.60

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Inorganic Kernel-Reconstituted Lipoprotein Biomimetic Nanovehicles Enable Efficient Targeting 'Trojan Horse' Delivery of STAT3-Decoy Oligonucleotide for Overcoming TRAIL Resistance

Autor: Shan Gao, Liyuan Ke, Yuai Li, Anqi Lu, Dongjuan Yang, Yan Fang, Yao Chen, Hongshu Bi, Jianxiu Xue, Kai Shi

Publikováno v: Theranostics

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively induce apoptosis in a variety of tumor cells, but not most normal cells. Nevertheless, its therapeutic potential is limited due to the frequent occurrence of resistance i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a825685e7656a6cf7e78ef965538d9
https://pubmed.ncbi.nlm.nih.gov/29158840

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Lack of toxicity of a STAT3 decoy oligonucleotide

Autor: James O. Peggins, Christa Zwayer, Michael J. Ryan, Jerry D. Johnson, Joseph E. Tomaszewski, Daniel Johnson, Jennifer R. Grandis, Patricia J. Tosca, Patricia C. Giclas, Robert L. Ferris, William E. Gooding, Sufi M. Thomas, Timothy P McMurray, Malabika Sen, Changyou Li, Katherine A. B. Knostman, Michael S. Leibowitz

Publikováno v: Cancer Chemotherapy and Pharmacology. 63:983-995

STAT3 overexpression has been detected in several cancers including head and neck squamous cell carcinoma (HNSCC). Previous studies using intratumoral administration of a STAT3 decoy oligonucleotide that abrogates STAT3-mediated gene transcription in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e64fdf96827c7cacf2a3d64ca775c9
https://doi.org/10.1007/s00280-008-0823-6

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Recent advances in head and neck squamous cell carcinoma--a review

Autor: Mahnaz Sadeghi, Mohammad Asgharzadeh, Masoumeh Khalili, Safar Farajnia, Yaghoub Yazdani, Yaghoub Safdari

Publikováno v: Clinical biochemistry. 47(13-14)

The current review presents the results of the most recent studies performed on different aspects of human head and neck squamous cell carcinoma, including radiosensitivity induction, efficiency improvement of monoclonal antibodies using low-intensit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9bada4aa1e9db1b24de41512d42d00
https://pubmed.ncbi.nlm.nih.gov/24912050

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First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy

Publikováno v: Cancer discovery, vol 2, iss 8

Despite evidence implicating transcription factors, including STAT3, in oncogenesis, these proteins have been regarded as “undruggable.” We developed a decoy targeting STAT3 and conducted a phase 0 trial. Expression levels of STAT3 target genes w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e8d4e79ef9a43518ef0fd3a383ed10
https://escholarship.org/uc/item/68s0x1b7

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Bortezomib up-regulates activated signal transducer and activator of transcription-3 and synergizes with inhibitors of signal transducer and activator of transcription-3 to promote head and neck squamous cell carcinoma cell death

Autor: David Man, Rebecca J. Leeman-Neill, Yan Zang, Changyou Li, Daniel Johnson, Jennifer R. Grandis, Malabika Sen

Publikováno v: Molecular cancer therapeutics. 8(8)

Head and neck squamous cell carcinomas (HNSCC) are commonly resistant to conventional chemotherapy drugs and exhibit overexpression of signal transducer and activator of transcription 3 (STAT3). STAT3 promotes both the proliferation and survival of H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96dc6afa335ab72d3cbbc2248f5a8db
https://pubmed.ncbi.nlm.nih.gov/19638453

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STAT3 Oligonucleotide Inhibits Tumor Angiogenesis in Preclinical Models of Squamous Cell Carcinoma

Autor: Seungwon Kim, Jeffrey N. Myers, Jonah D. Klein, Daisuke Sano, Malabika Sen, Jennifer R. Grandis

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e81819 (2014)
PLoS ONE

Purpose Signal transducer and activator of transcription 3 (STAT3) has shown to play a critical role in head and neck squamous cell carcinoma (HNSCC) and we have recently completed clinical trials of STAT3 decoy oligonucleotide in patients with recur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1b1bdbcdea0b8e97272b692132b62d1
https://doi.org/10.1371/journal.pone.0081819

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Critical analysis of the potential for targeting STAT3 in human malignancy

Autor: Jennifer R. Grandis, Noah D. Peyser

Publikováno v: OncoTargets and therapy

The signal transducer and activator of transcription (STAT) family of proteins was originally discovered in the context of normal cell biology where they function to transduce intracellular and extracellular signals to the nucleus, ultimately leading

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935cf9f62e7a749a7009aa62719dcb18
https://doi.org/10.2147/ott.s47903

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A STAT3-decoy oligonucleotide induces cell death in a human colorectal carcinoma cell line by blocking nuclear transfer of STAT3 and STAT3-bound NF-κB

Autor: Denis Lesage, Pierre Olivier Schischmanoff, Nadine Varin-Blank, Isabelle Dusanter-Fourt, Valeri Metelev, Inès Souissi, An Cao, Fanny Baran-Marszak, Laurent Ah-Koon, Stéphanie Le Coquil, Imen Najjar, Remi Fagard, Claudine Roger

Publikováno v: BMC Cell Biology
BMC Cell Biology, Vol 12, Iss 1, p 14 (2011)
BMC Cell Biology, BioMed Central, 2011, 12 (1), pp.14. 〈10.1186/1471-2121-12-14〉
BMC Cell Biology, BioMed Central, 2011, 12 (1), pp.14. ⟨10.1186/1471-2121-12-14⟩
BMC Cell Biology, 2011, 12 (1), pp.14. ⟨10.1186/1471-2121-12-14⟩

Background The transcription factor STAT3 (signal transducer and activator of transcription 3) is frequently activated in tumor cells. Activated STAT3 forms homodimers, or heterodimers with other TFs such as NF-κB, which becomes activated. Cytoplasm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5bdf102f48c8c7043bef930bf549c54
http://europepmc.org/articles/PMC3082224

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