Výsledky vyhledávání - "STAT, signal transducers and activators of transcription"

Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management

Autor: Hai-Yong Chen, Yibin Feng, Cheng Zhang, Ning Wang, Sha Li, Guoyi Tang

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)

Diabetic nephropathy (DN) has been recognized as a severe complication of diabetes mellitus and a dominant pathogeny of end-stage kidney disease, which causes serious health problems and great financial burden to human society worldwide. Conventional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d8ab4193adc39b242fa3c089b4f517
https://doi.org/10.1016/j.apsb.2020.12.020

Zobrazit plný text záznamu

Control of Intestinal Epithelial Permeability by Lysophosphatidic Acid Receptor 5

Autor: Mo Wang, C. Chris Yun, Yiran Han, Lei Dong, Peijian He

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 1073-1092 (2021)

Background & Aims Epithelial cells form a monolayer at mucosal surface that functions as a highly selective barrier. Lysophosphatidic acid (LPA) is a bioactive lipid that elicits a broad range of biological effects via cognate G protein-coupled recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76070d2010df41333ad81cb10e8a8f40
http://europepmc.org/articles/PMC8350072

Zobrazit plný text záznamu

Mettl14-Mediated m6A Modification Facilitates Liver Regeneration by Maintaining Endoplasmic Reticulum Homeostasis

Autor: Mingyang Shao, Qing Xu, Menglin Chen, Xiaoyue Cao, Chuan Li, Hong Bu, Yuwei Chen, Yuke Shu, Zhenru Wu, Gang Guo, Yuping Gong, Yongjie Zhou, Yujun Shi

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 633-651 (2021)

Background & Aims N6-methyladenosine (m6A), the most prevalent and dynamic posttranscriptional methylation modification of mammalian mRNA, is involved in various biological processes, but its role in liver regeneration has not been characterized. Met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07948b84c6263e6b798b7056d5735a81
https://doi.org/10.1016/j.jcmgh.2021.04.001

Zobrazit plný text záznamu

Oncosuppressive role of MicroRNA-205–3p in gastric cancer through inhibition of proliferation and induction of senescence

Autor: Naiqian Wang, Keyan Chen, Xiaoyu Ma, Chenlu Zhang

Publikováno v: Translational Oncology
Translational Oncology, Vol 14, Iss 11, Pp 101199-(2021)

Highlights • The molecular mechanism of miR-205-3p in inhibiting the proliferation and invasion of GC was elucidated in animal and cell experiments. • The molecular mechanism of miR-205-3p in induction of senescence by inhibiting CXCL11 and Akt p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33eafd2abe46d77dc285b815c1e96d4b
http://europepmc.org/articles/PMC8363882

Zobrazit plný text záznamu

Prediction and analysis of microRNAs involved in COVID-19 inflammatory processes associated with the NF-kB and JAK/STAT signaling pathways

Autor: Zeinab Amini-Farsani, Mahtab Yadollahi-Farsani, Samira Asgharzade, Fatemeh Forouzanfar, Mitra Yadollahi, Samaneh Arab

Publikováno v: International Immunopharmacology

COVID-19 is the cause of a pandemic associated with substantial morbidity and mortality. As yet, there is no available approved drug to eradicate the virus. In this review article, we present an alternative study area that may contribute to the devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8773adb656d31880c2095312d49df64
http://europepmc.org/articles/PMC8378592

Zobrazit plný text záznamu

Chemotherapy vs. Immunotherapy in combating nCOVID19: An update

Autor: Gargi Mukherjee, Suprabhat Mukherjee, Abhigyan Choudhury

Publikováno v: Human Immunology

The nCOVID-19 pandemic initiated its course of contagion from the city of Wuhan and now it has spread all over the globe. SARS-CoV-2 is the causative virus and the infection as well as its symptoms are distributed across the multi-organ perimeters. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab4dd5c897b315e07b36bdee608aa90
http://europepmc.org/articles/PMC8130497

Zobrazit plný text záznamu

A novel compound heterozygous leptin receptor mutation causes more severe obesity than in Lepr

Autor: Claudia Berger, Matthias Blüher, Janet Kelso, Nora Klöting, Henrike O. Heyne, Esther Guiu-Jurado, Tina Heiland, Peter Kovacs, Sebastian Dommel, Steffen Roßner, Michael Dannemann, Corinna Höfling, Jana Lorenz

Publikováno v: Journal of Lipid Research
J. Lipid Res. 62:100105 (2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100105-(2021)

The leptin receptor (Lepr) pathway is important for food intake regulation, energy expenditure and body weight. Mutations in leptin and the Lepr have been shown to cause early-onset severe obesity in mice and humans. In studies with C57BL/6NCrl mice,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27187f8e7883d9974250f02e58c65888
https://pubmed.ncbi.nlm.nih.gov/34390703

Zobrazit plný text záznamu

Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential therapeutic interventions

Autor: Bhaskar Saha, Sara Jafarzadeh, Abdollah Jafarzadeh, Prashant Chauhan, Maryam Nemati

Publikováno v: Life Sciences

The COVID-19-, SARS- and MERS-related coronaviruses share many genomic and structural similarities. However, the SARS-CoV-2 is less pathogenic than SARS-CoV and MERS-CoV. Despite some differences in the cytokine patterns, it seems that the cytokine s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7322b337aefb9daa41a6797333781382

Zobrazit plný text záznamu

Anti-malarial drug, artemisinin and its derivatives for the treatment of respiratory diseases

Autor: Daniel W.S. Tan, Fred W.S. Wong, Dorothy H.J. Cheong, Thai Tran

Publikováno v: Pharmacological Research

Graphical abstract Molecular targets modulated by artemisinins in respiratory diseases.
Artemisinins are sesquiterpene lactones with a peroxide moiety that are isolated from the herb Artemisia annua. It has been used for centuries for the treatm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::184b9b3d7b7767e97cb84ac3227c7da4

Zobrazit plný text záznamu

Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies

Autor: Xiao-Feng Xiong, Yang Sun, Xue Ping Chen, Zhendong Song, Ziyang Xu, Yang Ge, Meijing Wang

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 1, Pp 13-29 (2021)

Src homology containing protein tyrosine phosphatase 2 (SHP2) represents a noteworthy target for various diseases, serving as a well-known oncogenic phosphatase in cancers. As a result of the low cell permeability and poor bioavailability, the tradit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377d61b2602a59fd7130cd6ded70715c
https://pubmed.ncbi.nlm.nih.gov/33532178

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání