Editorial: JAK inhibition in autoimmune and inflammatory diseases

Autor: Jean-Baptiste Telliez, Massimo Gadina, Kamran Ghoreschi, Olli Silvennoinen, Francesca Romana Spinelli

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Externí odkaz: https://doaj.org/article/2d315910124d4ad8a4db33f8e630f4f6

A Call for Epidemiological Research on Myeloid-Derived Suppressor Cells in Ovarian Cancer: A Review of the Existing Immunological Evidence and Suggestions for Moving Forward

Autor: Ashley E. Stenzel, Scott I. Abrams, Kirsten B. Moysich

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Recently, there have been encouraging findings suggesting that myeloid-derived suppressor cells (MDSCs) may be a good target for studying immune suppression in ovarian cancer. MDSCs are an abundance of immature myeloid cells that have demonstrated th

Externí odkaz: https://doaj.org/article/4e39d420b2f849b3816072b361c03d81

STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implications

Autor: David A. Frank, Isidora Tošić

Publikováno v: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1167-1178 (2021)

The oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) is activated constitutively in a wide array of human cancers. It is an appealing molecular target for novel therapy as it directly regulates expression of g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95fc1e221705a2edcb47149735290583
http://europepmc.org/articles/PMC8569436

A Novel Microphysiological Colon Platform to Decipher Mechanisms Driving Human Intestinal Permeability

Autor: Rohit A. Panchakshari, Athanasia Apostolou, Cosmas Giallourakis, Galeb Abu-Ali, Antara Banerjee, Tengku Ibrahim Maulana, Raymond Luc, Gauri Kulkarni, Carolina Lucchesi, Jordan Kerns, Katia Karalis, Alexandra Dimitriou, Maria D. Paraskevopoulou, Magdalena Kasendra, Elias S. Manolakos, Lorna Ewart, Geraldine A. Hamilton, Bertram Bleck, Dimitris V. Manatakis

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1719-1741 (2021)

Background & Aims The limited availability of organoid systems that mimic the molecular signatures and architecture of human intestinal epithelium has been an impediment to allowing them to be harnessed for the development of therapeutics as well as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c73f86b030301637ffe301dbedd59d97
http://europepmc.org/articles/PMC8551844

A multifunctional cross-validation high-throughput screening protocol enabling the discovery of new SHP2 inhibitors

Autor: Hong-Min Liu, Ya-Hong Wu, Yihui Song, Min Zhao, Bin Yu

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 750-762 (2021)
Acta Pharmaceutica Sinica. B

The protein tyrosine phosphatase Src homology phosphotyrosyl phosphatase 2 (SHP2) is implicated in various cancers, and targeting SHP2 has become a promising therapeutic approach. We herein described a robust cross-validation high-throughput screenin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::114cd1e4de1acb4de79002f71ffaa0be
https://doi.org/10.1016/j.apsb.2020.10.021