Zobrazeno 1 - 10
of 6 584
pro vyhledávání: '"STAT signaling"'
Publikováno v:
Türk Biyokimya Dergisi, Vol 49, Iss 5, Pp 637-646 (2024)
Cholangiocarcinoma (CCA) is a highly heterogeneous biliary malignant tumor. Studies have demonstrated that JAK/STAT signaling is activated in many types of cancer. In addition, JAK/STAT is activated downstream of AXL, and the AXL receptor is activate
Externí odkaz:
https://doaj.org/article/ee995ba0618a492089b90f25789f5983
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background and PurposeThe damage or apoptosis of retinal ganglion cells (RGCs) is one of the leading causes of various blinding eye diseases, such as glaucoma, diabetic retinopathy, optic neuritis, and ischemic optic neuropathy. Oxidative stress is i
Externí odkaz:
https://doaj.org/article/2a673f3dfec746a2a424e20def7e90fc
Autor:
Shachee Swaraj, Shashank Tripathi
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT Interferons (IFNs) are multifaceted proteins that play pivotal roles in orchestrating robust antiviral immune responses and modulating the intricate landscape of host immunity. The major signaling pathway activated by IFNs is the JAK/STAT (J
Externí odkaz:
https://doaj.org/article/cb413c68edb34cd3933640e12a4caf43
Publikováno v:
Allergy, Asthma & Clinical Immunology, Vol 20, Iss 1, Pp 1-10 (2024)
Abstract Objective The aim of this study was to investigate the role and mechanisms of miR-155 in chronic spontaneous urticaria (CSU). Methods The expression level of miR-155 in the skin tissues of patients with CSU and experimental rats were detecte
Externí odkaz:
https://doaj.org/article/08c546383dd44caabd6ec83517cce152
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-16 (2024)
Abstract Background Diabetic nephropathy (DN) is a life-threatening renal disease and needs urgent therapies. Wogonin is renoprotective in DN. This study aimed to explore the mechanism of how wogonin regulated high glucose (HG)-induced renal cell inj
Externí odkaz:
https://doaj.org/article/57a359c3a72c4acaae18284da3c85cb4
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background The metabolically demanding nature of immune response requires nutrients to be preferentially directed towards the immune system at the expense of peripheral tissues. We study the mechanisms by which this metabolic reprograming oc
Externí odkaz:
https://doaj.org/article/60a7247936f24916bf764005e37699d0
Autor:
Pascal Forrer, Darya Palianina, Claudia Stühler, Matthias Kreuzaler, Julien Roux, Jiagui Li, Christoph Schmutz, David Burckhardt, Fabian Franzeck, Daniela Finke, Alexander Schmidt, Dirk Bumann, Nina Khanna
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionGram-negative bacillary bacteremia poses a significant threat, ranking among the most severe infectious diseases capable of triggering life-threatening sepsis. Despite the unambiguous involvement of neutrophils in this potentially fatal d
Externí odkaz:
https://doaj.org/article/f248e605f0424033abfa4c81039890fc
Autor:
Shima Hadifar, Nasrin Masoudzadeh, Hossein Heydari, Vahid Mashayekhi Goyonlo, Mohammadali Kerachian, Maryam Daneshpazhooh, Ali Sadeghnia, Nasim Tootoonchi, Reza Erfanian Salim, Sima Rafati, Ali M. Harandi
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundThe JAK-STAT signaling pathway is a central cascade of signal transduction for the myriad of cytokines in which dysregulation has been implicated in progression of inflammatory and infectious diseases. However, the involvement of this pathw
Externí odkaz:
https://doaj.org/article/48566023b44448ebb7eacf9551d6b4dd
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IBD (inflammatory bowel disease) is a chronic inflammatory disease of the gastrointestinal tract with increasing incidence worldwide. Multiple factors, such as genetic background, environmental and luminal factors, and mucosal immune dysregulation, h
Externí odkaz:
https://doaj.org/article/59dd5f00eaa940bf8f8b6d79914d7ed3
Autor:
Wenshuang Wang, Yanhong Ji, Zhexu Dong, Zheran Liu, Shuang Chen, Lei Dai, Xiaolan Su, Qingyuan Jiang, Hongxin Deng
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-24 (2024)
Abstract Background Neural Tube Defects (NTDs) are congenital malformations of the central nervous system resulting from the incomplete closure of the neural tube during early embryonic development. Neuroinflammation refers to the inflammatory respon
Externí odkaz:
https://doaj.org/article/c9fbe556209f490d9b8874959c145d19