Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1

Autor: Indu R. Chandrashekaran, Alex N. Bullock, Raymond S. Norton, Andrew I. Webb, Jeffrey J. Babon, Tatiana B. Kolesnik, Sandra E. Nicholson, James M. Murphy, Edmond M. Linossi, Nicos A. Nicola, Lukasz Kedzierski, Tracy A. Willson

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 8, p e70536 (2013)

Suppressor of Cytokine Signaling (SOCS)5 is thought to act as a tumour suppressor through negative regulation of JAK/STAT and epidermal growth factor (EGF) signaling. However, the mechanism/s by which SOCS5 acts on these two distinct pathways is uncl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5e9d418fc48669f9b7d2dd0d460cf1
https://ora.ox.ac.uk/objects/uuid:3add4550-fe13-49bb-93e9-0b74b4214f08

FRA2 Is a STAT5 Target Gene Regulated by IL-2 in Human CD4 T Cells

Autor: Aradhana Rani, Roseanna Greenlaw, Manohursingh Runglall, Stipo Jurcevic, Susan John

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 2, p e90370 (2014)

Signal transducers and activators of transcription 5(STAT5) are cytokine induced signaling proteins, which regulate key immunological processes, such as tolerance induction, maintenance of homeostasis, and CD4 T-effector cell differentiation. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e33803341ccb9e6a7b1c3d6b6c9dc736
http://europepmc.org/articles/PMC3938719

Identification of STAT5A and STAT5B Target Genes in Human T Cells

Autor: Kari C. Nadeau, Jennifer A. Jenks, Rosa Bacchetta, Dorrelyn Patacsil Martin, Arunima Kohli, Takahiro Kanai, Michael Snyder, Scott Seki, Trupti Kawli

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 1, p e86790 (2014)

Signal transducer and activator of transcription (STAT) comprises a family of universal transcription factors that help cells sense and respond to environmental signals. STAT5 refers to two highly related proteins, STAT5A and STAT5B, with critical fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::031a8907e329a2e2c689a157b80e45b6
http://europepmc.org/articles/PMC3907443

Btk Regulates Macrophage Polarization in Response to Lipopolysaccharide

Autor: Claire Wynne, James A. Johnston, Jennifer C. Byrne, Siobhán Smith, Adrien Kissenpfennig, Padraic G. Fallon, Emily Hams, Caroline A. Jefferies, Joan Ní Gabhann, Kiva Brennan, Shaun Spence

Publikováno v: PLoS ONE
Articles
PLoS ONE, Vol 9, Iss 1, p e85834 (2014)
Ní Gabhann, J, Hams, E, Smith, S, Wynne, C, Byrne, J C, Brennan, K, Spence, S, Kissenpfennig, A, Johnston, J A, Fallon, P G & Jefferies, C A 2014, ' Btk regulates macrophage polarization in response to lipopolysaccharide ', PloS one, vol. 9, no. 1, e85834 . https://doi.org/10.1371/journal.pone.0085834

Bacterial Lipopolysaccharide (LPS) is a strong inducer of inflammation and does so by inducing polarization of macrophages to the classic inflammatory M1 population. Given the role of Btk as a critical signal transducer downstream of TLR4, we investi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d37704e4527d224763496e5320febea
http://europepmc.org/articles/PMC3897530

The synthetic α-bromo-2',3,4,4'-tetramethoxychalcone (α-Br-TMC) inhibits the JAK/STAT signaling pathway

Autor: Sophia, Pinz, Samy, Unser, Susanne, Brueggemann, Elisabeth, Besl, Nafisah, Al-Rifai, Hermina, Petkes, Sabine, Amslinger, Anne, Rascle

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e90275 (2014)
PLoS ONE

Signal transducer and activator of transcription STAT5 and its upstream activating kinase JAK2 are essential mediators of cytokine signaling. Their activity is normally tightly regulated and transient. However, constitutive activation of STAT5 is fou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f5691a3c33a9bfa10b0d944e489c159a
http://europepmc.org/articles/PMC3940872?pdf=render